Single Session Facial Lipostructure by Using Autologous Fat Mixed With Platelet-Rich Fibrin Injected by Using Facial Autologous Muscular Injection Technique

Al-Chalabi, Najwa Jamil Abdulrazzak; Al-Quisi, Ahmed Fadhel; Lateef, Thair Abdul

doi:10.1097/scs.0000000000004307

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…After title and abstract screening, 95 studies remained for full-text assessment of eligibility criteria ( Figure 1 ). A total of 27 studies were included; 68 studies were excluded for the following reasons: 10 studies were excluded because the fat graft was not supplemented; 23 , 31-39 19 studies were excluded because fat graft retention was not assessed by volumetric or patient satisfaction measurements; 40-59 3 studies were excluded because the study methods or intervention were not evaluable due to insufficient description; 60-62 8 studies were excluded because these were conference abstracts; 63-69 13 studies were excluded because these concerned trial registrations; 70-82 1 study was excluded because the supplementation therapy was not carried out in the face, but in other body parts; 83 in 1 study the injection site was not adipose tissue but product was injected within the muscles of the face (facial muscular plane); 84 12 studies were excluded because they did not describe human subjects or clinical results; 85-95 no translation of 1 study was available (Russian). 96 …”

Section: Resultsmentioning

confidence: 99%

Supplementation of Facial Fat Grafting to Increase Volume Retention: A Systematic Review

Schipper

Vriend

Tuin

et al. 2022

Aesthetic Surgery Journal

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Background For decades, facial fat grafting is used in clinical practice for volume restoration. The main challenge of this technique is the variable volume retention. Over the past years, studies reported the addition of supplements to augment the fat graft to increase volume retention. Objectives The aim of this systematic review was to investigate which supplements increase volume retention in facial fat grafting as assessed with volumetric outcomes and patient satisfaction. Methods Central, MEDLINE, EMBASE, Web of Science Core Collection and Google Scholar were searched until 30th of November 2020. Only studies assessing volume after facial fat grafting with supplementation in human subjects were included. Outcomes of interest were volume or patient satisfaction. Quality of the studies was assessed using the Effective Public Health Practice Project tool. Results After duplicates were removed 3724 studies were screened by title and abstract. After reading 95 full-text articles, 27 studies were eligible and included for comparison. Supplementation comprised of platelet rich plasma (PRP), platelet rich fibrin, adipose tissue-derived stromal cells or bone marrow-derived stromal cells, cellular or tissue stromal vascular fraction (SVF) or nanofat. In 13 out of 22 studies the supplemented group showed improved volumetric retention and 5 out of 16 studies showed greater satisfaction. The scientific quality of the studies was rated as weak for 20 of 27 studies, moderate for 6 of 27 studies and strong for 1 study. Conclusions Our results show that it remains unclear if additives contribute to facial fat graft retention while there is a need to standardize methodology.

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Section: Resultsmentioning

confidence: 99%

Supplementation of Facial Fat Grafting to Increase Volume Retention: A Systematic Review

Schipper

Vriend

Tuin

et al. 2022

Aesthetic Surgery Journal

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“…Previous studies have shown that PRF can significantly improve vascularization of transplanted adipose tissue, thus increasing survival 12–15 . However, relatively few studies have investigated the effect of CGF on the survival of adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that PRF can significantly improve vascularization of transplanted adipose tissue, thus increasing survival. [12][13][14][15]…”

Section: Discussionmentioning

confidence: 99%

Study on the Application of Concentrated Growth Factor Combined With Adipose Transplantation in Repairing Depressed Deformities of Soft Tissue in the Face

