Singleton pregnancy outcomes after assisted and non‐assisted reproductive technology in infertile patients

Tsutsumi, Ryo; Fujimoto, Akihisa; Osuga, Yutaka; Ooi, Nagisa; Takemura, Yuri; Koizumi, Minako; Yano, Tetsu; Taketani, Yuji

doi:10.1007/s12522-012-0125-x

Cited by 7 publications

(5 citation statements)

References 26 publications

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“…Thirty‐four studies met inclusion criteria (Figure 1). 23–54 There were 33 cohort studies and one case‐control study. No randomized trials were identified and no isolated abstracts or unpublished studies were identified that met eligibility criteria.…”

Section: Resultsmentioning

confidence: 99%

“…Among those finding an increased risk following in vitro methods, conclusions were mixed with regard to whether the risk was due to the procedure itself or the condition of infertility. Four studies made explicit comparisons to pregnancies with a history of infertility, but not conceiving with in vitro methods 28,41,48,56 . Three 28,41,56 suggested that the increased risk of stillbirth was more related to a history of subfertility, while Wisborg et al 48 .…”

Section: Resultsmentioning

confidence: 99%

“…Four studies made explicit comparisons to pregnancies with a history of infertility, but not conceiving with in vitro methods. 28,41,48,56 Three 28,41,56 suggested that the increased risk of stillbirth was more related to a history of subfertility, while Wisborg et al 48 concluded that the risk was related to the treatment rather than the history of infertility.…”

Section: Description Of Cohort Studiesmentioning

confidence: 99%

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Risk of stillbirth in singleton gestations following in vitro methods of conception: a systematic review and meta‐analysis

Wong

Carson

Crane

2021

BJOG

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Background In vitro methods of conception are associated with adverse perinatal outcomes. It is unclear if the risk of stillbirth is increased also. Objective This systematic review and meta‐analysis aimed to estimate the risk of stillbirth in singleton gestations following in vitro methods of conception compared to non‐in vitro conceptions. Search strategy A comprehensive search in PubMed, Embase, CINAHL, and Cochrane Library was undertaken from database inception to February 2021, with backward citation tracking. Selection criteria Eligible studies included randomized controlled trials, cohort studies, or case‐control studies that assessed stillbirth following in vitro fertilisation and/or intracytoplasmic sperm injection in comparison to non‐in vitro methods of conception, including spontaneous conceptions, intrauterine insemination, and ovarian stimulation. Data collection and analysis The Newcastle‐Ottawa Scale was used to assess risk of bias. A summary odds ratio (OR) for stillbirth following in vitro methods of conception compared to non‐in vitro methods was calculated using a random‐effects model for meta‐analysis. Main results Thirty‐three cohort studies met inclusion criteria. There was an increased risk of stillbirth with in vitro methods: OR 1.41 (95% CI 1.20–1.65); however, the crude baseline risk of stillbirth was low (4.44/1000 total births). Subgroup analysis did not demonstrate an increased risk when in vitro methods were compared to conception without in vitro methods in the context of subfertility. Conclusions Compared to non‐in vitro conceptions, in vitro conceptions have an increased risk of stillbirth. However, there is insufficient evidence to demonstrate whether this risk is associated with in vitro techniques or underlying subfertility. Tweetable abstract This meta‐analysis found an increased risk of stillbirth in singletons from in vitro methods of conception.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Description Of Cohort Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Risk of stillbirth in singleton gestations following in vitro methods of conception: a systematic review and meta‐analysis

Wong

Carson

Crane

2021

BJOG

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“…Though several investigations have studied maternal and perinatal outcomes of ART conception [8, 13–16] or outcomes of natural pregnancy complicated by GDM [17–20], to the best of our knowledge, no prospective cohort study has yet compared GDM -related outcomes between assisted conception and spontaneous pregnancies. A recent retrospective study done by Szymanska et al [21], compared maternal and neonatal outcomes of GDM between women who underwent in vitro fertilization (IVF) and non-IVF women.…”

Section: Introductionmentioning

confidence: 99%

Obstetric and perinatal outcomes of singleton pregnancies conceived via assisted reproductive technology complicated by gestational diabetes mellitus: a prospective cohort study

