Single and Multiple Selenium-Zinc-Iodine Deficiencies Affect Rat Thyroid Metabolism and Ultrastructure

Ruz, Manuel; Codoceo, Juana; Galgani, José E.; Muñoz, Lorena; Gras, N.; Muzzo, S; Leiva, Laura; Bosco, Cleofina

doi:10.1093/jn/129.1.174

Cited by 71 publications

(27 citation statements)

References 32 publications

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“…Selenium also plays an important role in the immune system and the metabolism of thyroid hormones. It is also crucial for reproduction (McKenzie et al, 1998;Ruz et al, 1999;Birringer et al, 2002).…”

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Effect of supplementation of various selenium forms and doses on selected parameters of ruminal fluid and blood in sheep

Panev¹,

Hauptmanová²,

Pavlata³

et al. 2013

Czech J. Anim. Sci.

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Effect of various doses and forms of selenium (organically bound vs. inorganic) on selected parameters of ruminal fluid and blood in sheep was evaluated. The trial was performed with 15 sheep divided into two groups. Animals from group A (n = 8) received a feeding mixture with selenomethionine, while sheep from group B (n = 7) were fed a mixture with sodium selenite. During the first 14 days, animals from both groups were fed a mixture with optimum dose of selenium (1 mg Se/kg dry matter). For another 28 days, all experimental animals received a Se-deficient mixture (0.1 mg Se/kg dry matter), whereas in the last 21 days of the experiment, animals were fed a high-Se diet (5.0 mg Se/kg dry matter). Throughout the trial, 4 samples of blood and ruminal fluid were taken from each animal. The samples of ruminal fluid were analyzed to determine the concentration of Se and identify other parameters of ruminal fermentations. Selenium levels were also determined in ruminal biomass. In blood, Se concentration, glutathione peroxidase (GSH-Px) activity, and other selected biochemical parameters were measured. The results of the present study demonstrate that the actual intake of both organic and inorganic Se is reflected in Se concentration in ruminal fluid and ruminal biomass and, similarly, in Se content and GSH-Px activity in blood. The form of supplemented selenium did not have a significant effect on ruminal fermentation parameters in dependence on different doses of Se contained in feeding rations (except for the negative effect of a sudden start of feeding high levels of organically bound Se on infusoria count, which was accompanied by the increase of GMT, LDH, and AST enzymes activity in ruminal fluid). The results also suggest possible negative interaction between the intake of organically bound selenium and the concentration of copper in blood of sheep.

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confidence: 99%

Effect of supplementation of various selenium forms and doses on selected parameters of ruminal fluid and blood in sheep

Panev¹,

Hauptmanová²,

Pavlata³

et al. 2013

Czech J. Anim. Sci.

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“…Zinc also may play important roles in thyroid metabolism. Thus, its low (Gupta et al, 1997;Ruz et al, 1999) or excessive (Dean et al, 1991) levels may cause numerous abnormalities. Therefore, it has been emphasised that excessive dietary zinc intake re-Acta Veterinaria Hungarica 50, 2002 sulted in disturbances in serum thyroid hormone levels in man (Miyamoto et al, 1991) and animals (Dean et al, 1991).…”

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Zinc supplementation decreases total thyroid hormone concentration in small ruminants

Keçeci

Keskin

2002

Acta Veterinaria Hungarica

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The effect of dietary zinc (Zn) supplementation on plasma Zn and serum thyroid hormones was evaluated in healthy male Merino lambs and Angora goats. A total of 12 lambs and 12 goats were divided into two equal groups as control and Zn groups in separate experiments. The lambs and goats of the control groups were fed basal rations alone. The Zn contents of these rations prepared for lambs and goats were 40 mg/kg and 35 mg/kg in dry matter (DM), respectively. Both species of animals in the Zn groups were fed a basal ration supplemented with zinc sulphate adjusted to 250 mg Zn/kg diet in DM. The feeding trial lasted for 12 weeks in lambs and 8 weeks in goats. Blood samples were taken from the jugular vein at 4-week intervals. Both animal species in the Zn groups had higher plasma Zn values than the controls throughout the experimental period, except in the 4th week in goats. However, the levels of serum total thyroxine (T 4 ) and triiodothyronine (T 3 ) were lower in the lambs and goats of the Zn groups, except in the 4th week, as compared to those in the controls. Moreover, serum total thyroid hormone levels of the goats were higher at the 4th week than at the 8th week. Although there was a decrease in the levels of free thyroxine and triiodothyronine of both small ruminant species in the Zn groups when compared to the controls, these alterations were not statistically significant. These results may show that zinc supplementation to the diet at this dose reduces total thyroid hormone levels in small ruminants but does not yet impair the euthyroid status of the organism.

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“…Tetapi pada kenyataannya kadar seng serum rata-rata sangat rendah. Hal ini mungkin bisa disebabkan adanya suatu kemampuan yang tinggi untuk mendistribusikan kembali seng ke beberapa jaringan yang paling memerlukan (15).…”

Section: Hasil Penelitianunclassified

Hubungan Kadar Seng Serum Dengan Tinggi Badan Anak Sekolah Dasar Penderita Gaky

Setijowati

2013

JKB

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The incidence goiter starts to the extend in Urban area. Not all Elementary School children with goiter experience of pursued growth. This indicates that besides low iodine content, there are other elements which also influence growth. This research intends to study the relationship between zinc the level of serum and height on elementary school children (8 -12 year) in endemic goitre areas, in Malang Municipality. Data ware collected with cross-sectional study from August to December 2000. Blood and urine sample of twenty children of each group were examined for zinc serum and iodine urine concentration. Information about diet pattern, socio-economical condition were obtained by structured questionairre for mother and children.This research used Independent T-test, Person Correlation test, and Multiple Regression for statistics analysis. The result showed that: (1). There were significant relationships between energy (r = 0.364, p = 0.012); protein (r = 0.481, p = 0.001) and zinc intake (r = 0.491, p = 0.001) with height; (2). There were significant difference in energy (p = 0.014), carbohydrate (p = 0.042), lipid ( p = 0.014), protein (p = 0.003), and zinc intake (p = 0.004) between the two groups examined. The conclusion was that lower height for age was possibly ascribed to lack of energy, protein, iodine and zinc intake.

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Single and Multiple Selenium-Zinc-Iodine Deficiencies Affect Rat Thyroid Metabolism and Ultrastructure

Cited by 71 publications

References 32 publications

Effect of supplementation of various selenium forms and doses on selected parameters of ruminal fluid and blood in sheep

Effect of supplementation of various selenium forms and doses on selected parameters of ruminal fluid and blood in sheep

Zinc supplementation decreases total thyroid hormone concentration in small ruminants

Hubungan Kadar Seng Serum Dengan Tinggi Badan Anak Sekolah Dasar Penderita Gaky

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