Single-nucleotide polymorphism associations with preterm delivery: a case–control replication study and meta-analysis

O’Callaghan, Michael; MacLennan, Alastair H.; McMichael, G.; Haan, Eric; Dekker, Gustaaf A.

doi:10.1038/pr.2013.117

Cited by 7 publications

(2 citation statements)

References 31 publications

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“…Many of the associations reported to date lack replication, and there is substantial variation between reports, including mixed ethnicities, variable cohort sizes, differing genetic models applied and different definitions of preterm birth between studies. One recent case-control replication study found only factor V Leiden to be significantly associated with preterm birth, and meta-analysis confirmed its association (O'Callaghan et al 2013). These authors found that 980 papers had been published on SNPs and preterm birth, reviewed 78 of these and came up with eight SNPs to test as replication candidates.…”

Section: Preterm Birthmentioning

confidence: 96%

“…One recent case–control replication study found only factor V Leiden to be significantly associated with preterm birth, and meta‐analysis confirmed its association (O'Callaghan et al . ). These authors found that 980 papers had been published on SNPs and preterm birth, reviewed 78 of these and came up with eight SNPs to test as replication candidates.…”

Section: Introductionmentioning

confidence: 97%

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Insights from physiology into myometrial function and dysfunction

Wray

2015

Experimental Physiology

104

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After training in physiology at UCL, I took up a lectureship in Liverpool in 1990 and am now getting my long-service award! I enjoy exploring myometrial physiology and its interaction with metabolism, as well as thinking about how our science may be of relevance to women in labour. I also spend time mentoring female physiologists and serve as Director of Athena SWAN for my university. I am proud to have co-edited The Physiological Society's book celebrating the centenary of women being elected to the Society, and to have been a Joan Mott lecturer. New Findings r What is the topic of this review?I focus on clinical aspects of uterine physiology, specifically, myometrial contractility. I bring together and contrast findings using physiological approaches and those using newer techniques, 'omics'. r What advances does it highlight?Physiological studies have recently shed light on the myometrium in twin pregnancies, but there have been no 'omic' approaches. In contrast, studies of preterm delivery using newer approaches are generating new research avenues, whereas traditional approaches have not flourished. Finally, I describe significant advances in understanding of 'slow-to-progress' labours, achieved using physiological and clinical approaches. Advances in molecular, genetic and 'omic' technologies are fuelling the thirst for better understanding of the uterus and application of this information to problems in pregnancy and labour. Progress has, however, been limited while we still have an incomplete understanding of some of the basic physiology of uterine smooth muscle (myometrium). In this review and opinion piece, I explore some of the fascinating findings from selected recent studies and see how these may provide new avenues for physiological and clinical research. It is also the case, however, that there is still limited mechanistic understanding about physiological and pathophysiological processes in the myometrium. This lack of understanding limits the usefulness of some findings from genomic and allied studies. By focusing on some key recent findings and relating these to two important clinical problems in childbirth that involve myometrial activity, namely preterm delivery and difficult labours, the interplay between our physiological knowledge and the information provided by newer technologies is explored. My opinion is that physiology has provided much more new mechanistic insight into difficult births and that the newer

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Section: Preterm Birthmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 97%

Insights from physiology into myometrial function and dysfunction

Wray

2015

Experimental Physiology

104

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Prematurity

Kent¹

2015

Keeling’s Fetal and Neonatal Pathology

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Preterm birth is defi ned as delivery less than 37 weeks' gestational age. The rate of preterm birth varies around the world and differs between developed and developing countries. It is 12-13 % in the United States of America (USA), 5-9 % in Europe, 9 % in Australia, and as high as 18 % in some countries in Africa. In developed countries the increased rate of preterm birth has been attributed to the changing demographics of childbearing. The mean age of childbearing has increased over the years with the average age of primiparous women in Australia now 28.3 years of age and the percentage of fi rst-time mothers over 35 years of age in the USA now 4 %. Delayed childbearing is associated with a number of risk factors including preeclampsia and gestational diabetes. Infertility with the resultant use of in vitro fertilization methods and consequent twins/triplets are also signifi cant issues. Another major risk factor for preterm birth is maternal obesity, which is increasing in both developed and developing countries. Complications of maternal obesity include maternal and fetal death, preeclampsia, gestational diabetes, and congenital abnormalities. Preterm BirthPreterm birth is defi ned as delivery less than 37 weeks' gestational age. The rate of preterm birth varies around the world and differs between developed and developing countries. It is 12-13 % in the USA, 5-9 % in Europe, 9 % in Australia, and as high as 18 % in some countries in Africa [ 1 -3 ]. In 2010 more than 60 % of preterm births occurred in south Asia and sub-Saharan Africa [ 2 ]. In developed countries the increased rate of preterm birth has been attributed to the changing demographics of childbearing. The mean age of childbearing has increased over the years with the average age of primiparous women in Australia now 28.3 years of age [ 3 ] and the percentage of fi rsttime mothers over 35 years of age in the USA now 4 % [ 4 ]. Delayed childbearing is associated with a number of risk factors including preeclampsia and gestational diabetes. Infertility

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