2021
DOI: 10.3390/metabo11110729
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Single-Cell Multiomics Analysis for Drug Discovery

Abstract: Given the heterogeneity seen in cell populations within biological systems, analysis of single cells is necessary for studying mechanisms that cannot be identified on a bulk population level. There are significant variations in the biological and physiological function of cell populations due to the functional differences within, as well as between, single species as a result of the specific proteome, transcriptome, and metabolome that are unique to each individual cell. Single-cell analysis proves crucial in … Show more

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Cited by 22 publications
(7 citation statements)
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“…Studying the functional and compositional heterogeneity caused by drug treatment at the SC level remains challenging in drug discovery and development 42 , 43 . In our proof-of-principle study, the PSC cells were treated with MF-438, a stearoyl-CoA desaturase 1 (SCD1) inhibitor which inhibits the conversion of saturated fatty acid (SFA) to monounsaturated fatty acid (MUFA) 44 .…”
Section: Resultsmentioning
confidence: 99%
“…Studying the functional and compositional heterogeneity caused by drug treatment at the SC level remains challenging in drug discovery and development 42 , 43 . In our proof-of-principle study, the PSC cells were treated with MF-438, a stearoyl-CoA desaturase 1 (SCD1) inhibitor which inhibits the conversion of saturated fatty acid (SFA) to monounsaturated fatty acid (MUFA) 44 .…”
Section: Resultsmentioning
confidence: 99%
“…In recent years, drug discovery and development based on systems biology have attracted increasing interest in the scientific and industrial fields [ 179 , 180 ]. Human disease models and multi-layered omics data can improve the success rate of drug development and predict the safety and efficacy of drugs in patients [ 181 ]. Systems biology is a powerful tool for deepening understanding of diseases, such as neurodegenerative diseases [ 182 ] and cancer [ 183 ].…”
Section: Discussionmentioning
confidence: 99%
“…Early stage strategies include limiting dilution [ 48 ], fluorescence-activated cell sorting (FACS) [ 49 ], micromanipulation using an inverted microscope, and the use of motorised micromanipulation or laser microdissection [ 50 ]. Although every method has its advantages, their shortcomings are also evident, including the complex procedures, high capture cost, lack of suitability for micro samples, and susceptibility to errors during calculations [ 51 ]. In recent years, single-cell sequencing has entered has considerably progressed.…”
Section: Technologymentioning
confidence: 99%