Single polydiacetylene microtube waveguide platform for discriminating microRNA-215 expression levels in clinical gastric cancerous, paracancerous and normal tissues

Wang, Mengqiao; Yu, Yue; Liu, Funing; Ren, Le; Zhang, Qijin; Zou, Gang

doi:10.1016/j.talanta.2018.05.049

Cited by 19 publications

(8 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TNP captured on the waveguide could be removed by washing with ethanol, thus ensuring the reversibility of the waveguide (Figure 17aii). In addition, the amine groups stretching out on the microtubes can be tailor-made to be sensitive to other analytes, such as miRNA-21, 289 miRNA-215, 290 light, 291 and polarized light. 292 In another report, Oh et al presented a novel meniscusguided method to fabricate free-standing PDA microtubes.…”

Section: Chemistry Of Materialsmentioning

confidence: 99%

Recent Developments in Polydiacetylene-Based Sensors

2019

View full text Add to dashboard Cite

Conjugated polymers are intriguing materials that have potential practical applications in diverse interdisciplinary subjects. Among them, polydiacetylenes (PDAs) have been extensively studied due to their interesting structural, spectral, and optical features. In particular, the unique colorimetric and fluorescent transition of PDAs in response to different external stimuli makes them a novel class of sensing materials, and numerous applications of PDAs as bio-or chemosensors have been explored in the past few decades. In this review, we summarize the latest developments with regard to the applications of PDAs as a class of sensing materials presented in the literature since 2014. This review is sorted into categories based on the structural differences of diacetylene monomers, from which PDAs are generated. In addition, different forms of PDAs and various methods for improving the sensing performance of PDAs are also emphasized.

show abstract

Section: Chemistry Of Materialsmentioning

confidence: 99%

Recent Developments in Polydiacetylene-Based Sensors

2019

View full text Add to dashboard Cite

show abstract

“…Chemicals that are valuable for the diagnosis of gastric cancer, such as miRNA-215 [59], are also often expressed at higher levels in paracancerous tissue than in normal tissue [60], indicating the significance of adjacent tissues for the diagnosis of gastric cancer. This suggests that it is not sufficient that only specific tumor areas for the networks are conserved.…”

Section: Ic Modulementioning

confidence: 99%

A Hierarchical Conditional Random Field-based Attention Mechanism Approach for Gastric Histopathology Image Classification

Li¹,

Wu²,

Li³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Zou et al employed a similar hybridization sensing mechanism for the detection of miRNA-215 but with a different designing strategy. [37] They synthesized a PDA microtube waveguide system that exhibited strong fluorescence. The target miRNA was captured by two oligonucleotides that were conjugated to the microtube and Au nanorod, respectively, forming a sandwich-type hybrid complex.…”

Section: (6 Of 12)mentioning

confidence: 99%

Section: (6 Of 12)mentioning

confidence: 99%

Polydiacetylene‐Based Biosensors for the Detection of Viruses and Related Biomolecules

Qian

Städler

2020

Adv Funct Materials

View full text Add to dashboard Cite

Viruses are a major threat to the wellbeing of humans, animals, and plants. The current diagnostics of viral RNA/DNA are largely dependent on polymerase chain reaction (PCR) and related concepts. Serological and immunological assays on the other hand aim to identify the presence of antibodies. Alternative approaches that consider non-biological entities as part of the sensing setup might be a complementary path to alleviate the pressure on access to high-quality biomolecules and PCR reagents. In this context, polydiacetylenes are widely explored as biosensors because these polymers can be synthesized in situ only with the assistance of light in the desired environment. In addition, this unique group of polymers can be utilized as biosensors to detect an assortment of biomolecules and pathogens with dual optical outputs. The detection of viruses and related biomolecules with polydiacetylenes have been explored over the course of the past three decades. This progress report aims to provide a comprehensive summary of polydiacetylene-based biosensors for the detection of viruses and also related biomolecules, including nucleic acids and proteins. Given the current situation, this progress report will hopefully inspire scientists and contribute to the development of novel biosensors for the fast and effective detection of viruses.

show abstract

Single polydiacetylene microtube waveguide platform for discriminating microRNA-215 expression levels in clinical gastric cancerous, paracancerous and normal tissues

Cited by 19 publications

References 48 publications

Recent Developments in Polydiacetylene-Based Sensors

Recent Developments in Polydiacetylene-Based Sensors

A Hierarchical Conditional Random Field-based Attention Mechanism Approach for Gastric Histopathology Image Classification

Polydiacetylene‐Based Biosensors for the Detection of Viruses and Related Biomolecules

Contact Info

Product

Resources

About