Single molecule manipulation at low temperature and laser scanning tunnelling photo-induced processes analysis through time-resolved studies

Riedel, Damien

doi:10.1088/0953-8984/22/26/264009

Cited by 16 publications

(25 citation statements)

References 26 publications

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“…x t0), where Iexc. is the excitation current, e the charge of the electron and where t0 = -Texc./ln(1-ps) is extracted from a binomial law 39,40 .…”

Section: Methods: Experimental Methodsmentioning

confidence: 99%

Probing charge transfer dynamics in a single iron tetraphenylporphyrin dyad adsorbed on an insulating surface

et al. 2018

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Although the dynamics of charge transfer (CT) processes can be probed with ultimate lifetime resolution, the inability to control CT at the nanoscale is one of the most important roadblocks to revealing some of its deep fundamental aspects. In this work, we present an investigation of CT dynamics in a single iron tetraphenylporphyrin (Fe-TPP) donor/acceptor dyad adsorbed on a CaF2/Si(100) insulating surface. The tip of a scanning tunneling microscope (STM) is used to create local ionic states in one fragment of the dyad. The CT process is monitored by imaging subsequent changes in the neighbor acceptor molecule and its efficiency is mapped, revealing the influence of the initial excited state in the donor molecule. In the validation of the experiments, simulations based on density functional theory show that holes have a higher donor-acceptor CT rate compared to electrons and highlight a noticeable initial state dependence on the CT process. We leverage the unprecedented spatial resolution achieved in our experiments to show that the CT process in the dyad is governed via molecule-molecule coherent tunneling with negligible surface-mediated character.

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“…x t0), where Iexc. is the excitation current, e the charge of the electron and where t0 = -Texc./ln(1-ps) is extracted from a binomial law 39,40 .…”

Section: Methods: Experimental Methodsmentioning

confidence: 99%

Probing charge transfer dynamics in a single iron tetraphenylporphyrin dyad adsorbed on an insulating surface

et al. 2018

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“…Sections of iBAT and ingWAT (paraffin, 5 mm thick; nZ5/group, Wax-it Histological Services) were deparaffinized and rehydrated as described previously (Riedel 2010). Antigen retrieval was completed in Tris-EDTA buffer (pH 9) for 20 min at 95 8C.…”

Section: Immunohistochemistrymentioning

confidence: 99%

PACAP is essential for the adaptive thermogenic response of brown adipose tissue to cold exposure

Diané¹,

Nikolic²,

Rudecki³

et al. 2014

Journal of Endocrinology

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Pituitary adenylate cyclase-activating polypeptide (PACAP) is a widely distributed neuropeptide that acts as a neurotransmitter, neuromodulator, neurotropic factor, neuroprotectant, secretagogue, and neurohormone. Owing to its pleiotropic biological actions, knockout of Pacap (Adcyap1) has been shown to induce several abnormalities in mice such as impaired thermoregulation. However, the underlying physiological and molecular mechanisms remain unclear. A previous report has shown that cold-exposed Pacap null mice cannot supply appropriate levels of norepinephrine (NE) to brown adipocytes. Therefore, we hypothesized that exogenous NE would rescue the impaired thermogenic response of Pacap null mice during cold exposure. We compared the adaptive thermogenic capacity of Pacap K/K to Pacap C/C mice in response to NE when housed at room temperature (24 8C) and after a 3.5-week cold exposure (4 8C). Biochemical parameters, expression of thermogenic genes, and morphological properties of brown adipose tissue (BAT) and white adipose tissue (WAT) were also characterized. Results showed that there was a significant effect of temperature, but no effect of genotype, on the resting metabolic rate in conscious, unrestrained mice. However, the normal cold-induced increase in the basal metabolic rate and NE-induced increase in thermogenesis were severely blunted in cold-exposed Pacap K/K mice. These changes were associated with altered substrate utilization, reduced b 3 -adrenergic receptor (b 3 -Ar (Adrb3)) and hormone-sensitive lipase (Hsl (Lipe)) gene expression, and increased fibroblast growth factor 2 (Fgf2) gene expression in BAT. Interestingly, Pacap K/K mice had depleted WAT depots, associated with upregulated uncoupling protein 1 expression in inguinal WATs. These results suggest that the impairment of adaptive thermogenesis in Pacap null mice cannot be rescued by exogenous NE perhaps in part due to decreased b 3 -Ar-mediated BAT activation.

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“…To establish the number of electrons required in the dissociation of CF 3 , the reaction rate was measured as a function of tunneling current following a previously established method ( 26 , 27 ). For a chosen tunneling current, the time prior to the discontinuity in the current-versus-time curve was plotted as a histogram whose bin size was set by Doane’s formula ( 28 ).…”

Section: Methodsmentioning

confidence: 99%

Approaching the forbidden fruit of reaction dynamics: Aiming reagent at selected impact parameters

et al. 2018

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Single molecule manipulation at low temperature and laser scanning tunnelling photo-induced processes analysis through time-resolved studies

Cited by 16 publications

References 26 publications

Probing charge transfer dynamics in a single iron tetraphenylporphyrin dyad adsorbed on an insulating surface

Probing charge transfer dynamics in a single iron tetraphenylporphyrin dyad adsorbed on an insulating surface

PACAP is essential for the adaptive thermogenic response of brown adipose tissue to cold exposure

Approaching the forbidden fruit of reaction dynamics: Aiming reagent at selected impact parameters

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