2023
DOI: 10.1111/cpr.13433
|View full text |Cite
|
Sign up to set email alerts
|

Single‐cell transcriptomics implicates the FEZ1–DKK1 axis in the regulation of corneal epithelial cell proliferation and senescence

Abstract: Limbal stem/progenitor cells (LSC) represent the source of corneal epithelium renewal. LSC proliferation and differentiation are essential for corneal homeostasis, however, the regulatory mechanism remains largely unexplored. Here, we performed single‐cell RNA sequencing and discovered proliferation heterogeneity as well as spontaneously differentiated and senescent cell subgroups in multiply passaged primary LSC. Fasciculation and elongation protein zeta 1 (FEZ1) and Dickkopf‐1 (DKK1) were identified as two s… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(1 citation statement)
references
References 48 publications
0
1
0
Order By: Relevance
“…Seven-week-old male C57BL/6 wild-type mice (Shanghai Laboratory Animal Center, Shanghai, China) were used for these experiments. 10 The protocol was approved by the Ethics Committee of The Second Affiliated Hospital of Fujian Medical University (2023215), and all animals were treated according to the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research.…”
Section: Methodsmentioning
confidence: 99%
“…Seven-week-old male C57BL/6 wild-type mice (Shanghai Laboratory Animal Center, Shanghai, China) were used for these experiments. 10 The protocol was approved by the Ethics Committee of The Second Affiliated Hospital of Fujian Medical University (2023215), and all animals were treated according to the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research.…”
Section: Methodsmentioning
confidence: 99%