Single center experience with oxybutynin transdermal system (patch) for management of symptoms related to non-neuropathic overactive bladder in children: An attractive, well tolerated alternative form of administration

Gleason, Joseph M.; Daniels, Catherine; Williams, Kimberly; Varghese, Abby; Koyle, Martin A.; Bägli, Darius; Salle, João L. Pippi; Lorenzo, Armando J.

doi:10.1016/j.jpurol.2013.12.017

Cited by 23 publications

(11 citation statements)

References 16 publications

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“…In 2014, they reported a subjective symptomatic improvement in 96% of their patients, 69% of which had prior exposure to oral oxybutynin. 20 They stated skin irritation as the most common side effect, with a 35% occurrence rate. The transdermal system comes in the form of an adhesive patch delivering 3.9 mg of oxybutynin per day and that needs to be changed twice per week.…”

Section: Oxybutyninmentioning

confidence: 99%

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Overactive bladder in children

Ramsay¹,

Bolduc²

2017

CUAJ

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Overactive bladder (OAB) is a highly prevalent disorder in the pediatric population. This condition is especially troublesome for pediatric patients and their families when associated with incontinence, since it negatively affects self-esteem and impairs children's development. From the patient's perspective, urgency and urge incontinence can have a significant impact, negatively affecting their quality of life. For a therapy to have true benefit, changes must not only be statistically significant, but must also be perceived as meaningful by the patient. A stepwise approach is favoured to treat this pathology, starting with behavioural therapy, followed by medical management, and eventually more invasive procedures.Antimuscarinic agents are the mainstay of medical treatment for OAB. Oxybutynin is the most commonly used antimuscarinic in the pediatric population. However, some patients have a suboptimal response to antimuscarinics and many experience bothersome side effects, which have been documented with all antimuscarinics to a significantly higher degree than placebo. Although there have been reports about the use of tolterodine, fesoterodine, trospium, propiverine, and solifenacin in children, to date, only oxybutynin has been officially approved for pediatric use by medical authorities in North America. This review will address alternative treatment options for pediatric patients presenting with OAB, from conservative measures to more invasive therapies.

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Section: Oxybutyninmentioning

confidence: 99%

“…The patch needs to be applied to dry, intact skin on the abdomen, hips, or buttocks, and reapplication to the same area should be avoided within a one-week period. 20 A second partial or complete patch can be applied if the initial dosage is unsatisfactory.…”

Section: Oxybutyninmentioning

confidence: 99%

Overactive bladder in children

Ramsay¹,

Bolduc²

2017

CUAJ

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“…Oxybutynin ER utilizes a novel delivery system, which results in absorption in the large intestine, thereby bypassing the first pass metabolism in the liver, resulting in a more favorable tolerability profile . Transdermal oxybutynin circumvents “first‐pass” metabolism, which might reduce side effects . However, there are only a few case series studies, without control groups, assessing the efficacy of oxybutynin in children with OAB …”

Section: Managementmentioning

confidence: 99%

Treatment of daytime urinary incontinence: A standardization document from the International Children's Continence Society

Chang

Laecke

Bauer

et al. 2015

Neurourology and Urodynamics

129

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The final document is not a systematic literature review. It includes relevant research when available as well as experts' opinion on the current understanding of daytime incontinence in children. This document illustrates that specific treatment of DUI based on an exact diagnosis is effective. The mainstay of treatment is urotherapy, but a combination of treatment modalities is often necessary. Neurourol. Urodynam. 36:43-50, 2017. © 2015 Wiley Periodicals, Inc.

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“…Se han reportado efectos adversos en 12,5 % a 68 % de los pacientes y debe evitarse su uso en pacientes con constipación sin tratamiento (25). Se dispone de varias presentaciones de esta droga: liberación inmediata, liberación extendida, transdérmica (25,36). Es un agente antimuscarínico no selectivo por lo que su uso desencadena varios efectos adversos, más frecuentemente en niños que en adultos (boca seca, estreñimiento, visión borrosa).…”

Section: Tratamiento Farmacológico Anticolinérgicosunclassified

“…Podrían estar indicados en pacientes con disfunción detrusor-esfínter, pero no está aprobado su uso en niños. Sin embargo, existen estudios que muestran su efectividad en esta población (36,51).…”

Section: Tratamiento Farmacológico Anticolinérgicosunclassified

Evaluación y tratamiento del niño con síntomas del tracto urinario inferior (LUTS)

Guerrero-Tinoco

Cano-Martínez

Vanegas-Ruiz

2018

iatreia

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RESUMENLa disfunción miccional es un trastorno del llenado o vaciado de la vejiga en niños sin alteraciones neurológicas o anatómicas. Los síntomas del tracto urinario inferior (LUTS, por la sigla en inglés de Lower urinary tract symptoms) son un motivo frecuente de consulta con el pediatra, el nefrólogo o el urólogo pediatra, e incluso con el neurólogo y el psicólogo infantil. Se le considera una enfermedad relativamente benigna lo que en ocasiones genera desinterés entre médicos y familiares y lleva a consultas tardías e interpretación inadecuada de los síntomas. Manifestaciones como urgencia, incontinencia, enuresis, goteo posmiccional, infecciones urinarias, vulvovaginitis recurrente y constipación, en un niño sin enfermedad neurológica, deben hacer pensar al médico en disfunción miccional para enfocar oportunamente el diagnóstico, restablecer la calidad de vida del paciente, evitar las infecciones urinarias y el daño renal subsecuente e irreversible secundario a un diagnóstico tardío. Las recomendaciones actuales hacen énfasis en un enfoque menos invasivo, tratamiento conservador, manejo de la constipación y reentrenamiento vesical. Este artículo discute la evaluación, el diagnóstico y el tratamiento correctos de niños con LUTS.

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Single center experience with oxybutynin transdermal system (patch) for management of symptoms related to non-neuropathic overactive bladder in children: An attractive, well tolerated alternative form of administration

Cited by 23 publications

References 16 publications

Overactive bladder in children

Overactive bladder in children

Treatment of daytime urinary incontinence: A standardization document from the International Children's Continence Society

Evaluación y tratamiento del niño con síntomas del tracto urinario inferior (LUTS)

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