Single x-ray transmission system for bone mineral density determination

Jiménez-Mendoza, Daniel; Espinosa-Arbeláez, D.G.; Giraldo-Betancur, Astrid L.; Hernández-Urbiola, Margarita I.; Vargas-Vázquez, D.; Rodríguez‐García, Mario E.

doi:10.1063/1.3666864

Cited by 10 publications

(12 citation statements)

References 12 publications

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“…After image calibration to optical density, the bone area was delimited using the automatic selection tool and the mean grey intensity for each pixel in the delimited area quantified in arbitrary units (a.u.) 11,13,17 .…”

Section: Evaluation Of Bd By Drxmentioning

confidence: 99%

“…Thus, each pixel is associated with a number representing the color of in the area or the intensity of gray tones. In this way, the image is converted into a set of numbers and can be visualized on a computer screen or be printed for analysis 12,13 . To date, DRx has not been used for analysis of mineral and bone disorder (MBD) in experimental models of CKD.…”

Section: Introductionmentioning

confidence: 99%

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Digital radiography as an alternative method in the evaluation of bone density in uremic rats

et al. 2020

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Introduction: Digital radiography (DRx) may provide a suitable alternative to investigate mineral and bone disorder (MBD) and loss of bone density (BD) in rodent models of chronic kidney disease (CKD). The objective of this study was to use DRx to evaluate BD in CKD rats, and to evaluate the correlation between DRx findings and serum MBD markers and bone histomorphometry. Methods: Uremia was induced by feeding Wistar rats an adenine-enriched diet (0.75% for 4 weeks/0.10% for 3 weeks); outcomes were compared to a control group at experimental weeks 3, 4, and 7. The following biochemical markers were measured: creatinine clearance (CrC), phosphate (P), calcium (Ca), fractional excretion of P (FeP), alkaline phosphatase (ALP), fibroblast growth factor-23 (FGF-23), and parathyroid hormone (PTH). DRx imaging was performed and histomorphometry analysis was conducted using the left femur. Results: As expected, at week 7, uremic rats presented with reduced CrC and higher levels of P, FeP, and ALP compared to controls. DRx confirmed the lower BD in uremic animals (0.57±0.07 vs. 0.68 ± 0.06 a.u.; p = 0.016) compared to controls at the end of week 7, when MBD was more prominent. A severe form of high-turnover bone disease accompanied these biochemical changes. BD measured on DRx correlated to P (r=-0.81; p = 0.002), ALP (r = -0.69, p = 0.01), PTH (r = -0.83, p = 0.01), OS/BS (r = -0.70; p = 0.02), and ObS/BS (r = -0.70; p = 0.02). Conclusion: BD quantified by DRx was associated with the typical complications of MBD in CKD and showed to be viable in the evaluation of bone alterations in CKD.

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Section: Evaluation Of Bd By Drxmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Digital radiography as an alternative method in the evaluation of bone density in uremic rats

et al. 2020

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“…Thus, scientists have studied the possibility of developing a new, affordable and reliable single X-ray absorption system. The method is to use a single X-ray source, X-ray sensor and computer platform, which together, in general, will allow you to calculate the mineral density of the bone (Jimenez-Mendoza et al, 2011). Known methods of computed tomography, digital radiography, and magnetic resonance are sufficiently sensitive to study bone residual material and to determine the causes of death of animals (Amadasi et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

X-ray densitometric indices of proximal phalanx, medial phalanx and ungular pelvic limb bones as criteria for age diagnosis of cattle in forensic veterinary expertise

Yatsenko

Tkachuk

Busol

et al. 2019

Regul. Mech. Biosyst.

