2023
DOI: 10.1126/sciadv.adj1428
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Single-dose VSV-based vaccine protects against Kyasanur Forest disease in nonhuman primates

Bharti Bhatia,
Tsing-Lee Tang-Huau,
Friederike Feldmann
et al.

Abstract: Kyasanur Forest disease virus (KFDV) is an endemic arbovirus in western India mainly transmitted by hard ticks of the genus Haemaphysalis . KFDV causes Kyasanur Forest disease (KFD), a syndrome including fever, gastrointestinal symptoms, and hemorrhages. There are no approved treatments, and the efficacy of the only vaccine licensed in India has recently been questioned. Here, we studied the protective efficacy of a vesicular stomatitis virus (VSV)–based vaccine expressing the KFDV prec… Show more

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