Single-unit and slow potential responses from rat frontal cortex during associative conditioning

Pirch, James H.; Corbus, Mary Jo; Rigdon, Greg C.

doi:10.1016/0014-4886(83)90247-9

Cited by 24 publications

(4 citation statements)

References 27 publications

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“…This is not only a reasonable inference from earlier cited studies, but also a clear conclusion from many later ones (Pigarev et al, 1979;Suzuki et al, 1979;Kojima, 1980;Watanabe, 1981Watanabe, , 1986Pirch et al, 1983;Thorpe et al, 1983;Ono et al, 1984;Inoue et al, 1985;Yajeya et al, 1988;Sawaguchi et al, 1989;Yamatani et al, 1990;Sakagami and Niki, 1994). This is not only a reasonable inference from earlier cited studies, but also a clear conclusion from many later ones (Pigarev et al, 1979;Suzuki et al, 1979;Kojima, 1980;Watanabe, 1981Watanabe, , 1986Pirch et al, 1983;Thorpe et al, 1983;Ono et al, 1984;Inoue et al, 1985;Yajeya et al, 1988;Sawaguchi et al, 1989;Yamatani et al, 1990;Sakagami and Niki, 1994).…”

Section: The Memorandumsupporting

confidence: 68%

Neurophysiology

Fuster

2015

The Prefrontal Cortex

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Section: The Memorandumsupporting

confidence: 68%

Neurophysiology

Fuster

2015

The Prefrontal Cortex

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“…Victims of Alzheimer's disease exhibit decreases in the amplitude of the contingent negative variation, a conditioned slow negative wave recorded from the scalp in response to a cue followed by some meaningful event (Rizzo et al, 1984). Similar event-related slow potentials may be recorded from the rat frontal cortex using the same conditioning paradigm that elicits conditioned unit responses (Pirch et al, 1983(Pirch et al, ,1985a. The amplitudes of these slow potentials are decreased by (1) local blockade of cholinergic receptors, (2) electrolytic or neurotoxin lesioning of the nucleus basalis, and (3) microinjection of inhibitory compounds into the nucleus basalis (Pirch et al, 1984(Pirch et al, , 1986.…”

Section: Discussionmentioning

confidence: 99%

“…The single-unit responses develop with training and extinguish if the MFJ3 stimulation is discontinued. The cue and event must be paired for development of maximal responses (Pirch et al, 1983). When tested in a discrimination paradigm, 94% of the units that exhibited conditioned responses had sig-nificantly larger responses to the reinforced cue than to the nonreinforced cue (Rucker et al, 1985).…”

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confidence: 99%

Nucleus basalis involvement in conditioned neuronal responses in the rat frontal cortex

Rigdon¹,

Pirch²

1986

J. Neurosci.

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Rat frontal cortex neurons exhibit alterations in firing in response to a 2 sec tone cue followed by rewarding medial forebrain bundle (MFB) stimulation. Nucleus basalis neurons supply up to 75% of the cortical cholinergic innervation. The nucleus basalis and ACh have been implicated as playing a role in cognitive function. Three experiments were designed to test the hypothesis that the nucleus basalis cholinergic system is involved in the generation of conditioned neuronal responses in the rat frontal cortex. Local microinjection of the cholinergic antagonist, atropine, into the frontal cortex suppressed the conditioned responses of 22 of 25 cortical single units. Unilateral kainic acid lesioning of the nucleus basalis resulted in a significant decrease in the proportion of units exhibiting conditioned responses in the cortex ipsilateral to the lesion (25%) compared to the proportion of responding units from the cortex of untreated animals (70%). When the firing rates of units encountered in the region of the nucleus basalis were monitored during presentation of the cue-MFB paradigm, 28 of 38 unit recordings exhibited significant increases or decreases in firing rate. Therefore, the results of the experiments indicate that the nucleus basalis cholinergic neurons are involved in the generation of conditioned neuronal responses in the rat frontal cortex.

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“…The firing of mPFC cells has been known to exhibit reward-related modulation ( 31 , 35 – 38 ). To investigate the effect of reward on the spatial firing properties of mPFC border cells, we first calculated the heat maps of cumulative density of food pellets and found there was no significant accumulation of food near the periphery of the environment ( S I Appendix , Fig.…”

Section: Resultsmentioning

confidence: 99%

Border cells without theta rhythmicity in the medial prefrontal cortex

Long,

Deng,

Shen

et al. 2024

Proc. Natl. Acad. Sci. U.S.A.

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The medial prefrontal cortex (mPFC) is a key brain structure for higher cognitive functions such as decision-making and goal-directed behavior, many of which require awareness of spatial variables including one’s current position within the surrounding environment. Although previous studies have reported spatially tuned activities in mPFC during memory-related trajectory, the spatial tuning of mPFC network during freely foraging behavior remains elusive. Here, we reveal geometric border or border-proximal representations from the neural activity of mPFC ensembles during naturally exploring behavior, with both allocentric and egocentric boundary responses. Unlike most of classical border cells in the medial entorhinal cortex (MEC) discharging along a single wall, a large majority of border cells in mPFC fire particularly along four walls. mPFC border cells generate new firing fields to external insert, and remain stable under darkness, across distinct shapes, and in novel environments. In contrast to hippocampal theta entrainment during spatial working memory tasks, mPFC border cells rarely exhibited theta rhythmicity during spontaneous locomotion behavior. These findings reveal spatially modulated activity in mPFC, supporting local computation for cognitive functions involving spatial context and contributing to a broad spatial tuning property of cortical circuits.

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Single-unit and slow potential responses from rat frontal cortex during associative conditioning

Cited by 24 publications

References 27 publications

Neurophysiology

Neurophysiology

Nucleus basalis involvement in conditioned neuronal responses in the rat frontal cortex

Border cells without theta rhythmicity in the medial prefrontal cortex

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