2023
DOI: 10.1101/2023.12.18.572281
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Single-cell transcriptomics reveals heterogenous thymic dendritic cell subsets with distinct functions and requirements for thymocyte-regulated crosstalk

Jayashree Srinivasan,
Bryan R. Helm,
Yilin Yang
et al.

Abstract: SUMMARYDendritic cells (DCs) are essential for establishing central tolerance in the thymus; however, mechanisms supporting their homeostasis and activation remain unresolved. Through single-cell transcriptomics and functional assays, we identify seven thymic conventional DC (cDC) subsets and discriminate their abilities to present self-antigens and induce regulatory T cells (Tregs). Mice blocked at different stages of T-cell development reveal that CD4+single-positive (SP) and CD8SP thymocytes differentially … Show more

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