Single Nucleotide Polymorphism rs17173608 in the Chemerin Encoding Gene: Is It a Predictor of Insulin Resistance and Severity of Coronary Artery Disease in Non-Obese Type 2 Diabetes?

Perumalsamy, Sangeetha; Ahmad, Wan Azman Wan; Huri, Hasniza Zaman

doi:10.3390/healthcare9060623

Cited by 9 publications

(13 citation statements)

References 31 publications

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“…Table 5 and Figure 4 show the association of IR and the severity of CAD in correlation with RBP-4 levels. The secondary associations of IR and the severity of CAD in correlation with clinical factors were as earlier described (PMID: 34071097) [ 5 ].…”

Section: Resultsmentioning

confidence: 99%

“…The selection of participants and inclusion and exclusion criteria were as earlier described (PMID: 34071097) [ 5 ]. This study used the same cohort as in the PMID: 34071097.…”

Section: Methodsmentioning

confidence: 99%

“…The assessments of demographic and clinical information and anthropometric measurements were as earlier described (PMID: 34071097) [ 5 ]. Laboratory investigation results, such as fasting plasma glucose (FPG), fasting plasma insulin (FPI), A1C, hs-CRP and lipid profile, the types and number of comorbidities, and details on the pharmacological treatments, were also obtained.…”

Section: Methodsmentioning

confidence: 99%

“…Biochemical parameters’ assessments were as earlier described (PMID: 34071097) [ 5 ]. Blood samples were taken after at least 8 h of fasting in the morning (7:00 a.m. to 10:00 a.m.).…”

Section: Methodsmentioning

confidence: 99%

“…The formation of atherosclerotic plaques in the coronary arteries results in atherosclerotic coronary artery disease (CAD) [ 4 ]. The CAD is defined as severe when the atherosclerotic plaques narrow down the vessels with stenosis by more than 50% [ 5 ]. The severity is also classified on the basis of the number of vessels involved as a single-vessel disease (SVD), double-vessel disease (DVD), and triple-vessel disease (TVD).…”

Section: Introductionmentioning

confidence: 99%

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Retinol-Binding Protein-4—A Predictor of Insulin Resistance and the Severity of Coronary Artery Disease in Type 2 Diabetes Patients with Coronary Artery Disease

Perumalsamy

Ahmad

Huri

2021

Biology

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(1) Background: Insulin resistance (IR) is the fundamental cause of type 2 diabetes (T2D), which leads to endothelial dysfunction and alters systemic lipid metabolism. The changes in the endothelium and lipid metabolism result in atherosclerotic coronary artery disease (CAD). In insulin-resistant and atherosclerotic CAD states, serum cytokine retinol-binding protein-4 (RBP-4) levels are elevated. The adipocyte-specific deletion of glucose transporter 4 (GLUT4) results in higher RBP-4 expression and IR and atherosclerotic CAD progression. (2) Aim: This study aimed to investigate the association of RBP-4 and clinical factors with IR and the severity of CAD. (3) Methods: Patients were recruited from diabetes and cardiology clinics and divided into three subgroups, namely (i) T2D patients with CAD, (ii) T2D-only patients, and (iii) CAD-only patients. The severity of CAD was classified as either single-vessel disease (SVD), double-vessel disease (DVD), or triple-vessel disease (TVD). An enzyme-linked immunosorbent assay was conducted to assess the concentration of serum RBP-4. Univariate (preliminary analysis) and multivariate (secondary analysis) logistic regressions were applied to assess the associations of RBP-4 and clinical factors with IR and the severity of CAD. (4) Results: Serum RBP-4 levels were associated with IR and the severity of CAD in all the three groups (all p-values are less than 0.05). Specifically, serum RBP-4 levels were associated with IR (p = 0.030) and the severity of CAD (SVD vs. DVD, p = 0.044; SVD vs. TVD, p = 0.036) in T2D patients with CAD. The clinical factors fasting plasma glucose (FPG) and angiotensin-converting-enzyme inhibitor (ACEI) were also associated with both IR and the severity of CAD in T2D patients with CAD. (5) Conclusion: RBP-4, FPG, and ACEI are predictors of IR and severity of CAD in T2D patients with CAD.

