Single-cell RNA sequencing reveals distinct T cell populations in immune-related adverse events of checkpoint inhibitors

Bukhari, Shoiab; Henick, Brian S.; Winchester, Robert; Lerrer, Shalom; Adam, Kieran; Gartshteyn, Yevgeniya; Maniar, Rohan; Lin, Ziyan; Khodadadi‐Jamayran, Alireza; Tsirigos, Aristotelis; Salvatore, Mary M.; Lagos, Galina G.; Reiner, Steven L.; Dallos, Matthew C.; Mathew, Matthen; Rizvi, Naiyer A.; Mor, Adam

doi:10.1016/j.xcrm.2022.100868

Cited by 29 publications

(40 citation statements)

References 36 publications

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“… 9 , 10 In this study, Bukhari et al. 1 expand the spectrum of T cell sub-clusters associated with arthritis, pneumonitis, and thyroiditis by profiling T cells in blood samples from ICI-treated cancer patients.…”

Section: Main Textmentioning

confidence: 97%

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Distinct T cell sub-clusters may serve as biomarkers for immune related adverse events

Jing

Yang

Han

2023

Cell Reports Medicine

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Section: Main Textmentioning

confidence: 97%

“…Bukhari et al. 1 identified significant associations between different peripheral T cell sub-clusters and arthritis, pneumonitis, and thyroiditis.…”

mentioning

confidence: 99%

Distinct T cell sub-clusters may serve as biomarkers for immune related adverse events

Jing

Yang

Han

2023

Cell Reports Medicine

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“…In contextual terms, the CD28 super-family of regulatory leukocyte receptors includes ICOS, CD28, CTLA4, PD-1, and BTLA, of which CD28 is a co-stimulatory T cell activation molecule for B cell ligands CD80 and CD86, compared to PD-1 as an inhibitory receptor for PD-L1/PD-L2. Recently, it has been observed that immunocompromised cohorts with immune-related pneumonitis possess more CD4 T H 2 cells expressing CCR7, but also that CXCR3 + GATA3 is preferentially expressed [ 355 ]. Initially, it was proposed that immunity could be divided into three types, in short, initially, IFN-γ producing cells (NK cells, T C and T H 1) regulating activation of monocytes; secondly, T C and T H 2 regulation of mast cells, basophils, and eosinophils through IgE; and a third type mediated by RORγt + T cells and T H 17 regulation of monocytes and neutrophils [ 70 , 356 ].…”

Section: T Cells and The Adaptive Immune System In Sars-cov-2 Researchmentioning

confidence: 99%

“…Illustrated below (see Figure 12 ) are interactions of T C cells and relevant cytokines. As we discussed, it can now be seen that further information is available on these cells, which are decreased in immunocompromised cohorts with immune-related arthritis that have lower levels of CD8 T CM cells [ 355 ].…”

Section: T Cells and The Adaptive Immune System In Sars-cov-2 Researchmentioning

confidence: 99%

“…AITDs emerge via epigenetic and gene-environment interactions, and affected individuals are at risk for additional autoimmune diseases through associated genes, including immunoregulators (e.g., HLA, CTLA-4) and thyroid specific components (e.g., TSH receptors, thyroglobulin, and others). Individuals with immune-related thyroiditis have more CD4 T H 17 cells at baseline [ 355 ]. T H 1, T H 2, T H 17, T H 22, and T H 9 lymphocytes are involved in AITD development, as well as T REGS cells.…”

Section: T Cells and The Adaptive Immune System In Sars-cov-2 Researchmentioning

confidence: 99%

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Innate and Adaptive Immunity during SARS-CoV-2 Infection: Biomolecular Cellular Markers and Mechanisms

Brown¹,

Ojha²,

Fricke³

et al. 2023

Vaccines

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The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, other human coronaviruses (hCoVs) exist. Historical pandemics include smallpox and influenza, with efficacious therapeutics utilized to reduce overall disease burden through effectively targeting a competent host immune system response. The immune system is composed of primary/secondary lymphoid structures with initially eight types of immune cell types, and many other subtypes, traversing cell membranes utilizing cell signaling cascades that contribute towards clearance of pathogenic proteins. Other proteins discussed include cluster of differentiation (CD) markers, major histocompatibility complexes (MHC), pleiotropic interleukins (IL), and chemokines (CXC). The historical concepts of host immunity are the innate and adaptive immune systems. The adaptive immune system is represented by T cells, B cells, and antibodies. The innate immune system is represented by macrophages, neutrophils, dendritic cells, and the complement system. Other viruses can affect and regulate cell cycle progression for example, in cancers that include human papillomavirus (HPV: cervical carcinoma), Epstein–Barr virus (EBV: lymphoma), Hepatitis B and C (HB/HC: hepatocellular carcinoma) and human T cell Leukemia Virus-1 (T cell leukemia). Bacterial infections also increase the risk of developing cancer (e.g., Helicobacter pylori). Viral and bacterial factors can cause both morbidity and mortality alongside being transmitted within clinical and community settings through affecting a host immune response. Therefore, it is appropriate to contextualize advances in single cell sequencing in conjunction with other laboratory techniques allowing insights into immune cell characterization. These developments offer improved clarity and understanding that overlap with autoimmune conditions that could be affected by innate B cells (B1+ or marginal zone cells) or adaptive T cell responses to SARS-CoV-2 infection and other pathologies. Thus, this review starts with an introduction into host respiratory infection before examining invaluable cellular messenger proteins and then individual immune cell markers.

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Immune‐related adverse events in non‐small cell lung cancer: Occurrence, mechanisms and therapeutic strategies

Lin,

Xie,

Yao

et al. 2024

Clinical & Translational Med

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The emergence of immune checkpoint inhibitors (ICIs) has heralded a transformative era in the therapeutic landscape of non‐small cell lung cancer (NSCLC). While ICIs have demonstrated clinical efficacy in a portion of patients with NSCLC, these treatments concurrently precipitate a spectrum of immune‐related adverse events (irAEs), encompassing mild to severe manifestations, collectively posing a risk of significant organ damage. Consequently, there exists an imperative to augment our comprehension of the pathophysiological underpinnings of irAEs and to formulate more efficacious preventive and ameliorative strategies. In this comprehensive review, we delineate the clinical presentation of organ‐specific irAEs in patients with NSCLC and provide an in‐depth analysis of recent advancements in understanding the mechanisms driving ICI‐induced toxicity. Furthermore, we discuss potential strategies and targets for ameliorating these irAEs. Ultimately, this review aims to furnish valuable insights to guide further research endeavours in the context of irAEs in NSCLC patients.

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Single-cell RNA sequencing reveals distinct T cell populations in immune-related adverse events of checkpoint inhibitors

Cited by 29 publications

References 36 publications

Distinct T cell sub-clusters may serve as biomarkers for immune related adverse events

Distinct T cell sub-clusters may serve as biomarkers for immune related adverse events

Innate and Adaptive Immunity during SARS-CoV-2 Infection: Biomolecular Cellular Markers and Mechanisms

Immune‐related adverse events in non‐small cell lung cancer: Occurrence, mechanisms and therapeutic strategies

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