Single-Cell RNA Expression Profiling of ACE2 and AXL in the Human Maternal-Fetal Interface

Zheng, Qi-Teng; Duan, Tao; Jin, Liping

doi:10.4103/2096-2924.278679

Cited by 99 publications

(48 citation statements)

References 13 publications

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“…The two cases in our study showed that there is still insufficient evidence supporting maternal-fetal vertical transmission of COVID-19 in late pregnancy, and there is no evidence that vaginal delivery would increase the possibility of neonatal infection. Our results are consistent with those of Chen HJ et al [14] and Zheng QL et al [15] Chen HJ et al reported 9 pregnant women infected with COVID-19 in late pregnancy, but there was no obvious evidence supporting intrauterine infection via vertical transmission [14]. It is worth noting that all nine pregnant women underwent cesarean section with several obstetrical indications.…”

Section: Discussionsupporting

confidence: 91%

Vaginal delivery in women with COVID-19: report of two cases

Cao¹,

Chen

Peng³

et al. 2020

BMC Pregnancy Childbirth

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Background During the ongoing global outbreak of COVID-19, pregnant women who are susceptible to COVID-19 should be highly concerned. The issue of vertical transmission and the possibility of neonatal infection is a major concern. Case presentation Case 1: A 35-year-old pregnant woman with a gestational age of 37 weeks and 6 days was admitted to our hospital at the point of giving birth. Except for the abnormalities in her chest CT image, she was asymptomatic. She had an uncomplicated spontaneous vaginal delivery, and her infant was discharged home for isolation. Because of the positive result of the maternal swabs for SARS-CoV-2 obtained on the 2nd day after sampling, we transferred the mother to the designated hospital and followed up with her by telephone interviews. Luckily, it was confirmed on February 23 that the newborn did not develop any COVID-19 symptoms after observation for 14 days after birth. Case 2: Another pregnant woman, with a gestational age of 38 weeks and 2 days, was also admitted to our hospital because of spontaneous labor with cervical dilation of 5 cm. Since she had the typical manifestations of COVID-19, including cough, lymphopenia, and abnormal chest CT images, she was highly suspected of having COVID-19. Based on the experience from case 1, we helped the mother deliver a healthy baby by vaginal delivery. On the 2nd day after delivery, the maternal nasopharyngeal swab result was positive, while the infant’s result was negative. Conclusion There is still insufficient evidence supporting maternal-fetal vertical transmission for COVID-19-infected mothers in late pregnancy, and vaginal delivery may not increase the possibility of neonatal infection.

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Section: Discussionsupporting

confidence: 91%

Vaginal delivery in women with COVID-19: report of two cases

Cao¹,

Chen

Peng³

et al. 2020

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…Nonetheless, a recent study revealed that fetal infection could be transmitted in late pregnancy (Chen HJ et al, 2020). These observations may relate to low expression of ACE2 among cells detected at the maternal-fetal interface (Zheng et al, 2020). Overall, there appears to be a minimal risk of fetal infection via known routes of vertical transmission.…”

Section: Routes Of Transmissionmentioning

confidence: 99%

An overview of COVID-19

Shi

Gang

Cai

et al. 2020

J. Zhejiang Univ. Sci. B

519

332

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Pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection emerged in Wuhan City, Hubei Province, China in December 2019. By Feb. 11, 2020, the World Health Organization (WHO) officially named the disease resulting from infection with SARS-CoV-2 as coronavirus disease 2019 (COVID-19). COVID-19 represents a spectrum of clinical manifestations that typically include fever, dry cough, and fatigue, often with pulmonary involvement. SARS-CoV-2 is highly contagious and most individuals within the population at large are susceptible to infection. Wild animal hosts and infected patients are currently the main sources of disease which is transmitted via respiratory droplets and direct contact. Since the outbreak, the Chinese government and scientific community have acted rapidly to identify the causative agent and promptly shared the viral gene sequence, and have carried out measures to contain the epidemic. Meanwhile, recent research has revealed critical aspects of SARS-CoV-2 biology and disease pathogenesis; other studies have focused on epidemiology, clinical features, diagnosis, management, as well as drug and vaccine development. This review aims to summarize the latest research findings and to provide expert consensus. We will also share ongoing efforts and experience in China, which may provide insight on how to contain the epidemic and improve our understanding of this emerging infectious disease, together with updated guidance for prevention, control, and critical management of this pandemic.

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“…Recent data indicated that angiotensin-converting enzyme-2 receptors have very low expression in the placenta, which makes the chance of SARS-CoV-2 vertical transmission likely impossible [10]. Chen et al's research indicated that the placenta of infected mother lacked the morphological changes related to virus infection, and SARSCoV-2 nucleic acid in placenta was undetectable [11].…”

Section: Zero Neonate Infection Ratementioning

confidence: 99%

Clinical characteristics of 19 neonates born to mothers with COVID-19

et al. 2020

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The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19. Nineteen neonates were admitted to Tongji Hospital from January 31 to February 29, 2020. Their mothers were clinically diagnosed or laboratory-confirmed with COVID-19. We prospectively collected and analyzed data of mothers and infants. There are 19 neonates included in the research. Among them, 10 mothers were confirmed COVID-19 by positive SARS-CoV-2 RT-PCR in throat swab, and 9 mothers were clinically diagnosed with COVID-19. Delivery occurred in an isolation room and neonates were immediately separated from the mothers and isolated for at least 14 days. No fetal distress was found. Gestational age of the neonates was 38.6 AE 1.5 weeks, and average birth weight was 3293 AE 425 g. SARS-CoV-2 RT-PCR in throat swab, urine, and feces of all neonates were negative. SARS-CoV-2 RT-PCR in breast milk and amniotic fluid was negative too. None of the neonates developed clinical, radiologic, hematologic, or biochemical evidence of COVID-19. No vertical transmission of SARS-CoV-2 and no perinatal complications in the third trimester were found in our study. The delivery should occur in isolation and neonates should be separated from the infected mothers and care givers.

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Single-Cell RNA Expression Profiling of ACE2 and AXL in the Human Maternal-Fetal Interface

Cited by 99 publications

References 13 publications

Vaginal delivery in women with COVID-19: report of two cases

Vaginal delivery in women with COVID-19: report of two cases

An overview of COVID-19

Clinical characteristics of 19 neonates born to mothers with COVID-19

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