Kouhkan

Khamseh

Pirjani

et al. 2018

BMC Pregnancy Childbirth

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BackgroundGrowing evidence indicates that the risk of obstetric and perinatal outcomes is higher in women with assisted reproductive technology (ART). However, there is little known about pregnancy related complications and co-morbidity in gestational diabetes mellitus (GDM) following singleton pregnancies achieved by ART in comparison with spontaneous conception (SC).MethodsTwo hundred sixty singleton pregnant women conceived by ART and 314 pregnant women conceived by spontaneous conception (SC) were participated in this prospective cohort study. All participants were enrolled after GDM screening through one-step oral glucose tolerance test (OGTT) and then grouped into GDM and non-GDM groups. Women were followed for pregnancy outcomes including pregnancy-induced hypertension (PIH), preeclampsia, antepartum hemorrhage (APH), cesarean section (CS), preterm birth (PTB), intrauterine growth restriction (IUGR), being small or large for gestational age (SGA or LGA), macrosomia, low birth weight (LBW), respiratory distress, neonatal hypoglycemia, NICU admission and perinatal mortality from antenatal visits to delivery. Confounding factors were adjusted in logistic regression model in order to estimate adjusted odds ratios (aORs).ResultsAmong 260 ART and 314 SC, 135 and 152 women were GDM women, respectively. Higher maternal age and pre-gravid BMI, shorter duration of gestation and lower gestational weight gain were observed in GDM groups (ART-GDM and SC-GDM) compared to those of the SC group. ART-GDM group had a higher risk (95% confidence interval) of obstetric complications including PIH [aOR:7.04 (2.24–22.15)], preeclampsia [aOR:7.78 (1.62–37.47)], APH [aOR:3.46 (1.28–9.33)], emergency CS [aOR:2.64 (1.43–4.88)], and perinatal outcomes such as PTB [aOR:3.89 (1.51–10.10)], LBW [aOR:3.11 (1.04–9.30)] and NICU admission [aOR:4.36 (1.82–10.45)], as well as neonatal hypoglycemia [aOR: 4.91 (1.50–16.07)], compared to SC group. SC-GDM group showed a higher risk of PIH [aOR: 4.12 (1.31–12.89)], emergency CS [aOR: 2.01 (1.09–3.73] and LGA [aOR: 5.20 (1.07–25.20)], compared to SC group. Additionally, ART group had a higher risk of PIH [aOR: 3.46(1.02–11.68), preeclampsia 5.29 (1.03–27.09), and NICU admission [aOR: 2.53 (1.05–6.09)] compared to SC. Insulin requirement (41.8% vs. 25.7%) was significantly higher in ART-GDM group compared to SC-GDM group.ConclusionThe findings of this study suggest that GDM occurring after ART conception increases the risk of adverse obstetric and perinatal outcomes.

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“…Tsutsumi et al [20] studied singleton pregnancy outcomes after assisted and non-assisted reproductive technology in infertile patients. They studied Pregnancy outcome parameters such as pregnancy induced hypertension, placenta previa, placental abruption, cesarean delivery, preterm birth, very preterm birth, stillbirth, low birth weight and very low birth weight.…”

Section: Discussionmentioning

confidence: 99%

Ivf versus spontan singleton pregnancies fetal and maternal outcomes in a tertiary care hospital

Cakar

Yavuz

Kutlu

et al. 2018

ijmsci

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ABSTRACT:Background: We aimed to compare perinatal outcomes of intracytoplasmicsperm injection (ICSI) versus naturally (spontaneously) concieved age and parity matched group of singleton pregnants. Methods: Two hundred and sixteen singleton pregnancies aged between 18-45 years old were included in this study. Among all study group, 106 cases were ICSI pregnancies (study group) and 110 cases were spontaneously concieved singleton pregnancies (control group). Pregnancy outcome parameters were: the incidence of chronic hypertension, preeclampsia, gestational hypertension, placenta previa, placental abruption, preterm birth, intrahepatic cholestasis of pregnancy, gestational diabetes, preterm premature rupture of membranes, caesarean delivery. Results: There were no differences in terms of maternal age, BMI, gravidity, parity, gestational weeks at birth and birth weight between ICSI and spontaneously concieved pregnancy groups. Placental abruption, gestational diabetes and cesarean section rates were significantly higher in ICSI pregnancies than spontaneously conceived pregnancies (4.7% vs 0%, 21.7% vs 11.8% and 82.1% vs 68.2%, respectively). There wereno statistically significant differences in terms of chronic hypertension, preeclampsia, gestational hypertension, preterm labor, placenta previa, intrahepatic cholestasis of pregnancy, preterm and term premature rupture of the membranes. Conclusion: ICSI pregnancies have higher adverse perinatal outcomes than spontaneously conceived singleton pregnancies which were matched with age and parity. That's why ICSI pregnancies should be given a detailed counseling about the adverse perinatal outcomes and should be followed up more carefully through the pregnancy.

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Singleton pregnancy outcomes after assisted and non‐assisted reproductive technology in infertile patients

Abstract: ART procedure may itself be a risk factor for the development of placenta previa. Some of the abnormal perinatal outcomes that had been previously attributed to ART, however, may be due to the baseline characteristics of infertile patients.

Cited by 7 publications

References 26 publications

Risk of stillbirth in singleton gestations following in vitro methods of conception: a systematic review and meta‐analysis

Risk of stillbirth in singleton gestations following in vitro methods of conception: a systematic review and meta‐analysis

Obstetric and perinatal outcomes of singleton pregnancies conceived via assisted reproductive technology complicated by gestational diabetes mellitus: a prospective cohort study

Ivf versus spontan singleton pregnancies fetal and maternal outcomes in a tertiary care hospital

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