2019
DOI: 10.1007/s10815-018-01399-1
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Single best euploid versus single best unknown-ploidy blastocyst frozen embryo transfers: a randomized controlled trial

Abstract: Purpose This paper aims to investigate the efficacy of IVF with preimplantation genetic testing for aneuploidy (PGT-A), using only best-scoring blastocysts from young (≤ 35 years) infertile patients undergoing single blastocyst frozen embryo transfers (FET). Method In this randomized controlled trial (RCT) registered 29 March 2017, 302 infertile patient-couples eligible to participate underwent autologous ICSI blastocyst freeze-all cycles. Two-hundred and twenty patient-couples satisfied the inclusion criteria… Show more

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Cited by 64 publications
(64 citation statements)
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References 46 publications
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“…In the PGT-A group, 73.4% of all blastocysts were diagnosed as euploid, suggesting that the best-scoring blastocysts of the selected infertile patient (≤35 years) group had the same probability to be healthy. The live birth rate in euploid subgroup was found not to be statistically different as compared to morphology group (56.3% vs. 58.6%), which suggests that PGT-A is not able to enhance LB rate in young patients [136].…”
Section: Pgt In a Good-prognosis Patients Undergoing Setmentioning
confidence: 70%
See 1 more Smart Citation
“…In the PGT-A group, 73.4% of all blastocysts were diagnosed as euploid, suggesting that the best-scoring blastocysts of the selected infertile patient (≤35 years) group had the same probability to be healthy. The live birth rate in euploid subgroup was found not to be statistically different as compared to morphology group (56.3% vs. 58.6%), which suggests that PGT-A is not able to enhance LB rate in young patients [136].…”
Section: Pgt In a Good-prognosis Patients Undergoing Setmentioning
confidence: 70%
“…A recently published randomized clinical trial by Ozgur et al [136] divided 220 patients aged ≤35 years in an arm, in which a single euploid blastocyst was transferred and an arm in which single unknown-ploidy blastocysts were transferred. In the PGT-A group, 73.4% of all blastocysts were diagnosed as euploid, suggesting that the best-scoring blastocysts of the selected infertile patient (≤35 years) group had the same probability to be healthy.…”
Section: Pgt In a Good-prognosis Patients Undergoing Setmentioning
confidence: 99%
“…For example, with single embryo transfer (SET) now plainly in view, wondering about live birth outcomes (LBR) following biopsy can be teased apart with much greater resolution than that used by the technology's forebears. From last month's issue, this was exactly the subject of the paper by Coetzee and colleagues that found whether or not PGT-A was done in a controlled SET setting did not matter in terms of LBR outcomes [3]. Extending this approach to the use of vitrified blastocysts, some benefit of PGT-A accrues in a recent study; outcome data at the level of LBRs is wanting to date, but will hopefully define some level of benefit in the decision-making for what patients are most likely to gain from PGT-A [4] as other encouraging results indicate [5].…”
Section: Sydney Brennermentioning
confidence: 98%
“…There are five published RCTs that have examined the impact of PGT-A with TE biopsy on the outcome of the first embryo transfer (Forman et al, 2013;Munné et al, 2019;Ozgur et al, 2019;R. J. Scott et al, 2013;Yang et al, 2012), two of which have published subsequent follow-up studies reporting on the cumulative outcomes up to one additional FET (Forman et al, 2014;Yang et al, 2013).…”
Section: Evidence For Use In Clinical Practice Pgt-a and Infertilitymentioning
confidence: 99%
“…A sixth RCT of PGT-A was not included in this review because PGT-A was not used for embryo selection purposes as only the single best blastocyst (as per morphologic scoring) underwent PGT-A in the treatment arm (Ozgur et al, 2019).…”
Section: Evidence For Use In Clinical Practice Pgt-a and Infertilitymentioning
confidence: 99%