Single photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging for radiotherapy planning in patients with lung cancer: a meta-analysis

Lee, Soo Jin; Park, Hae Jin

doi:10.1038/s41598-020-71445-5

Cited by 21 publications

(10 citation statements)

References 35 publications

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“…This is somewhat countered by the higher concentration that may be achieved in tiny clusters of cells as compared to large, quantifiable tumours. Different techniques can be used to obtain data on the distribution of radiopharmaceuticals in a patient, which include single-photon emission computed tomography (SPECT) and positron emission tomography (PET) [ 92 ], as well as whole-body emission counting [ 93 ] and planar γ-imaging [ 94 ]. Several dosimetry methods have been methodically and rigorously researched and developed.…”

Section: Radiopharmaceuticals With Radiolabelled Peptides Towards Can...mentioning

confidence: 99%

Advances in Radionuclides and Radiolabelled Peptides for Cancer Therapeutics

Chakraborty

Mondal

et al. 2023

Pharmaceutics

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Radiopharmaceutical therapy, which can detect and treat tumours simultaneously, was introduced more than 80 years ago, and it has changed medical strategies with respect to cancer. Many radioactive radionuclides have been developed, and functional, molecularly modified radiolabelled peptides have been used to produce biomolecules and therapeutics that are vastly utilised in the field of radio medicine. Since the 1990s, they have smoothly transitioned into clinical application, and as of today, a wide variety of radiolabelled radionuclide derivatives have been examined and evaluated in various studies. Advanced technologies, such as conjugation of functional peptides or incorporation of radionuclides into chelating ligands, have been developed for advanced radiopharmaceutical cancer therapy. New radiolabelled conjugates for targeted radiotherapy have been designed to deliver radiation directly to cancer cells with improved specificity and minimal damage to the surrounding normal tissue. The development of new theragnostic radionuclides, which can be used for both imaging and therapy purposes, allows for more precise targeting and monitoring of the treatment response. The increased use of peptide receptor radionuclide therapy (PRRT) is also important in the targeting of specific receptors which are overexpressed in cancer cells. In this review, we provide insights into the development of radionuclides and functional radiolabelled peptides, give a brief background, and describe their transition into clinical application.

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Section: Radiopharmaceuticals With Radiolabelled Peptides Towards Can...mentioning

confidence: 99%

Advances in Radionuclides and Radiolabelled Peptides for Cancer Therapeutics

Chakraborty

Mondal

et al. 2023

Pharmaceutics

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“…However, these parameters are evaluated across the whole lung volume and do not account for functional differences between lung regions. Recently, regional lung functionality assessment has been shown to enable highly functional lung areas to be spared from irradiation and thus can be used to design treatment plans that reduce the risk of injury ( Hoover et al, 2014 ; Bucknell et al, 2018 ; Lee and Park, 2020 ; Vinogradskiy et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

A super-voxel-based method for generating surrogate lung ventilation images from CT

et al. 2023

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Purpose: This study aimed to develop and evaluate CTVISVD, a super-voxel-based method for surrogate computed tomography ventilation imaging (CTVI).Methods and Materials: The study used four-dimensional CT (4DCT) and single-photon emission computed tomography (SPECT) images and corresponding lung masks from 21 patients with lung cancer obtained from the Ventilation And Medical Pulmonary Image Registration Evaluation dataset. The lung volume of the exhale CT for each patient was segmented into hundreds of super-voxels using the Simple Linear Iterative Clustering (SLIC) method. These super-voxel segments were applied to the CT and SPECT images to calculate the mean density values (Dmean) and mean ventilation values (Ventmean), respectively. The final CT-derived ventilation images were generated by interpolation from the Dmean values to yield CTVISVD. For the performance evaluation, the voxel- and region-wise differences between CTVISVD and SPECT were compared using Spearman’s correlation and the Dice similarity coefficient index. Additionally, images were generated using two deformable image registration (DIR)-based methods, CTVIHU and CTVIJac, and compared with the SPECT images.Results: The correlation between the Dmean and Ventmean of the super-voxel was 0.59 ± 0.09, representing a moderate-to-high correlation at the super-voxel level. In the voxel-wise evaluation, the CTVISVD method achieved a stronger average correlation (0.62 ± 0.10) with SPECT, which was significantly better than the correlations achieved with the CTVIHU (0.33 ± 0.14, p < 0.05) and CTVIJac (0.23 ± 0.11, p < 0.05) methods. For the region-wise evaluation, the Dice similarity coefficient of the high functional region for CTVISVD (0.63 ± 0.07) was significantly higher than the corresponding values for the CTVIHU (0.43 ± 0.08, p < 0.05) and CTVIJac (0.42 ± 0.05, p < 0.05) methods.Conclusion: The strong correlation between CTVISVD and SPECT demonstrates the potential usefulness of this novel method of ventilation estimation for surrogate ventilation imaging.

