Single Nucleotide Polymorphisms of Exon 1 and Exon 2 and Haplotypes of MBL Gene (MBL2) in Children with Repeated Respiratory Tract Infections in Chinese

Abstract

Background and aim: Mannose-binding lectin (MBL) is an important component of innate immunity. Eearlier studies have reported that low plasma MBL levels determined by the polymorphism of mbl 2 , were more common in children with recurrent infections. However, seldom study covered the haplotypes and exon2. In this study, we investigated the single nucleotide polymorphisms and haplotypes of promoter , exon1 and exon2 in children with repeated respiratory tract infections.