“…None of these trials found a significant difference in postoperative SWI between single-dose and multiple-dose regimens. The antibiotics that were investigated in these trials were cefoxitin, 38,81 cefuroxime plus metronidazole, 14 metronidazole, 34 ampicillin plus metronidazole, 69,74 co-amoxiclav, 23 latamoxef, 60 mezlocillin plus metronidazole, 27,58,98 ticarcillin/clavulanic acid, 40 cefotaxime plus metronidazole, 81 gentamicin plus ornidazole, 154 piperacillin plus tinidazole, 148 doxycycline, 54 and cefotaxime. 88 When the results from these 17 trials were pooled, there was no significant difference between the single-and multiple-dose groups (10.6% versus 9.7%; odds ratio = 1.17; 95% CI: 0.89, 1.54).…”