Single dose oral oxycodone and oxycodone plus paracetamol (acetominophen) for acute postoperative pain in adults

Rees, Jayne; Moore, R Andrew; McQuay, Henry J; Derry, Sheena; Gaskell, Helen

doi:10.1002/14651858.cd002763

Cited by 11 publications

(3 citation statements)

References 73 publications

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“…Currently, opioid/acetaminophen combination products contain amounts of acetaminophen ranging from 300 mg up to 750 mg. Results from some studies show that the number needed to treat for at least 50% pain relief for treatment with 15 mg oxycodone vs 5 mg oxycodone/ 325 mg acetaminophen vs 10 mg oxycodone/650 mg acetaminophen was similar which suggests that the dose of oxycodone may be lowered if acetaminophen is given [32]. Moderate acetaminophen doses in combination with oxycodone may be as effective or more effective than high doses of acetaminophen.…”

Section: Impact Of Switch To Treatment With Single Entity Opioidsmentioning

confidence: 99%

Removal of Opioid/Acetaminophen Combination Prescription Pain Medications: Assessing the Evidence for Hepatotoxicity and Consequences of Removal of These Medications

Michna¹,

Duh

Korves

et al. 2010

Pain Med

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Opioid/acetaminophen combination products are widely prescribed for the management of moderate to moderately severe pain. Acetaminophen, when improperly used, can lead to liver damage and even acute liver failure. In June 2009, an FDA advisory committee recommended elimination of prescription acetaminophen combination products because of the risk of hepatotoxicity associated with use of these medications. The FDA advisory committee reviewed numerous observational studies and adverse event reporting data. The aims of this article are to: 1) provide a summary and epidemiologic critique of the studies and evidence the FDA advisory committee reviewed; 2) examine the potential consequences, such as poorly managed pain or a shift to treatment with other medications with greater potential toxicity and/or restricted availability, if the FDA follows the advisory committee vote; and 3) outline alternate strategies the FDA should consider for reducing hepatotoxicity associated with opioid/acetaminophen combination products.

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Section: Impact Of Switch To Treatment With Single Entity Opioidsmentioning

confidence: 99%

Removal of Opioid/Acetaminophen Combination Prescription Pain Medications: Assessing the Evidence for Hepatotoxicity and Consequences of Removal of These Medications

Michna¹,

Duh

Korves

et al. 2010

Pain Med

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“…Some specific concerns about acetaminophen-induced hepatotoxicity [36] or particularly when acetaminophen is combined with opioid (e.g. codeine or hydrocodone) [5], can account for these differences. However, further investigation must be performed to completely analyze observed discrepancies.…”

Section: Scientific Aspects Of Acetaminophenmentioning

confidence: 99%

“…Part of this work was presented at the Congrès de la Société de Pharmacologie Thérapeutique Physiologie (P2T), 11-13 Avril 2007, Toulouse, France. updates are frequently published on its therapeutic [3,4] or toxicological effects when used alone [2], or in combination with opioids [5]. Additional information is regularly published from epidemiological studies [6], and a recent paper provides interested readers a comprehensive and detailed review on acetaminophen, its history, its pharmacological effects and its mechanisms of action [7].…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of the scientific literature on acetaminophen in medicine and biology: a 2003–2005 study†

Robert¹,

Saenz-Feijoo

Gaudy³

et al. 2009

Fundamemntal Clinical Pharma

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This study quantifies the utilization of acetaminophen in life sciences and clinical medicine using bibliometric indicators. A total of 1626 documents involving acetaminophen published by 74 countries during 2003-2005 in the Thompson-Scientific Life sciences and Clinical Medicine collections were identified and analyzed. The USA leads in the number of publications followed by the UK, and industrialized countries, including France, Japan and Germany; the presence of countries such as China, India and Turkey among the top 15 countries deserves to be noticed. The European Union stands as a comparable contributor to the USA, both in terms of number of publications and in terms of profile of papers distributed among subcategories of Life Sciences and Clinical Medicine disciplines. All documents were published in 539 different journals. The most prolific journals were related to pharmacology and/or pharmaceutics. All aspects of acetaminophen (chemistry, pharmacokinetics, metabolism, etc.) were studied with primary interest for therapeutic use (42%) and adverse effects (28%) comprising a large part of publications focusing on acetaminophen hepatotoxicity. This quantitative overview provides as to the interest of the scientific community in this analgesic and completes the various review documents that regularly appear in the scientific literature.

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American Pain Society Recommendations for Improving the Quality of Acute and Cancer Pain Management

et al. 2005

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Single dose oral oxycodone and oxycodone plus paracetamol (acetominophen) for acute postoperative pain in adults

Cited by 11 publications

References 73 publications

Removal of Opioid/Acetaminophen Combination Prescription Pain Medications: Assessing the Evidence for Hepatotoxicity and Consequences of Removal of These Medications

Removal of Opioid/Acetaminophen Combination Prescription Pain Medications: Assessing the Evidence for Hepatotoxicity and Consequences of Removal of These Medications

Quantitative analysis of the scientific literature on acetaminophen in medicine and biology: a 2003–2005 study†

American Pain Society Recommendations for Improving the Quality of Acute and Cancer Pain Management

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