Single-nucleus RNA transcriptome profiling reveals murine adipose tissue endothelial cell proliferation gene networks involved in obesity development

Lu, Zhimin; Ding, Ling; Jiang, Xing; Zhang, Sen; Yan, Min; Yang, Guangxin; Tian, Xuewen; Wang, Qinglu

doi:10.1016/j.abb.2024.110029

Archives of Biochemistry and Biophysics

2024

DOI: 10.1016/j.abb.2024.110029

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Single-nucleus RNA transcriptome profiling reveals murine adipose tissue endothelial cell proliferation gene networks involved in obesity development

Zhimin Lu,

Ling Ding,

Xing Jiang

et al.

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2024

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Cited by 2 publications

References 71 publications

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Venous thrombosis and obesity: from clinical needs to therapeutic challenges

La Rosa,

Montecucco,

Liberale

et al. 2024

Intern Emerg Med

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Weight bias and stigma have limited the awareness of the systemic consequences related to obesity. As the narrative evolves, obesity is emerging as a driver and enhancer of many pathological conditions. Among these, the risk of venous thromboembolism (VTE) is a critical concern linked to obesity, ranking as the third most common cardiovascular condition. Obesity is recognized as a multifactorial risk factor for VTE, influenced by genetic, demographic, behavioral, and socio-economic conditions. Despite established links, the exact incidence of obesity related VTE in the general population remains largely unknown. The complexity of distinguishing between provoked and unprovoked VTE, coupled with gaps in obesity definition and assessment still complicates a tailored risk assessment of VTE risk. Obesity reactivity, hypercoagulability, and endothelial dysfunction are driven by the so-called ‘adiposopathy’. This state of chronic inflammation and metabolic disturbance amplifies thrombin generation and alters endothelial function, promoting a pro-thrombotic environment. Additionally, the inflammation-induced clot formation—also referred to as ‘immunothrombosis’ further exacerbates VTE risk in people living with obesity. Furthermore, current evidence highlights significant gaps in the management of obesity related VTE, particularly concerning prophylaxis and treatment efficacy of anticoagulants in people living with obesity. This review underscores the need for tailored therapeutic approaches and well-designed clinical trials to address the unique challenges posed by obesity in VTE prevention and management. Advanced research and innovative strategies are imperative to improve outcomes and reduce the burden of VTE in people living with obesity.

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Venous thrombosis and obesity: from clinical needs to therapeutic challenges

La Rosa,

Montecucco,

Liberale

et al. 2024

Intern Emerg Med

View full text Add to dashboard Cite

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Obesity-derived macrophages upregulate TNF-α to induce apoptosis in glial cell via the NF-κB/PHLPP1 axis

Ding,

Lu,

Jiang

et al. 2024

International Immunopharmacology

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Single-nucleus RNA transcriptome profiling reveals murine adipose tissue endothelial cell proliferation gene networks involved in obesity development

Cited by 2 publications

References 71 publications

Venous thrombosis and obesity: from clinical needs to therapeutic challenges

Venous thrombosis and obesity: from clinical needs to therapeutic challenges

Obesity-derived macrophages upregulate TNF-α to induce apoptosis in glial cell via the NF-κB/PHLPP1 axis

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