Singlet Oxygen Delivery Through the Porous Cap of a Hollow-Core Fiber Optic Device

Zamadar, Matibur; Aebisher, David; Greer, Alexander

doi:10.1021/jp907945c

Cited by 13 publications

(25 citation statements)

References 23 publications

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“…Only recently was a fiber‐optic singlet oxygen (FOSG) device developed for the localized “delivery” of singlet oxygen (Scheme 1) (1). The device consisted of a porous Vycor glass (PVG) cap coated with meso ‐tetra( N ‐methyl‐4‐pyridyl)porphine ( 1 ) fixed to the end of a hollow fiber‐optic (1). The hollow fiber flowed O 2 gas and guided 532 nm light from a continuous‐wave or pulsed laser.…”

Section: Introductionmentioning

confidence: 99%

Fiber‐optic Singlet Oxygen [¹O₂ (¹Δ_g)] Generator Device Serving as a Point Selective Sterilizer

Aebisher

Zamadar

Mahendran

et al. 2010

Photochem & Photobiology

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Traditionally, Type II heterogeneous photo-oxidations produce singlet oxygen via external irradiation of a sensitizer and external supply of ground-state oxygen. A potential improvement is reported here. A hollow-core fiber-optic device was developed with an “internal” supply of light and flowing oxygen, and a porous photosensitizer-end capped configuration. Singlet oxygen was delivered through the fiber tip. The singlet oxygen steady-state concentration in the immediate vicinity of the probe tip was ca 20 fM by N-benzoyl-DL-methionine trapping. The device is portable and the singlet oxygen-generating tip is maneuverable, which opened the door to simple disinfectant studies. Complete Escherichia coli inactivation was observed in 2 h when the singlet oxygen sensitizing probe tip was immersed in 0.1 mL aqueous samples of 0.1–4.4 × 107 cells. Photobleaching of the probe tip occurred after ca 12 h of use, requiring baking and sensitizer reloading steps for reuse.

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Section: Introductionmentioning

confidence: 99%

Fiber‐optic Singlet Oxygen [¹O₂ (¹Δ_g)] Generator Device Serving as a Point Selective Sterilizer

Aebisher

Zamadar

Mahendran

et al. 2010

Photochem & Photobiology

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“…This photooxidation of 4 leads to formation of N-benzoyl-DL-methionine sulfoxide anion 5; it is an indirect method to measure the 1 O 2 production. Upon flow of oxygen through the fiber, and irradiation at one end of the fiber with 532 nm laser light, at the other end of the fiber sulfoxide 5 was formed [46]. The reported system is interesting since local concentrations of singlet oxygen can be delivered via introduction and withdrawal of the fiber tip.…”

Section: Free-base Porphyrins Generating Singlet Oxygenmentioning

confidence: 99%

Porphyrins functionalized by quaternary pyridinium units

Girek

Śliwa

2013

J. Porphyrins Phthalocyanines

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In this review, free-base and metalloporphyrins, functionalized on meso-positions by quaternary pyridinium units, also referred to as cationic porphyrins, are presented. The article consists of five parts. In the first part free-base porphyrins are described, especially taking account on generation of singlet oxygen; next parts concern metalloporphyrins. The second and third parts deal with zinc and manganese porphyrins, respectively; in the fourth part copper, palladium, and platinum porphyrins are presented. In the fifth part, describing porphyrins with various metal ions an attention is paid to porphyrin metal-organic frameworks (MOFs) and metal-organic materials (MOMs) in which metalloporphyrins are immobilized; syntheses and characterization of obtained products are shown.

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“…To address the critical knowledge gap, a cationic porphyrin, meso ‐tetra( N ‐methyl‐4‐pyridyl)porphine tetrachloride (TMPyP) (Fig. ) was used as singlet oxygen photosensitizer.…”

Section: Introductionmentioning

confidence: 99%

Effect of Toxic Metal Ions on Photosensitized Singlet Oxygen Generation for Photodegradation of Polyaromatic Hydrocarbon Derivatives and Inactivation of Escherichia coli

Herschmann

Ali

Harris

et al. 2018

Photochem & Photobiology

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Here, we report an experimental study of the effect of toxic metal ions on photosensitized singlet oxygen generation for photodegradation of PAH derivatives, Anthracene‐9,10‐dipropionic acid disodium salt (ADPA) and 1,5‐dihydroxynapthalene (DHN) and photoinactivation of Escherichia coli bacteria by using cationic meso‐tetra(N‐methyl‐4‐pyridyl)porphine tetrachloride (TMPyP) as a singlet oxygen photosensitizer. Three s‐block metals ions, such as Na+, K+ and Ca2+ and five toxic metals such as Cd2+, Cu2+, Hg2+, Zn2+ and Pb2+ were studied. The s‐block metal ions showed no change in the rate of photodegradation of ADPA or DHN by TMPyP, whereas a dramatic change in the photodegradation of ADPA and DHN was observed in the presence of toxic metals. The maximum photodegradation rate constants of ADPA and DHN were observed for Cd2+ ions [(3.91 ± 0.20) × 10−3 s−1 and (7.18 ± 0.35) × 10−4 s−1, respectively]. Strikingly, the photodegradation of ADPA and DHN was almost completely inhibited in the presence of Hg2+ ions and Cu2+ ions. A complete inhibition of growth of E. coli was observed upon visible light irradiation of E. coli solutions with TMPyP and toxic metal ions particularly, Cd2+, Hg2+, Zn2+ and Pb2+ ions, except for Cu2+ ions where a significantly slow inhibition of E. coli's growth was observed.

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Singlet Oxygen Delivery Through the Porous Cap of a Hollow-Core Fiber Optic Device

Cited by 13 publications

References 23 publications

Fiber‐optic Singlet Oxygen [¹O₂ (¹Δ_g)] Generator Device Serving as a Point Selective Sterilizer

Fiber‐optic Singlet Oxygen [¹O₂ (¹Δ_g)] Generator Device Serving as a Point Selective Sterilizer

Porphyrins functionalized by quaternary pyridinium units

Effect of Toxic Metal Ions on Photosensitized Singlet Oxygen Generation for Photodegradation of Polyaromatic Hydrocarbon Derivatives and Inactivation of Escherichia coli

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Singlet Oxygen Delivery Through the Porous Cap of a Hollow-Core Fiber Optic Device

Cited by 13 publications

References 23 publications

Fiber‐optic Singlet Oxygen [1O2 (1Δg)] Generator Device Serving as a Point Selective Sterilizer

Fiber‐optic Singlet Oxygen [1O2 (1Δg)] Generator Device Serving as a Point Selective Sterilizer

Porphyrins functionalized by quaternary pyridinium units

Effect of Toxic Metal Ions on Photosensitized Singlet Oxygen Generation for Photodegradation of Polyaromatic Hydrocarbon Derivatives and Inactivation of Escherichia coli

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Fiber‐optic Singlet Oxygen [¹O₂ (¹Δ_g)] Generator Device Serving as a Point Selective Sterilizer

Fiber‐optic Singlet Oxygen [¹O₂ (¹Δ_g)] Generator Device Serving as a Point Selective Sterilizer