Single-Use Instrumente in der endoskopischen Gastroenterologie

Schlicht, Henning; Wintermantel, E.

doi:10.1007/978-3-540-93936-8_51

Cited by 2 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Within this context, we investigate the deposition of drug-releasing HA coatings to polyamide 12 (PA12) balloon catheter surfaces as exemplary implant application. PA12 is a popular material for balloon catheter due to its good deformability and high burst strength [18]. With the purpose to generate well-adhering HA coatings, plasma-and wet-chemical reactions are investigated with regard to the creation of functional groups on the PA12 surface, subsequent covalent attachment of a HA base layer, and resulting coating morphology.…”

Section: Introductionmentioning

confidence: 99%

Development and In Vitro Characterization of Hyaluronic Acid‐Based Coatings for Implant‐Associated Local Drug Delivery Systems

Petersen

Kaule

Teske

et al. 2013

Journal of Chemistry

View full text Add to dashboard Cite

The development of drug-eluting coatings based on hyaluronic acid (HA) is especially promising for implant-associated local drug delivery (LDD) systems, whose implantation provokes high insertion forces, as, for instance, cochlear implants or drug-coated balloons (DCB). The lubricious character of HA can then reduce the coefficient of friction and serve as drug reservoir simultaneously. In this context, we investigated several plasma- and wet-chemical methods for the deposition of HA-based coatings with LDD function on polyamide 12 as a model implant surface, conventionally used for DCB. In contrast to aminosilane, epoxy silane surface layers allowed the covalent attachment of a smooth and uniform HA base layer, which provided good adherence of further HA layers deposited by manual dip coating at a subsequent processing stage. The applied HA-crosslinking procedure during dip coating influences the transfer and release of paclitaxel, which could be reproducibly incorporated via infiltration. While crosslinking with N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride provided HA coatings on DCB, which allowed for an efficient paclitaxel transfer upon expansion in a vessel model, crosslinking with glutardialdehyde resulted in a slower drug release being more appropriate for implants with longer residence time in the body. The developed HA coating is hence well suited for spontaneous and sustained LDD.

show abstract

Section: Introductionmentioning

confidence: 99%

Development and In Vitro Characterization of Hyaluronic Acid‐Based Coatings for Implant‐Associated Local Drug Delivery Systems

Petersen

Kaule

Teske

et al. 2013

Journal of Chemistry

View full text Add to dashboard Cite

show abstract

“…They can be heavily harmful, potentially leading to severe troubles such as Alzheimer's, allergic reactions, and cancer [7][8][9]. There are also serious concerns regarding the above alloys' elastic moduli that are still much higher than bones (10-30 GPa) [10]. The discrepancy between Young's modulus of implant and bone causes the stress-shielding effect that induces bone resorption and jeopardizes the long-term treatment.…”

Section: Introductionmentioning

confidence: 99%