Single-Walled Carbon Nanotubes Can Induce Pulmonary Injury in Mouse Model

Chou, Chih-Hsing; Hsiao, Hsin-Huang Michael; Hong, Qi-Sheng; Chen, Chun-Houh; Peng, Yawen; Chen, Huei‐Wen; Yang, Pan‐Chyr

doi:10.1021/nl0723634

Cited by 272 publications

(175 citation statements)

References 40 publications

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“…In other hand, it is possible that nanomaterials generate inflammatory responses in intracellular location. For example, CNTs can induce oxidative stress and increase proinflammatory cytokines and antiapoptotic gene expression by activating various transcription factors such as nuclear factor κB and activator protein 1 and overproduction of TNF-a by macrophages (Muller et al, 2005;Chou et al, 2008). It has been sufficiently demonstrated that maternal inflammation may induce adverse effects in fetal neurodevelopment (Mahmood et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Biosafety of multiwalled carbon nanotube in mice: a behavioral toxicological approach

2012

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-Multiwalled carbon nanotubes (MWCNTs) with unique chemical and electromechanical properties are ideal candidates for the development of drug delivery platforms. The scarce knowledge for the effects of exposure to MWCNTs during pregnancy on postnatal outcomes motivated us to investigate whether intraperitoneal injections (i.p.) of MWCNTs during mating and early pregnancy affect on reproductive and neurobehavioral endpoints and psychobiological status of pups. Thirty virgin female mice were divided to three groups (n = 10 for each); two treated groups injected i.p. with 1 and 10 mg of MWCNTs suspended in 1 ml of phosphate buffered saline solution (PBS) in both mating day and gestation day 3, respectively. The control group was injected i.p. with an equal volume of PBS as a vehicle. MWCNT-treated dams did not exhibit considerable changes in their reproductive performance in gestation and lactation periods. MWCNT-treated pups exhibited similar ontogenetic expressions of neurobehavioral and physical endpoints as compared with control group. Most notably, exposure to MWCNTs was increased depressive and anxious behaviors of treated pups in parallel to adverse effect on their internal organ weights. The absolute thymus weight was declined in MWCNT-treated groups while absolute weights of liver and spleen decreased in group treated by 1 mg of MWCNT as compared to control group. Relative organ weights in MWCNT-treated groups were almost similar to control group.

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Section: Discussionmentioning

confidence: 99%

Biosafety of multiwalled carbon nanotube in mice: a behavioral toxicological approach

2012

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“…Compared to inhalation exposure, intratracheal instillation typically delivers a higher dose to animals. 64 [65][66][67]73,74 and fibrotic lung injury. 65 After intratracheal instillation, nanoparticles were taken up by both the alveolar macrophages and the alveolar epithelial cells.…”

Section: Respiratory Toxicitymentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

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“…That was the case of the study of multi-walled carbon nanotubes acting in a mouse model, where no induction of inflammation was showed, while macrophage activation and development of the inflammatory response was observed for single-walled carbon nanotubes. [14,15] In the last decade, a lot of methods for the synthesis of AuN with the defined parameters, such as size or shape was developed.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

Barbasz

Oćwieja

2015

Journal of Experimental Nanoscience

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Gold nanoparticles (AuN) are one of the most investigated nanomaterials, finding numerous applications from medicine to industry. AuN were obtained by reduction of gold salts using tannic acid as a reducing agent. To detach the impact of AuN onto cells of two lines human monocytic cells (U-937) and human promyelocytic leukaemia cells (HL-60), the effects of postreaction residues (of effluent from sol cleaning) and gold ions were also examined. It was demonstrated that resistance of cells to the toxic action of AuN is dependent not only on incubation time and dosage, but also on stages of cell differentiation. It was found that after incubation of promonocytes U-937 with 25 ppm AuN, the cell viability decreased by 25% and of macrophages by 50%. Differentiated cells U-937 showed a significantly lower resistance than the not-differentiated cells. For HL-60 cells, regardless of differentiation, cell viability decreased by approximately 20% after treatment with 25 ppm AuN sol. It was noticed that U-937 exhibited higher vulnerability to AuN than HL-60 cells. It was proved that AuN induced over a 15-fold increase in nitric oxide and a decrease of intracellular glutathione levels indicating the inflammatory response of cells. Even though gold ions did not show a significant effect on cell viability, they caused fivefold increase of nitric oxide level. The results show a higher cytotoxicity of AuN than gold ions. An overall picture of the interaction of AuN with human cells of first defence line was obtained. The results indicate that AuN may cause changes in the response of phagocytes in inflammatory conditions.

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Single-Walled Carbon Nanotubes Can Induce Pulmonary Injury in Mouse Model

Cited by 272 publications

References 40 publications

Biosafety of multiwalled carbon nanotube in mice: a behavioral toxicological approach

Biosafety of multiwalled carbon nanotube in mice: a behavioral toxicological approach

Perturbation of physiological systems by nanoparticles

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

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