Abstract:Identifying probe-modified peptides in chemical proteomics experiments is challenging due to the production of only one modified peptide per probe reaction at a specific site on a protein and the possibility of inconclusive proteomic identification. To address these issues, we propose a principle of Single-Sequence Identification (SSI) and a method for identifying probe-modified peptides in chemical proteomics experiments. The new approach creates multiple versions of the modified peptide in the proteomic iden… Show more
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