2023
DOI: 10.1038/s41598-023-47090-z
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Single-neuron mechanical perturbation evokes calcium plateaus that excite and modulate the network

Bogdana Cepkenovic,
Florian Friedland,
Erik Noetzel
et al.

Abstract: Mechanical stimulation is a promising means to non-invasively excite and modulate neuronal networks with a high spatial resolution. Despite the thorough characterization of the initiation mechanism, whether or how mechanical responses disperse into non-target areas remains to be discovered. Our in vitro study demonstrates that a single-neuron deformation evokes responses that propagate to about a third of the untouched neighbors. The responses develop via calcium influx through mechanosensitive channels and re… Show more

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