2015
DOI: 10.1016/j.ijrobp.2015.06.016
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Single Vocal Cord Irradiation: Image Guided Intensity Modulated Hypofractionated Radiation Therapy for T1a Glottic Cancer: Early Clinical Results

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Cited by 52 publications
(75 citation statements)
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References 23 publications
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“…The group from Erasmus Medical Center Cancer Institute has previously assessed dosimetric feasibility of focal vocal cord irradiation for early‐stage local cancer T1aN0 using 4D‐CT; they showed sparing of contralateral vocal cord and various laryngeal structures compared to conventional radiotherapy . The same group recently published the first clinical outcomes from a retrospective analysis of 30 patients with T1aN0 glottic cancer treated with single vocal cord to a dose of 58 Gy in 16 fractions and showed excellent 2 year LC of 100% . In that study, CTV to PTV margin was defined as an isotropic margin of 3 mm for the first five patients, and was then increased to 5 mm based on observed intra‐fraction target motion for the remaining patients.…”
Section: Discussionmentioning
confidence: 99%
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“…The group from Erasmus Medical Center Cancer Institute has previously assessed dosimetric feasibility of focal vocal cord irradiation for early‐stage local cancer T1aN0 using 4D‐CT; they showed sparing of contralateral vocal cord and various laryngeal structures compared to conventional radiotherapy . The same group recently published the first clinical outcomes from a retrospective analysis of 30 patients with T1aN0 glottic cancer treated with single vocal cord to a dose of 58 Gy in 16 fractions and showed excellent 2 year LC of 100% . In that study, CTV to PTV margin was defined as an isotropic margin of 3 mm for the first five patients, and was then increased to 5 mm based on observed intra‐fraction target motion for the remaining patients.…”
Section: Discussionmentioning
confidence: 99%
“…6,26,28 The same group recently published the first clinical outcomes from a retrospective analysis of 30 patients with T1aN0 glottic cancer treated with single vocal cord to a dose of 58 Gy in 16 fractions and showed excellent 2 year LC of 100%. 7 In that study, CTV to PTV margin was defined as an isotropic margin of 3 mm for the first five patients, and was then increased to 5 mm based on observed intra-fraction target motion for the remaining patients. Our prospective study is limited by the fact that no clinical outcomes using the proposed margins are reported.…”
Section: Discussionmentioning
confidence: 99%
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“…Newer treatment approaches utilize intensity modulated radiotherapy to treat the larynx while sparing the adjacent carotid arteries and achieves 88% local control rate at three years for T1–2N0 glottic SCC . This highly accurate localized treatment has been taken one step further by a Dutch group who limited radiotherapy to the single involved vocal cord and reported a two‐year local control rate of 100% . Some of these T1/T2 patients will not be cured by radiotherapy and some will subsequently undergo salvage total laryngectomy (STL‐LOR).…”
Section: Discussionmentioning
confidence: 99%
“…treatment has been taken one step further by a Dutch group who limited radiotherapy to the single involved vocal cord and reported a two-year local control rate of 100%. 25 Some of these T1/T2 patients will not be cured by radiotherapy and some will subsequently undergo salvage total laryngectomy (STL-LOR).…”
Section: Discussionmentioning
confidence: 99%