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Morphological parameters of biological material are extremely informative in diagnostic studies, in particular, to determine the species, sex, time of death, the term of burial. The most informative object for these tasks is the skeleton, because changes in the bones are stored for a long time, while soft tissue is subjected to rotting. Bone tissue is the most durable, but at the same time, it is very labile and reacts to all metabolic processes in the body. The object of the study was proximal phalanx, medial phalanx and ungular bone of the pelvic limb of cattle ranging in age from newborn to 12 years old. Radiography of the proximal phalanx, medial phalanx and ungular bones of the pelvic limb was performed on the Arman apparatus. The bones were subjected to X-ray in the lateromedial projection. The inner and outer sections of the tubular bone were determined. The mathematical modeling of the interaction of X-rays and the cortical layer of bones of fingers (proximal phalanx, medial phalanx and ungular) of cattle was carried out in this work. It is established that this process is described by Bouger's law. The physico-mathematical model of proximal phalanx, medial phalanx and ungular bones has been calculated, on the basis of which it was possible to calculate the X-ray densitometric indices of these bones of cattle. The age features of dynamics of X-ray densitometric indices of the proximal phalanx, medial phalanx and ungular bones were established and a method of determining the age of cattle according to this criterion was proposed. A mathematical model for the proximal phalanx, medial phalanx and ungular bones of the pelvic limbs of cattle that can be applied in X-ray densitometry uses: for the average third proximal phalanx – section of heterogeneous tubular structure modeled by a semicircle; for a medial phalanx bone – a section of a triangular shape; for the ungular bone – a heterogeneous structure, the plantar surface is inscribed in a rectangle. The process of interaction of X-rays with the bone structure of the examined pelvic limb bones can be described by Bouguer's law. The developed mathematical modeling of this interaction and the algorithm for its analysis is the basis for determining the age of cattle for X-ray densitometric indices of the proximal phalanx, medial phalanx and ungular bones of pelvic limbs. By X-ray densitometry of the proximal phalanx and medial phalanx bones of the pelvic limbs extremities one can diagnose the age of bovine animals from birth to 5 years, but according to ungular bones – from birth to 10 years. X-ray densitometry of medial phalanx and ungular bones of pelvic limbs can be used for diagnosing bovine cattle in a complex with other morphological, chemical and physical methods of investigation.

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“…To our best knowledge, there is no study yet conducted on a large sample of the Chinese population with healthy controls that directly relates dietary iron intake to OP. In the present study, the BMD was measured by using radiographic absorptiometry (RA), which has been proven to be a portable, versatile and accurate measurement instrument . It has been long used as a pre‐screening tool in developing countries, as it enables the diagnosis to be ruled out in half of the population at a low cost .…”

Section: Introductionmentioning

confidence: 99%

“…In the present study, the BMD was measured by using radiographic absorptiometry (RA), which has been proven to be a portable, versatile and accurate measurement instrument. 15 It has been long used as a pre-screening tool in developing countries, as it enables the diagnosis to be ruled out in half of the population at a low cost. 16 Thus, this cross-sectional study aimed to examine the association between dietary iron intake and phalangeal OP in the aforementioned population group.…”

Section: Introductionmentioning

confidence: 99%

Association between dietary iron intake and bone mineral density: A cross‐sectional study in Chinese population

Xiong

Wei

Zeng

et al. 2016

Nutrition & Dietetics

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Aim:The incidence of osteoporosis is rising continuously along with the ageing process in the Chinese population. Iron is an important trace element for bone growth, development and maintenance. However, the association of dietary iron with bone mineral density has not been widely investigated. The present study examined the crosssectional association between dietary iron intake and phalangeal osteoporosis in the Chinese population. Methods: A total of 1870 subjects were included. Dietary intake was assessed using a semi-quantitative food frequency questionnaire. Bone mineral density scans were performed at the middle phalanges of the second, third and fourth fingers of the non-dominant hand. Then, a multivariable logistic analysis model was adopted to test the relationship between dietary iron intake and phalangeal osteoporosis after adjusting a number of potential confounding factors. Results: A modest inverse association between dietary iron intake and phalangeal osteoporosis was observed in the model adjusted by a set of factors, including sex, age, body mass index, smoking status, alcohol drinking status, exercise intensity, waist circumference, total energy intake, calcium intake, fibre intake, nutrient supplementation, history of hypertension and history of diabetes. This association existed both in the total subjects and in the female subgroup, especially in the postmenopausal female subgroup, but not in the male subgroup. Conclusions:The findings of the present study indicated that proper dietary iron intake may play a positive role in the prevention of osteoporosis in the female subgroup, especially in the postmenopausal female subgroup.

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Single x-ray transmission system for bone mineral density determination

Cited by 10 publications

References 12 publications

Digital radiography as an alternative method in the evaluation of bone density in uremic rats

Digital radiography as an alternative method in the evaluation of bone density in uremic rats

X-ray densitometric indices of proximal phalanx, medial phalanx and ungular pelvic limb bones as criteria for age diagnosis of cattle in forensic veterinary expertise

Association between dietary iron intake and bone mineral density: A cross‐sectional study in Chinese population

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