Single-Artery Human Ear Graft Procurement: A Simplified Approach

Duisit, Jérôme; Amiel, Hadrien; Debluts, Donovan; Maistriaux, Louis; Gerdom, Alexander; Bol, Anne; Gianello, Pierre; Behets, Catherine; Lengelé, Benoît

doi:10.1097/prs.0000000000003591

Cited by 10 publications

(2 citation statements)

References 18 publications

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“…The current challenge is to find a correct and versatile decellularizing protocol applicable to each tissue type that presents different sensitivity to decellularizing agents. Additional early VCE studies employing PDR techniques have led to encouraging results in the rat limb and face ( Jank et al, 2015 ; Duisit et al, 2018 ), porcine ear ( Duisit et al, 2017a ), human face and ear ( Duisit et al, 2017b ; Duisit et al, 2017c ), human hand ( Gerli et al, 2018 ), or sheep uterus ( Tiemann et al, 2020 ). Produced matrices of various origins, sizes, and complexities show preservation of the ECM and their associated vascular tree to allow partial in vitro recellularization and in vivo transplantation.…”

Section: Vascularized Composite Tissue Engineeringmentioning

confidence: 99%

Regenerative medicine technologies applied to transplant medicine. An update

Petrosyan

Montali²,

Peloso³

et al. 2022

Front. Bioeng. Biotechnol.

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Regenerative medicine (RM) is changing how we think and practice transplant medicine. In regenerative medicine, the aim is to develop and employ methods to regenerate, restore or replace damaged/diseased tissues or organs. Regenerative medicine investigates using tools such as novel technologies or techniques, extracellular vesicles, cell-based therapies, and tissue-engineered constructs to design effective patient-specific treatments. This review illustrates current advancements in regenerative medicine that may pertain to transplant medicine. We highlight progress made and various tools designed and employed specifically for each tissue or organ, such as the kidney, heart, liver, lung, vasculature, gastrointestinal tract, and pancreas. By combing both fields of transplant and regenerative medicine, we can harbor a successful collaboration that would be beneficial and efficacious for the repair and design of de novo engineered whole organs for transplantations.

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Section: Vascularized Composite Tissue Engineeringmentioning

confidence: 99%

Regenerative medicine technologies applied to transplant medicine. An update

Petrosyan

Montali²,

Peloso³

et al. 2022

Front. Bioeng. Biotechnol.

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“…including the human hand, face and face subunits [25][26][27][28][29]. As one of the major objectives of RM is to identify an inexhaustible source of organs, animals may be considered an ideal source of aECMs for intra-abdominal and intra-thoracic bioengineering, whereas human donors should provide organs for limb, face and face subunit bioengineering for obvious reasons.…”

Section: Rm Technologies Applied To Organ Transplantationmentioning

confidence: 99%

Rethinking Regenerative Medicine From a Transplant Perspective (and Vice Versa)

et al. 2019

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No field in health sciences has more interest than organ transplantation in fostering progress in regenerative medicine (RM) because the future of no other field more than the future of organ transplantation will be forged by progress occurring in RM. In fact, the most urgent needs of modern transplant medicine - namely, more organs to satisfy the skyrocketing demand and immunosuppression-free transplantation -, cannot be met in full with current technologies and are at risk of remaining elusive goals. Instead, in the past few decades, groundbreaking progress in RM is suggesting a different approach to the problem. New, RM-inspired technologies among which decellularization, 3D printing and interspecies blastocyst complementation, promise organoids manufactured from patients' own cells and bear potential to render the use of currently used allografts obsolete. Transplantation, a field that has traditionally been immunology-based, is therefore destined to become a RM-based discipline.However, the contours of RM remain unclear, mainly due to the lack of a universally accepted definition, the lack of clarity of its potential modalities of application and the unjustified and misleading hype that often follows the reports of clinical application of RM technologies. All this generates excessive and unmet expectations and an erroneous perception of what RM really is and can offer.In this manuscript, we will (i) discuss these aspects of RM and transplant medicine, (ii) propose a definition of RM, and (iii) illustrate the state of the art of the most promising RM-based technologies of transplant interest.

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