Single atoms and small clusters of atoms may accompany Au and Pd dendrimer-encapsulated nanoparticles

Strasser, Juliette W.; Crooks, Richard M.

doi:10.1039/d2sm00518b

Cited by 5 publications

(8 citation statements)

References 41 publications

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“…It was also demonstrated that curcumin-conjugated bimetallic DENs can be selectively taken up by microglial cells in the brain, suggesting that they may be beneficial in the treatment of brain cancer [ 128 ]. Additionally, recent research has demonstrated that bimetallic DENs are capable of serving as miRNA carriers [ 23 , 129 , 130 , 131 ]. Intravenously injected Au–Pd DENs were also able to deliver miRNA to EGFR-expressing cancer tissues [ 132 ].…”

Section: Dendrimers and Inorganic Nanoparticlesmentioning

confidence: 99%

Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer

2023

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The formulation of nanoscale systems with well-defined sizes and shapes is of great interest in applications such as drug and gene delivery, diagnostics and imaging. Dendrimers are polymers that have attracted interest due to their size, shape, branching length, amine density, and surface functionalities. These unique characteristics of dendrimers set them apart from other polymers, their ability to modify nanoparticles (NPs) for biomedical applications. Dendrimers are spherical with multiple layers over their central core, each representing a generation. Their amphiphilic nature and hollow structure allow for the incorporation of multiple drugs or genes, in addition to enabling easy surface modification with cellular receptor-targeting moieties to ensure site-specific delivery of therapeutics. Dendrimers are employed in chemotherapeutic applications for the delivery of anticancer drugs. There are many inorganic NPs currently being investigated for cancer therapy, each with their own unique biological, chemical, and physical properties. To favor biomedical applications, inorganic NPs require suitable polymers to ensure stability, biodegradability and target specificity. The success of dendrimers is dependent on their unique structure, good bioavailability and stability. In this review, we describe the properties of dendrimers and their use as modifiers of inorganic NPs for enhanced therapeutic delivery. Herein, we review the significant developments in this area from 2015 to 2022. Databases including Web of Science, Scopus, Google Scholar, Science Direct, BioMed Central (BMC), and PubMed were searched for articles using dendrimers, inorganic nanoparticles and cancer as keywords.

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Section: Dendrimers and Inorganic Nanoparticlesmentioning

confidence: 99%

Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer

2023

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“…9 (a) Absorption and photoluminescence (PL) spectra of pyrene core-dendrimer (10). (b) Fluorescence behavior of pyrene-amine-containing dendrimer (11).…”

Section: Pyrene-based Dendrimersmentioning

confidence: 99%

“…(b) Structure of amphiphilic dendrimers (15). addition, the 1,4,7,10-tetraazacyclododecane (cyclen) unit of a pyrene-based dendrimer (11) was studied using steady-state uorescence and single-photon counting uorescence. Pyrenelabeled signals from the molecules were recorded in each solvent and showed the expected uorescence spectra.…”

Section: Pyrene-based Dendrimersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…9,10 Because of the near spatial closeness to neighbouring moieties, each photoactive group inside a dendrimer might have substantially different emission and energy-transfer properties compared to those of the same chromophore within small molecules. 11 For instance, in properly designed dendrimers, photoexcited chromophores can transfer energy to other units, directing the energy through the antenna framework toward the core, which can be the basis for solar energy conversion, luminescent sensors, and photoinduced electron transfer (PET) between the dendrimer units. [12][13][14] This technique can also produce the important species excimer and exciplex, which have incredibly distinct emission wavelengths within the dendrimer.…”

Section: Introductionmentioning

confidence: 99%

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Review of photoresponsive and glycoside dendrimers in biomaterials and sensors applications

2022

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Colloidal Polymer‐Templated Formation of Inorganic Nanocrystals and their Emerging Applications

Chen

Qiu

Peng

et al. 2023

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Inorganic nanocrystals possess unique physicochemical properties compared to their bulk counterparts. Stabilizing agents are commonly used for the preparation of inorganic nanocrystals with controllable properties. Particularly, colloidal polymers have emerged as general and robust templates for in situ formation and confinement of inorganic nanocrystals. In addition to templating and stabilizing inorganic nanocrystals, colloidal polymers can tailor their physicochemical properties such as size, shape, structure, composition, surface chemistry, and so on. By incorporating functional groups into colloidal polymers, desired functions can be integrated with inorganic nanocrystals, advancing their potential applications. Here, recent advances in the colloidal polymer‐templated formation of inorganic nanocrystals are reviewed. Seven types of colloidal polymers, including dendrimer, polymer micelle, stare‐like block polymer, bottlebrush polymer, spherical polyelectrolyte brush, microgel, and single‐chain nanoparticle, have been extensively applied for the synthesis of inorganic nanocrystals. Different strategies for the development of these colloidal polymer‐templated inorganic nanocrystals are summarized. Then, their emerging applications in the fields of catalysis, biomedicine, solar cells, sensing, light‐emitting diodes, and lithium‐ion batteries are highlighted. Last, the remaining issues and future directions are discussed. This review will stimulate the development and application of colloidal polymer‐templated inorganic nanocrystals.

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Single atoms and small clusters of atoms may accompany Au and Pd dendrimer-encapsulated nanoparticles

Abstract: Au and Pd dendrimer-encapsulated nanoparticles (DENs) were characterized using aberration-corrected scanning transmission electron microscopy and energy dispersive spectroscopy. The results revealed single atoms and small clusters alongside the DENs.

Cited by 5 publications

References 41 publications

Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer

Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer

Review of photoresponsive and glycoside dendrimers in biomaterials and sensors applications

Colloidal Polymer‐Templated Formation of Inorganic Nanocrystals and their Emerging Applications

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