2024
DOI: 10.1101/2024.09.06.611519
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Single cell genome and epigenome co-profiling reveals hardwiring and plasticity in breast cancer

Kaile Wang,
Yun Yan,
Heba Elgamal
et al.

Abstract: Understanding the impact of genetic alterations on epigenomic phenotypes during breast cancer progression is challenging with unimodal measurements. Here, we report wellDA-seq, the first high-genomic resolution, high-throughput method that can simultaneously measure the whole genome and chromatin accessibility profiles of thousands of single cells. Using wellDA-seq, we profiled 22,123 single cells from 2 normal and 9 tumors breast tissues. By directly mapping the epigenomic phenotypes to genetic lineages acros… Show more

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