Single-photon emission computed tomography in neurotherapeutics

Devous, Michael D.

doi:10.1602/neurorx.2.2.237

Cited by 34 publications

(6 citation statements)

References 54 publications

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“…[13] It is not indicated in most of the patients with epilepsy but has an important role in presurgical evaluation of refractory epilepsy patients. The use of SPECT in epilepsy stems from the known association of seizures with increased ictal regional cerebral perfusion or interictal decrease in perfusion.…”

Section: Imaging Modalitiesmentioning

confidence: 99%

“…Single photon emission computerized tomography (SPECT) is a nuclear medicine imaging method that allows for the quantitative and qualitative evaluation of regional cerebral perfusion. [ 13 ] It is not indicated in most of the patients with epilepsy but has an important role in presurgical evaluation of refractory epilepsy patients. The use of SPECT in epilepsy stems from the known association of seizures with increased ictal regional cerebral perfusion or interictal decrease in perfusion.…”

Section: Imaging Modalitiesmentioning

confidence: 99%

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Neuroimaging in epilepsy

Roy

Pandit

2011

Ann Indian Acad Neurol

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Epilepsy is a common neurological disorder with diverse etiologies. Neuroimaging plays an important role in workup of patients with epilepsy. It helps to identify brain pathologies that require specific treatment; and also in formulating syndromic and etiological diagnoses so as to give patients and their relatives an accurate prognosis. Magnetic resonance imaging, specially the 3 tesla MRI is the imaging of choice because of its ability to detect small lesions like mesial temporal sclerosis, cortical dysplasias, small tumors, etc that are not detected by conventional MR or CT scan of brain. Identification of these lesions often helps in managing refractory epilepsies more effectively. However, cost and non-availability of MR in large part of the country necessitate the use of CT as an alternative. CT is often the initial investigation and also useful in acute situations. Functional imagings are used for pre-surgical work-up of refractory epilepsy cases with an aim to identify the epileptogenic focus and to delineate functional areas nearing the focus.

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Section: Imaging Modalitiesmentioning

confidence: 99%

Section: Imaging Modalitiesmentioning

confidence: 99%

Neuroimaging in epilepsy

Roy

Pandit

2011

Ann Indian Acad Neurol

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“…There are numerous publications proving SPECT functional brain imaging as a powerful research tool, especially in the fields of cerebrovascular disease and cognitive disorders, and there is extensive development in receptor and molecular imaging ( 91 ). In a recent systematic review, Raji et al concluded that SPECT imaging could be useful in evaluating patients with neurological and psychiatrically sequela after TBI ( 92 ).…”

Section: Positron Emission Tomographymentioning

confidence: 99%

Imaging of Cerebral Blood Flow in Patients with Severe Traumatic Brain Injury in the Neurointensive Care

2014

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Ischemia is a common and deleterious secondary injury following traumatic brain injury (TBI). A great challenge for the treatment of TBI patients in the neurointensive care unit (NICU) is to detect early signs of ischemia in order to prevent further advancement and deterioration of the brain tissue. Today, several imaging techniques are available to monitor cerebral blood flow (CBF) in the injured brain such as positron emission tomography (PET), single-photon emission computed tomography, xenon computed tomography (Xenon-CT), perfusion-weighted magnetic resonance imaging (MRI), and CT perfusion scan. An ideal imaging technique would enable continuous non-invasive measurement of blood flow and metabolism across the whole brain. Unfortunately, no current imaging method meets all these criteria. These techniques offer snapshots of the CBF. MRI may also provide some information about the metabolic state of the brain. PET provides images with high resolution and quantitative measurements of CBF and metabolism; however, it is a complex and costly method limited to few TBI centers. All of these methods except mobile Xenon-CT require transfer of TBI patients to the radiological department. Mobile Xenon-CT emerges as a feasible technique to monitor CBF in the NICU, with lower risk of adverse effects. Promising results have been demonstrated with Xenon-CT in predicting outcome in TBI patients. This review covers available imaging methods used to monitor CBF in patients with severe TBI.

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“…Radiopharmaceuticals that bind to apoptotic cells (e.g., 99m Tc-Annexin) have been used preclinically to validate the possible toxicity effects in developing therapies [ 97 ]. Other examples on secondary response to the administration of a candidate drug in preclinical models include measurements in blood flow changes [ 98 ] and infiltration of inflammatory cells [ 99 ].…”

Section: Spect In Preclinical Applicationsmentioning

confidence: 99%

Molecular SPECT Imaging: An Overview

Khalil

Tremoleda

Bayomy

et al. 2011

International Journal of Molecular Imaging

224

138

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Molecular imaging has witnessed a tremendous change over the last decade. Growing interest and emphasis are placed on this specialized technology represented by developing new scanners, pharmaceutical drugs, diagnostic agents, new therapeutic regimens, and ultimately, significant improvement of patient health care. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) have their signature on paving the way to molecular diagnostics and personalized medicine. The former will be the topic of the current paper where the authors address the current position of the molecular SPECT imaging among other imaging techniques, describing strengths and weaknesses, differences between SPECT and PET, and focusing on different SPECT designs and detection systems. Radiopharmaceutical compounds of clinical as well-preclinical interest have also been reviewed. Moreover, the last section covers several application, of μSPECT imaging in many areas of disease detection and diagnosis.

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Single-photon emission computed tomography in neurotherapeutics

Cited by 34 publications

References 54 publications

Neuroimaging in epilepsy

Neuroimaging in epilepsy

Imaging of Cerebral Blood Flow in Patients with Severe Traumatic Brain Injury in the Neurointensive Care

Molecular SPECT Imaging: An Overview

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