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Section: Resultsmentioning

confidence: 99%

“…The selection of participants and inclusion and exclusion criteria were as earlier described (PMID: 34071097) [ 5 ]. This study used the same cohort as in the PMID: 34071097.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Biochemical parameters’ assessments were as earlier described (PMID: 34071097) [ 5 ]. Blood samples were taken after at least 8 h of fasting in the morning (7:00 a.m. to 10:00 a.m.).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Retinol-Binding Protein-4—A Predictor of Insulin Resistance and the Severity of Coronary Artery Disease in Type 2 Diabetes Patients with Coronary Artery Disease

Perumalsamy

Ahmad

Huri

2021

Biology

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Adiponectin rs1501299 and chemerin rs17173608 gene polymorphism in children with type 1 diabetes mellitus: relation with macroangiopathy and peripheral artery disease

Salah,

Madkour,

Ahmed

et al. 2023

J Endocrinol Invest

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Aim Although macrovascular complications represent the leading cause of mortality in type 1 diabetes mellitus (T1DM), the prevalence of subtle macrovascular affection including peripheral artery disease (PAD) among children with T1DM and its genetic predictors remains to be unraveled. Increasing evidence suggests a link between adiponectin rs1501299 and chemerin rs17173608 gene polymorphism and atherogenesis, and insulin resistance. Hence, this study assess the prevalence of these variants among children with T1DM in comparison to healthy controls and their association with macrovascular complications, namely PAD and hyperlipidemia. Methods Fifty children with T1DM and 50 matched controls underwent a thorough assessment including adiponectin rs1501299 and chemerin rs17173608 gene polymorphisms, fasting lipids, glycated hemoglobin (HbA1c), and ankle–brachial index (ABI). Cochran–Armitage trend test was used to decide the risk allele and evaluate the association between the candidate variant and PAD using a case–control design. Results Children with T1DM were found to have significantly higher ABI (p = 0.011) than controls. Chemerin gene polymorphism was detected in 41 children with T1DM (82.0%), while adiponectin gene polymorphism was detected in 19 children (38.0%). Children with T1DM having GG chemerin variant and those having TT adiponectin variant had significantly higher cholesterol with significantly lower HDL-C and ABI than those having the other two variants (p < 0.005). Children with T1DM having abnormal ABI had significantly higher chemerin G (p = 0.017) and adiponectin T (p = 0.022) alleles than those with normal ABI. Cholesterol and ABI were independently associated with chemerin and adiponectin gene polymorphism by multivariable regression analysis. Conclusion Children with T1DM having chemerin and adiponectin gene polymorphisms have significantly higher cholesterol and ABI than those without these polymorphisms and controls. Trial registration The Research Ethics Committee of Ain Shams University, approval number R 31/2021.

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Single nucleotide polymorphisms: Implications in the early diagnosis and targeted intervention of coronary microvascular dysfunction

Tian,

Li,

Lai

et al. 2025

Genes & Diseases

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Single Nucleotide Polymorphism rs17173608 in the Chemerin Encoding Gene: Is It a Predictor of Insulin Resistance and Severity of Coronary Artery Disease in Non-Obese Type 2 Diabetes?

Cited by 9 publications

References 31 publications

Retinol-Binding Protein-4—A Predictor of Insulin Resistance and the Severity of Coronary Artery Disease in Type 2 Diabetes Patients with Coronary Artery Disease

Retinol-Binding Protein-4—A Predictor of Insulin Resistance and the Severity of Coronary Artery Disease in Type 2 Diabetes Patients with Coronary Artery Disease

Adiponectin rs1501299 and chemerin rs17173608 gene polymorphism in children with type 1 diabetes mellitus: relation with macroangiopathy and peripheral artery disease

Single nucleotide polymorphisms: Implications in the early diagnosis and targeted intervention of coronary microvascular dysfunction

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