Single-run ultra-high performance liquid chromatography for quantitative determination of ultra-traces of ten popular active pharmaceutical ingredients by quadrupole time-of-flight mass spectrometry after offline preconcentration by solid phase extraction from drinking and river waters as well as treated wastewater

Krakkó, Dániel; Licul-Kucera, Viktória; Záray, Gyula; Mihucz, Victor G.

doi:10.1016/j.microc.2019.04.047

Cited by 41 publications

(14 citation statements)

References 44 publications

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“…As for the other two analgesics/anti-inflamatories, DCF and TA concern, their detected concentrations were only at levels < LOQ. ΤΑ is excreted unchanged in 8.8%, therefore, low concentrations might enter the influent, while for DCF excretion rates vary from <1 to 90% ( Krakkó et al, 2019 ). Similar results for the concentration levels of SA in hospital wastewaters have been observed in the literature ( Kosma et al, 2014 ; Verlicchi et al, 2012 ), while for DCF and TA similar and/or higher concentrations have been found ( Couto et al, 2019 ; Paíga et al, 2019 ; Verlicchi et al, 2012 ).…”

Section: Resultsmentioning

confidence: 99%

“…The main source of pharmaceutical pollution is highly associated with urban and hospital Wastewater Treatment Plant (WWTP) effluents ( Krakkó et al, 2019 ). Due to the numerous care activities performed in hospitals, hospital wastewater (HWW) constitutes a complex matrix with high loads of PhACs and metabolites, disinfectants, heavy metals, reagents etc.…”

Section: Introductionmentioning

confidence: 99%

“…Conventional WWTP technologies are not designed and constructed to efficient remove PhACs at trace levels and therefore, treated effluents still contain pharmaceuticals in considerable concentrations. In most of the cases, PhACs are not metabolized in a great extent in the human body and conclude in unchanged form in the sewage systems ( Krakkó et al, 2019 ). Depending on the compound, excretion rate from the human body as well as removal from WWTPs, can vary from 0.04 to 100% and from 0 to 100%, respectively ( Fekadu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, in Europe, compounds such as diclofenac, ibuprofen, triclosan, sulfadimidine, carbamazepine and fluoxetine were reported in concentrations higher than the available ecotoxicity endpoints ( Fekadu et al, 2019 ). Being aware of the fact that information about the long-term and low-level exposure of PhACs is limited, potential threat to the aquatic environment and to humans is probable ( Konstas et al, 2019 ; Krakkó et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment

Kosma

Kapsi

Konstas

et al. 2020

Environmental Research

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Nowadays the occurrence and associated risks of Pharmaceutical Active Compounds (PhACs) in the aquatic environment comprises a major issue. In the present study, a comprehensive survey on contamination profiles, occurrence, removals, temporal variation and ecological risk of multiclass multiresidue PhACs, such as antibiotics, non-steroidal anti-inflammatories, lipid regulators and phsychiatrics, (including past and newly monitored PhACs as well as some of their metabolites) was performed in wastewaters from the WWTP of Ioannina University hospital along one year period on a monthly sampling basis. WWTP influent and effluent samples were analyzed for physicochemical quality parameters and PhACs concentration levels using Ultra High Performance Liquid Chromatography-Orbitrap-Mass Spectrometry (UHPLC-Orbitrap-MS), after Solid Phase Extraction (SPE) through Oasis HLB cartridges. Influent concentrations ranged between < LOQ (Limit of Quantification) for diclofenac and tolfenamic acid and 48586 ng/L for caffeine, while effluent concentrations between < LOQ for tolfenamic acid and simvastatin and 3361 ng/L for caffeine. Removal efficiencies ranged between −132.6% for venlafaxine and 100% for caffeine. Environmental risk assessment by means of Risk Quotient (RQ) for maximum and minimum concentration levels as well as optimized by the frequency of exceeding toxicity threshold values, RQ f , was applied revealing that up to 12 PhACs posed acute toxicity (clofibric acid, fenofibrate, sulfadiazine, sulfamethoxazole, trimethoprim, amitryptiline, fluoxetine, fluvoxamine, norfluoxetine, sertraline, venlafaxine, caffeine) while up to 4 compounds exerted long-term toxicity (sulfamethoxazole, fluoxetine, sertraline, caffeine) at least for one of the studied organisms. Furthermore, mixture RQ MEC/PNEC and RQ STU effect of multiple compounds showed high potential risks of the target groups in some cases, although some contaminants were not included due to lack of available data. Results can be used to prioritization of PhACs and their metabolites for surveillance in receiving water bodies as well as development of knowledge on toxicity and mechanism(s) of action.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment

Kosma

Kapsi

Konstas

et al. 2020

Environmental Research

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“…Studies have reported low recovery values of 23.25–48.11% for some of the pesticides analyzed using the SPE method by Badawy et al [ 101 ]. Likewise, low recovery values of 40–80% were reported for extracting pharmaceuticals using SPE approach [ 142 ]. In literature, effective recovery of emerging pollutants using MSPE method has been reported.…”

Section: Extraction Of Mycotoxins Pesticides and Pharmaceuticalsmentioning

confidence: 99%

Current Applications of Magnetic Nanomaterials for Extraction of Mycotoxins, Pesticides, and Pharmaceuticals in Food Commodities

2021

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Environmental pollutants, such as mycotoxins, pesticides, and pharmaceuticals, are a group of contaminates that occur naturally, while others are produced from anthropogenic sources. With increased research on the adverse ecological and human health effects of these pollutants, there is an increasing need to regularly monitor their levels in food and the environment in order to ensure food safety and public health. The application of magnetic nanomaterials in the analyses of these pollutants could be promising and offers numerous advantages relative to conventional techniques. Due to their ability for the selective adsorption, and ease of separation as a result of magnetic susceptibility, surface modification, stability, cost-effectiveness, availability, and biodegradability, these unique magnetic nanomaterials exhibit great achievement in the improvement of the extraction of different analytes in food. On the other hand, conventional methods involve longer extraction procedures and utilize large quantities of environmentally unfriendly organic solvents. This review centers its attention on current applications of magnetic nanomaterials and their modifications in the extraction of pollutants in food commodities.

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Detection methods for antibiotics in wastewater: a review

Luo,

Sun,

Wei

et al. 2024

Bioprocess Biosyst Eng

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Cited by 41 publications

References 44 publications

Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment

Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment

Current Applications of Magnetic Nanomaterials for Extraction of Mycotoxins, Pesticides, and Pharmaceuticals in Food Commodities

Detection methods for antibiotics in wastewater: a review

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