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“…The field of functional imaging of the lung is underrapid development in recent years. Single-photon emission computed tomography (SPECT) imaging is traditionally used to provide functional information of the lung including ventilation using technetium-99 mor xenon-133 and perfusion using technetium-99 m. 10 Early work by Marks et al 11 demonstrated that pulmonary perfusion indicated by SPECT showed unique values in "designing radiation portals to minimize irradiation of functioning lung". More interestingly, pulmonary perfusion was noticed to decline in 1-6 months in areas receiving 40 Gy of dose.…”

Section: Introductionmentioning

confidence: 99%

A pilot study of function‐based radiation therapy planning for lung cancer using hyperpolarized xenon‐129 ventilation MRI

Ding

Yang

Zhou

et al. 2022

J Applied Clin Med Phys

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Purpose Radiation‐induced lung injury (RILI) is a common side effect in patients with non‐small cell lung cancer (NSCLC) treated with radiotherapy. Minimizing irradiation into highly functional areas of the lung may reduce the occurrence of RILI. The aim of this study is to evaluate the feasibility and utility of hyperpolarized xenon‐129 magnetic resonance imaging (MRI), an imaging tool for evaluation of the pulmonary function, to guide radiotherapy planning. Methods Ten locally advanced NSCLC patients were recruited. Each patient underwent a simulation computed tomography (CT) scan and hyperpolarized xenon‐129 MRI, then received 64 Gyin 32 fractions for radiotherapy. Clinical contours were drawn on CT. Lung regions with good ventilation were contoured based on the MRI. Two intensity‐modulated radiation therapy plans were made for each patient: an anatomic plan (Plan‐A) based on CT alone and a function‐based plan (Plan‐F) based on CT and MRI results. Compared to Plan‐A, Plan‐F was generated with two additional steps: (1) beam angles were carefully chosen to minimize direct radiation entering well‐ventilated areas, and (2) additional optimization criteria were applied to well‐ventilated areas to minimize dose exposure. V20Gy, V10Gy, V5Gy, and the mean dose in the lung were compared between the two plans. Results Plan‐A and Plan‐F were both clinically acceptable and met similar target coverage and organ‐at‐risk constraints (p > 0.05) except for the ventilated lungs. Compared with Plan‐A, V5Gy (Plan‐A: 30.7 ± 11.0%, Plan‐F: 27.2 ± 9.3%), V10Gy (Plan‐A: 22.0 ± 8.6%, Plan‐F: 19.3 ± 7.0%), and V20Gy (Plan‐A: 12.5 ± 5.6%, Plan‐F: 11.0 ± 4.1%) for well‐ventilated lung areas were significantly reduced in Plan‐F (p < 0.05). Conclusion In this pilot study, function‐based radiotherapy planning using hyperpolarized xenon‐129 MRI is demonstrated to be feasible in 10 patients with NSCLC with the potential to reduce radiation exposure in well‐ventilated areas of the lung defined by hyperpolarized xenon‐129 MRI.

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Single photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging for radiotherapy planning in patients with lung cancer: a meta-analysis

Cited by 21 publications

References 35 publications

Advances in Radionuclides and Radiolabelled Peptides for Cancer Therapeutics

Advances in Radionuclides and Radiolabelled Peptides for Cancer Therapeutics

A super-voxel-based method for generating surrogate lung ventilation images from CT

A pilot study of function‐based radiation therapy planning for lung cancer using hyperpolarized xenon‐129 ventilation MRI

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