Single high dose dexamethasone treatment decreases the pathological score and increases the survival rate of paraquat-intoxicated rats

Dinis-Oliveira, Ricardo Jorge; Duarte, José Alberto; Remião, Fernando; Navarro, Amparo Sánchez; Bastos, Maria de Lourdes; Carvalho, Félix

doi:10.1016/j.tox.2006.07.025

Cited by 97 publications

(64 citation statements)

References 46 publications

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“…Furthermore, various inflammatory mediators including TNF-␣ have been expected to be increased in the lung during PQ toxicity (Dinis-Oliveira et al, 2006a). It is known that TNF-␣ triggers the synthesis of leukotrienes and prostaglandin E (E 2 ) which then stimulate the infiltration of polymorphonuclear leukocytes into the lungs and cause lung injury (Dinis-Oliveira et al, 2006b).…”

Section: Discussionmentioning

confidence: 99%

The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats

Sun

Zhang²,

Yan³

et al. 2011

Environmental Toxicology and Pharmacology

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Section: Discussionmentioning

confidence: 99%

The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats

Sun

Zhang²,

Yan³

et al. 2011

Environmental Toxicology and Pharmacology

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“…These results are in accordance with those of previous experimental studies (McLeay 1973;Pirro et al, 1981;Turini et al, 2003). Meanwhile, the high dose of Dex also resulted in latent or manifest liver and kidney injury (William et al, 1963;Heimdal et al, 1992;Dinis-Oliveira et al, 2006;Eken et al, 2006). The mechanisms of glucocorticoidmediated side effects to liver and the kidney have been investigated by previous researchers (Schcke et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

PLA/PEG-PPG-PEG/Dexamethasone implant prepared by hot-melt extrusion for controlled release of immunosuppressive drug to implantable medical devices, part 2:in vivoevaluation

Li¹,

Guo²,

Deng³

et al. 2013

Drug Delivery

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Hot-melt extrusion (HME) plays an important role in preparing implants as local drug delivery systems in pharmaceutical fields. Here, a new PLA/PEG-PPG-PEG/Dexamethasone (PLA/F68/ Dex) implant prepared by HME has been developed. Importantly, the implant was successfully achieved to control release of immunosuppressive drug to an implanted device. In particular, this implant has not been reported previously in pharmaceutical fields. FTIR and XRD were adopted to investigate the properties of the samples. The in vivo release study showed that the maximum value of Dex release from the implants was approximately 50% at 1 month. The in vivo degradation behavior was determined by UV spectrophotometer and scanning electron microscopy studies, and the weight loss rate of the implants were up to 25% at 1 month. Furthermore, complete blood count (CBC) test, serum chemistry and major organs were performed, and there is no significant lesion and side effects observed in these results. Therefore, the results elucidated that the new PLA/F68/Dex implant prepared by HME could deliver an immunosuppressive drug to control the inflammatory reaction at the implant site.

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“…Corticosteroids administered by the inhaled, oral, and intraperitoneal routes upregulate the P-glycoprotein transporter. [205][206][207] A particularly good example of the i mportance of transporters in inhaled chemotherapy is the inhibition of P-glycoprotein by lipid nanocapsules, which is a crucial mechanism of resistance for paclitaxel. 208 There are nine multidrug proteins (MRPs)…”

Section: Drug Transporters Atp-binding Cassette Transportersmentioning

confidence: 99%

Inhaled chemotherapy in lung cancer: future concept of nanomedicine

Zarogoulidis

Chatzaki²,

Porpodis³

et al. 2012

IJN

168

160

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Regional chemotherapy was first used for lung cancer 30 years ago. Since then, new methods of drug delivery and pharmaceuticals have been investigated in vitro, and in animals and humans. An extensive review of drug delivery systems, pharmaceuticals, patient monitoring, methods of enhancing inhaled drug deposition, safety and efficacy, and also additional applications of inhaled chemotherapy and its advantages and disadvantages are presented. Regional chemotherapy to the lung parenchyma for lung cancer is feasible and efficient. Safety depends on the chemotherapy agent delivered to the lungs and is dose-dependent and time-dependent. Further evaluation is needed to provide data regarding early lung cancer stages, and whether regional chemotherapy can be used as neoadjuvant or adjuvant treatment. Finally, inhaled chemotherapy could one day be administered at home with fewer systemic adverse effects.

show abstract

Single high dose dexamethasone treatment decreases the pathological score and increases the survival rate of paraquat-intoxicated rats

Cited by 97 publications

References 46 publications

The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats

The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats

PLA/PEG-PPG-PEG/Dexamethasone implant prepared by hot-melt extrusion for controlled release of immunosuppressive drug to implantable medical devices, part 2:in vivoevaluation

Inhaled chemotherapy in lung cancer: future concept of nanomedicine

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