2022
DOI: 10.3390/cells11040722
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Singular Adult Neural Stem Cells Do Not Exist

Abstract: Adult neural stem cells (aNSCs) are the source for the continuous production of new neurons throughout life. This so-called adult neurogenesis has been extensively studied; the intermediate cellular stages are well documented. Recent discoveries have raised new controversies in the field, such as the notion that progenitor cells hold similar self-renewal potential as stem cells, or whether different types of aNSCs exist. Here, we discuss evidence for heterogeneity of aNSCs, including short-term and long-term s… Show more

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Cited by 8 publications
(17 citation statements)
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References 104 publications
(171 reference statements)
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“…The copyright holder for this preprint this version posted March 1, 2023. ; https://doi.org/10.1101/2023.02. 28.528936 doi: bioRxiv preprint 4 months (4mo; Fig. 1C).…”
Section: Lipr Lowers Body Weight Ameliorates Metabolic Parameters Rel...mentioning
confidence: 99%
See 3 more Smart Citations
“…The copyright holder for this preprint this version posted March 1, 2023. ; https://doi.org/10.1101/2023.02. 28.528936 doi: bioRxiv preprint 4 months (4mo; Fig. 1C).…”
Section: Lipr Lowers Body Weight Ameliorates Metabolic Parameters Rel...mentioning
confidence: 99%
“…The copyright holder for this preprint this version posted March 1, 2023. ; https://doi.org/10.1101/2023.02. 28.528936 doi: bioRxiv preprint anti-obesity compounds. Lipidized analogues of PrRP are a novel class of compounds with robust anorexigenic and anti-obesity effects.…”
Section: Introductionmentioning
confidence: 99%
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“…The diversity of GSC populations can be explained by their spatial and cellular origin, which can include stem cells, progenitor cells, and differentiated cells ( 6 , 28 ). Interestingly, heterogeneity has also been noted in adult neural stem cells (aNSCs), with a spectrum depending on the developmental stages and spatial location of these cells, impacting their self-renewing capabilities and multipotency ( 29 , 30 ). Drawing from the idea that GSCs may arise from aNSCs, this concept can be extrapolated to explain that they share these heterogeneous features as well.…”
Section: Heterogeneity Of Gscs In Gbmmentioning
confidence: 99%