Single-cell sequencing combined with Bulk RNA-Seq to explore the molecular mechanism of cell communication in atrial fibrillation
Yilin Wu,
Zhaoxu Zhong,
Qiuyun Chen
et al.
Abstract:Atrial fibrillation (AF) represents a rapid atrial arrhythmia and is associated with the potential for adverse cardiovascular outcomes, the precise pathophysiological mechanisms underpinning AF remain incompletely elucidated. In the present study, the single-cell dataset GSE224995 was retrieved from the Gene Expression Omnibus (GEO) database, and its utilization facilitated the identification of cell subtypes involved in AF. Weighted Gene Co-expression Network Analysis (WGCNA) was constructed to systematically… Show more
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