Single nucleotide polymorphisms of ADRB2 gene and their association with susceptibility for Plasmodium falciparum malaria and asthma in an Indian population

Saadi, Abdul Vahab; Gupta, Himanshu; Angural, Arshia; Dhanya, Sreeja Kumari; Mony, Sridevi; Oberoi, Devesh; D’Souza, Sydney C.; Sahoo, Ramesh Chandra; Hande, Manjunath; Gopinath, P. M.; Satyamoorthy, Kapaettu

doi:10.1016/j.meegid.2013.08.026

Cited by 18 publications

(10 citation statements)

References 30 publications

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“…Therefore, compared with the G allele alone or the C allele alone, haplotype III could better predict the risk of asthma. These results are similar to the findings of Saadi et al . However, in their study on a Han population with asthma in southern China, Fu et al .…”

Section: Discussionsupporting

confidence: 91%

ADRB2 polymorphisms in allergic asthma in Han Chinese children

Tian

Liang

Qin

et al. 2015

Int Forum Allergy Rhinol

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Section: Discussionsupporting

confidence: 91%

ADRB2 polymorphisms in allergic asthma in Han Chinese children

Tian

Liang

Qin

et al. 2015

Int Forum Allergy Rhinol

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“…Therefore,we used Galbraith plots to graphically evaluate the source of heterogeneity. As showed in Figure 2A, four studies [31], [35], [47], [50] may be the main contributor to the heterogeneity in Asian population subgroup, and Figure 2B indicated that one study [15] maybe the main contributors to the heterogeneity in Caucasian population subgroup. In order to assess the reliablity of our meta-analysis, we further performed a sensitivity analysis through sequentially excluded individual study and similar result was obtained.…”

Section: Resultsmentioning

confidence: 99%

Association between β2-Adrenoceptor Gene Polymorphisms and Asthma Risk: An Updated Meta-Analysis

et al. 2014

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BackgroundEvidence is increasingly accumulated about multiple roles for the β2-adrenoceptor gene in asthma. The results were inconsistent partly due to small sample sizes. To assess the association between β2-adrenoceptor gene polymorphisms and asthma risk, a meta-analysis was performed.MethodsWe comprehensively searched the PubMed, EMBASE, BIOSIS Previews databases and extracted data from all eligible articles to estimate the association between β2-adrenoceptor gene polymorphisms and asthma risk. The pooled odds ratio (OR) with 95% confidence intervals (CIs) were calculated.ResultsThirty-seven studies involving 6648 asthma patients and 15943 controls were included in the meta-analysis. Overall, significant associations were found in allelic genetic model (OR = 1.06, 95% CI = 1.01∼1.12), recessive genetic model (OR = 1.11, 95% CI = 1.02∼1.21) for Arg/Gly16. Stratified by ethnicity and age, significant associations were also found in Asian population in allelic genetic model, recessive genetic model and addictive model. For Gln/Glu27, no significant association was found when we combined all eligible studies. Age stratification showed significant associations in adults in allelic genetic model and recessive genetic model, but no significant association was found among Asians and Caucasians in ethnicity stratification.ConclusionsThis meta-analysis implied that the β2-adrenoceptor Arg/Gly16 polymorphism was likely to contribute to asthma risk in Asian population. Gln/Glu27 polymorphism might be a contributor to asthma susceptibility for adults.

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“…GPCR signaling may be the underlying factor for a rapid and dynamic reorganization of sub-membranous cytoskeleton required for infection of the non-endocytic, mature erythrocyte by the pathogen. We have demonstrated in an earlier study, the association of GNAS and ADRB2 (member of GPCR family) genes with malaria disease at the genetic level Saadi et al, 2013). The G protein coupled adenosine A 2A receptor (ADORA2A) initiates signaling as a result of decrease or increase in intracellular cyclic AMP concentrations that inhibits or stimulates adenylyl cyclase (van Calker et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

“…It has also been reported that peptides disrupting the interaction of Gas and b2AR block erythrocyte invasion by Pf parasites in vitro (Harrison et al, 2003). Genetic screening of individuals for the factors affecting erythrocyte phase of infection Saadi et al, 2013;Fernandes et al, 2015) in endemic areas, may provide new insight into the possible mechanisms that may explain the varied susceptibility of individuals to malarial infection. Reports that are available suggest that adenosine receptors play a major role in cellular functions by coupling to G proteins, although several effects independent of G-proteins have also been reported (Fredholm et al, 2007).…”

Section: Introductionmentioning

confidence: 99%