Single-nucleotide polymorphisms and haplotypes in the adiponectin gene contribute to the genetic risk for type 2 diabetes in Tunisian Arabs

Mtiraoui, Nabil; Ezzidi, Intissar; Turki, Amira; Chaieb, A.; Mahjoub, Touhami; Almawi, Wassim Y.

doi:10.1016/j.diabres.2012.02.015

Cited by 43 publications

(34 citation statements)

References 36 publications

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“…In recent years, there have been many reports about the association between adiponectin SNPs and various diseases. Although previous studies have examined the role of adiponectin SNPs in obesity, T2D and CVD [11][12][13][14][15]37 . In this study, we did not find a significant association between the +45 T>G (rs2241766) in the ADIPOQ gene and MS in Tunisian population.…”

Section: Discussionmentioning

confidence: 99%

“…Our results are similar to those of others study in different ethnic populations 38,39 . However, the association of SNP +45 T>G with T2D, insulin resistance and obesity both in healthy individuals and T2D patients, has been investigated in several populations including the Tunisian ones 12,14,[40][41][42] . Interestingly, polymorphism +45T>G showed a strong association with body adiposity in diabetic women.…”

Section: Discussionmentioning

confidence: 99%

“…It consists of three exons and two introns spanning a 16 Kb 12 . In this region, genome-wide scans have mapped a susceptibility locus for T2D, coronary artery disease, insulin resistance and MS [11][12][13][14][15][16] . Several single nucleotide polymorphisms (SNP) at this locus have been reported individually or in combination as haplotypes and the most commonly studied are rs17300539 (-11391G>A) and rs266729 (-11377C>G) in the promoter region and rs2241766 (+45T>G) and rs1501299 (276G>T) in exon 2 and intron 2, respectively 17 .…”

Section: Introductionmentioning

confidence: 99%

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2017

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Adiponectin has been schown to protect from insulin resistance, demonstrate anti-inflammatory and anti-atherosclerotic effects and be involved in the pathogenesis of metabolic syndrome (MS). We aimed to assess the association between serum adiponectin concentration, insulin resistance and various risk factors of MS and to investigate the relationship between the single nucleotide polymorphism (SNP) +45 T>G ( rs 2241766) in the adiponectin (ADIPOQ) gene and the risk of MS. 200 patients with MS and 250 healthy controls were enrolled in this study. The level of fasting serum insulin, glucose, and lipid levels were measured. Insulin resistance was estimated using homeostasis model of assessment for insulin resistance (HOMA-IR). Serum adiponectin levels were measured by enzyme-linked immunosorbent assay and the SNP +45 T>G in the ADIPOQ gene was performed by the polymerase chain reaction-restriction fragment length polymorphism method. MS patients had a significantly higher levels of HOMA-IR (p<0.001) and lower serum adiponectin concentrations (p<0.001) compared to controls. Multiple regression analysis showed that serum adiponectin levels was associated negatively with HOMA-IR (r=-0.307; p=0.001) and positively with high-density lipoprotein cholesterol (HDL-C) (r=0.369; p=0.000) in MS patients. In addition, there was no significant association between genotypes of rs 2241766 and the risk of MS. In conclusion, adiponectin is known to play key regulator of insulin sensitivity, endothelial function and lipid metabolism. Our findings confirm the associations of hypoadiponectinemia with MS and gave evidence that the SNP+45 T>G polymorphism in the gene of ADIPOQ is not associated with MS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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2017

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“…There are 149 variants identified in the ADIPOQ gene (73). Although the number of variations are not directly associated with T2DM, these variations may affect insulin sensitivity in obese diabetic patients (69,74).…”

Section: Genetic Implicationsmentioning

confidence: 99%

“…Although studies on ADIPOQ genetic variations in Arab populations are still limited and there are no metaanalyses showing the frequency of Arabs carrying variants of the ADIPOQ gene, several researchers have reported that a statistically significant number of Arab obese diabetic patients carry variants of the ADIPOQ gene (73,77).…”

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Obesity-linked diabetes in the Arab world: a review

Abuyassin¹,

Laher²

2015

Easter Mediterr Health J

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Genetic variants in promoter regions associated with type 2 diabetes mellitus: A large‐scale meta‐analysis and subgroup analysis

Wang

2019

J of Cellular Biochemistry

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Background: Promoter plays important roles in regulating transcription of genes. Association studies of genetic variants in promoter region with type 2 diabetes (T2D) risk have been reported, but most were limited to small number of individual genetic variants and insufficient sample sizes. In addition, the effect of study populations and demographic characteristics were often neglected.Methods: In this study, we conducted a large-scale meta-analysis and subgroup analysis of T2D associated genetic variants in the promoter regions to evaluate their contribution to the susceptibility in T2D. Alleles and genotypes from cohort or case-controlled studies were extracted for future study. Total 41 742 cases and 50 493 controls for three loci were involved in 70 articles.Results: Seventy case-controlled studies of three genes with 41 742 cases and 50 493 controls were included. Meta-analysis showed only rs266729 and rs17300539 of ADIPOQ, and rs1884613, rs2144908, and rs4810424 of HNF4A were significantly associated with T2D risk. Subgroup analysis showed that both rs266729 and rs17300539 of ADIPOQ were associated with the risk of T2D in Caucasian population, but only rs266729 of ADIPOQ in Asian population and rs2144908 in other population including multinational North American. For diagnostic criteria, rs266729 of ADIPOQ and rs2144908 of HNF4A were associated with T2D risk when WHO/ADA diagnostic criteria were used. For genotyping methods, both rs266729 of ADIPOQ and rs2144908 of HNF4A were associated with T2D risk when other than Taqman and Sequencing methods were used. Conclusions: T2D was significantly associated with promoter rs266729, rs17300539, rs1884613, rs2144908, and rs4810424, and the association of T2D risk were affected by study population, diagnostic criteria, and genotype methods. K E Y W O R D S genetic variant, promoter, type 2 diabetes J Cell Biochem. 2019;120:13012-13025. wileyonlinelibrary.com/journal/jcb 13012 |

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Single-nucleotide polymorphisms and haplotypes in the adiponectin gene contribute to the genetic risk for type 2 diabetes in Tunisian Arabs

Cited by 43 publications

References 36 publications

Untitled

Untitled

Obesity-linked diabetes in the Arab world: a review

Genetic variants in promoter regions associated with type 2 diabetes mellitus: A large‐scale meta‐analysis and subgroup analysis

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