Single Nucleotide Polymorphisms in Adiponectin Gene Are Not Directly Associated with Increased Risk of Obstructive Sleep Apnea Syndrome in a Chinese Han Population

Abstract

Purpose: This study aims to test the possible correlation between single nucleotide polymorphisms (SNPs) in the adiponectin gene and increased risk of obstructive sleep apnea syndrome (OSAS) in a Chinese Han population. Materials and Methods: A total of 266 subjects were enrolled into the study to detect 9 SNPs in the adiponectin gene. Multivariate unconditional logistic regression analysis, adjusted for gender and age, was used to estimate the associations of these SNPs with OSAS risk. Results: No evidence of a direct association was observed between these SNPs and the risk of OSAS in the Chinese Han population. However, the stratified analysis also revealed a remarkable genotype difference for SNP rs6773957 between cases and controls in the overweight subgroup (p < 0.05). In addition, the allele or genotype distributions of rs12495941, rs182052, and rs16861205 had significant differences with regard to the severity of OSAS (p < 0.05). No differences were identified in the other subgroups. Conclusion: The current research demonstrated that the SNPs in the adiponectin gene did not represent susceptibility loci for OSAS in Chinese Han individuals overall. However, variants of rs6773957 have an association with OSAS in overweight individuals. In addition, polymorphisms of rs12495941, rs182052, and rs16861205 are associated with the severity of OSAS.

Combined Association Between ADIPOQ, PPARG, and TNF Genes Variants and Obstructive Sleep Apnea in Chinese Han Population

“…[18][19][20] Common variations in the ADIPOQ gene were linked to an increased risk and severity of OSA. 21 The ADIPOQ gene encodes the hormone adiponectin, and its levels correlate negatively with BMI. 22,23 TNF-α gene expression levels were significantly higher in the OSA group than in the control group.…”

Targeted sequencing analysis of the adiponectin gene identifies variants associated with obstructive sleep apnoea in Chinese Han population

“…Previous studies reported that ADIPOQ SNPs were not directly associated with an increased risk of OSA in the Chinese Han population. [12,13] However, they just research limited SNPs of ADIPOQ . In our study, we used targeted sequencing analysis to analyze entire ADIPOQ gene.…”

“…[11] Cao et al [12] observed a marked increase in the duration of the longest apnoea event in patients with the rs1501299 GG genotype than in those with GT/TT genotypes; another study found that the allele or genotype distributions of ADIPOQ rs12495941, rs182052, and rs16861205 were related to the severity of OSA. [13] However, both of the two researchers found no ADIPOQ SNP association with the occurrence of OSA in Chinese Han. As these two studies only detected part of the ADIPOQ locus.…”

Effects of different obesity-related adipokines on the occurrence of obstructive sleep apnea

“…The relationship between APN gene polymorphisms and OSA has become a hot topic in research. Wu et al found that the allele or genotype distributions of rs12495941, rs182052, and rs16861205 showed significant differences relative to OSA severity [72]. In addition, Yang et al identified four ADIPOQ variants, rs4686803, rs3774262, rs1063537, and rs2082940, associated with OSA prevalence in a Chinese han population after adjusting for confounding effects, among which CT/TT genotypes of rs4686803, GA/AA genotypes of rs3774262, and CT/TT genotypes of rs1063537 were associated with an increased risk of OSA, and the rs2082940 CC genotype was associated with a decreased risk of OSA [73].…”