Li,

Yang,

Lou

et al. 2023

Ann Plast Surg

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Background Autologous fat is a rich source of adipose tissue that is safe for transplantation. Decreasing the long-term absorption rate is key to improve the survival of transplanted adipose tissue. The aim of this study was to assess the effect of concentrated growth factor (CGF) on the survival of transplanted adipose tissue for repair of facial depression malformations. Methods Coleman adipose granules (CAGs) were prepared from venous blood. In the animal experiment, the ears of 30 healthy male New Zealand white rabbits were randomly allocated to 1 of 4 groups: CGF + CAG (CGF group), platelet-rich fibrin (PRF) + CAG (PRF group), CAG alone (CAG group), and adipose granule transplantation group (control group). Postoperative survival of the transplanted adipose tissue was assessed, the survival and absorption rates of adipose were calculated, and immunohistochemical analysis of specimens was conducted by staining with hematoxylin and eosin and Oil Red O. Of 43 outpatients, 22 received simple adipose transplantation and 21 received autologous CGF combined with adipose transplantation. The adipose absorption rate, complication rate, and cosmetic improvement of the 2 groups were compared. Results More adipocytes that are normal were observed in the CGF group, with fewer vacuoles and more uniform distribution of adipose tissue. Survival of the adipose tissue was superior in the CGF and PRF groups. Meanwhile, vascular density and long-term stability were better in the CGF group than the PRF group. In terms of clinical efficacy, the uniformity and survival rate of the adipose tissue were relatively improved in the CGF group compared with the simple adipose particle transplantation group, with less early liquefaction. Conclusion Concentrated growth factor stabilized and improved the survival of transplanted adipose tissue for filling of facial depression malformations.

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“…The first research on autologous adipose tissue graft was published in the early 20th century; fat grafting provides the benefits of availability, ease of acquisition, favorable biocompatibility, and minimal surgical trauma 17 . The fat transplant was first used in soft tissue filling surgeries, such as defect repairs, deformity correction of deformities, and facial cosmetic procedures 17,18 …”

mentioning

confidence: 99%

“…17 The fat transplant was first used in soft tissue filling surgeries, such as defect repairs, deformity correction of deformities, and facial cosmetic procedures. 17,18 The nanofat grafting technique, introduced by Tonnard et al 19 in 2013, mechanically dissociated the emulsion of adipose tissue with the extracellular matrix, rich in nucleated cells and stem cells used as injections. 20 Intra-articular injections, considered minimally invasive clinical treatments, hold great opportunities for therapeutic roles in ID with the practical and undercontrolled delivery of drugs and stem cells, with less risk of systemic side effects.…”

mentioning

confidence: 99%

Can the Autogenous Nanofat Injection Improve the Symptoms of Patients With Temporomandibular Joint Internal Derangement? A Prospective Observational Clinical Study

Ali,

Hadi

2023

Journal of Craniofacial Surgery

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Since nanofat is considered one of the richest sources of adipose-derived stem cells with an increased need for new biological approaches for managing temporomandibular joint internal derangement (TMJ-ID) symptoms that impair a patient’s lifestyle, this study evaluated the effectiveness of autogenous nanofat intra-articular injection in managing ID symptoms regarding pain, mouth opening, and joint sound. Furthermore, to assess the consequences and complications of this procedure, 20 patients with 38 TMJs with varying stages of Wilkes classification were included in the study. All involved patients were previously diagnosed with ID depending on a clinical and radiographical basis and had no previous response to conservative management for at least 4 to 6 months. Evaluation of the ID in the preoperative phase, as well as 2 weeks, 1 month, 3 months, and 6 months postoperatively. An evaluation was done depending on pain assessment using a visual analog scale (VAS), measuring maximum mouth opening (MMO) and joint noise if it was present or absent preoperatively and postoperatively. The results show improvement in the symptoms in all follow-up appointments since the VAS of pain decreased significantly with increased MMO and the absence of clicking in most cases during follow-up appointments. We conclude from this study that nanofat intra-articular injection was influential in managing ID symptoms and was safe without significant side effects.

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Single Session Facial Lipostructure by Using Autologous Fat Mixed With Platelet-Rich Fibrin Injected by Using Facial Autologous Muscular Injection Technique

Abstract: Mixing fat with PRF and injecting them by using facial autologous muscular injection technique offers better graft survival by utilizing the growth factors and cytokines in PRF clot together with rich vascular plexus in the muscular layer consequently.

Cited by 6 publications

References 7 publications

Supplementation of Facial Fat Grafting to Increase Volume Retention: A Systematic Review

Supplementation of Facial Fat Grafting to Increase Volume Retention: A Systematic Review

Study on the Application of Concentrated Growth Factor Combined With Adipose Transplantation in Repairing Depressed Deformities of Soft Tissue in the Face

Can the Autogenous Nanofat Injection Improve the Symptoms of Patients With Temporomandibular Joint Internal Derangement? A Prospective Observational Clinical Study

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