Single-Cell Biopsy using Nanopipettes

Actis, Paolo; Kan, Shahid Y.; Penfold, Catherine; Vilozny, Boaz; Pourmand, Nader

doi:10.1016/j.bpj.2011.11.1027

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Micro/nanomanipulation Methods For Single-cell Surgery1

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2022

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“…Given their low cost and easy fabrication, microneedles have been widely used in single-cell surgical methodologies. Microneedles attached to a micromanipulator have been used for several cell surgical tasks, such as cell biopsy 70 , cell injection 71 , cell cutting 72 , patch clamping 73 and organelle removal and transfer 74 . Cell injection is the procedure of injecting external materials into a cell by a microneedle-based microinjection system 75 .…”

Section: Micro/nanomanipulation Methods For Single-cell Surgerymentioning

confidence: 99%

Advanced tools and methods for single-cell surgery

et al. 2022

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Highly precise micromanipulation tools that can manipulate and interrogate cell organelles and components must be developed to support the rapid development of new cell-based medical therapies, thereby facilitating in-depth understanding of cell dynamics, cell component functions, and disease mechanisms. This paper presents a literature review on micro/nanomanipulation tools and their control methods for single-cell surgery. Micromanipulation methods specifically based on laser, microneedle, and untethered micro/nanotools are presented in detail. The limitations of these techniques are also discussed. The biological significance and clinical applications of single-cell surgery are also addressed in this paper.

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