Sinonasal carcinomas – A single‐centre experience at Prince of Wales Hospital, Sydney, Australia, from 1994 to 2016

Abstract

Introduction Sinonasal carcinomas (SNCs) are rare neoplasms that are often diagnosed at advanced stages due to asymptomatic growth of tumours in the spaces of the sinonasal complex. Treatment is associated with high morbidity, and outcomes have only improved slightly in the past few decades despite advancements in treatment modalities. The purpose of this study is to evaluate the efficacy and safety of treatment at our institution. Methods This retrospective cohort study analysed patients who received definitive treatment at the Prince of Wales Hospital (POWH), Sydney, for non‐metastatic SNC. Patients with non‐carcinoma and olfactory neuroblastoma pathology were excluded. Data were collected from the POWH electronic patient database. Survival functions were calculated through Kaplan–Meier analysis, and multivariate analysis for prognostic factors was performed through Cox regression. Results Seventy‐five patients from 1994 to 2016 were eligible for analysis. Overall 5‐year local control (LC), ultimate local control (ULC), overall survival (OS) and cancer‐specific survival (CSS) were 76 ± 6%, 80 ± 5%, 69 ± 6% and 77 ± 5%, respectively. On multivariate analysis, clinical stage was prognostic for LC and primary site was prognostic for OS and CSS. Lymphovascular invasion and tumour inoperability were also predictive of CSS. Conclusion Survival and local control rates at our centre were greater than those reported in the literature. Early‐stage patients treated with surgery alone had excellent oncologic outcomes. Radical surgery with postoperative radiation provides the best outcome in the setting of advanced disease.

Oncologic outcome of multimodality treatment for sinonasal malignancies: An 18-year experience

“…This result is consistent with the moment when our institute started to promote multidiscipline treatment and update the surgical instrument. According to previous studies, the 5-year OS of SNM patients ranged from 69% to 82% ( 13 , 14 ). In this study, the 5-year and 10-year OS were 59.6% and 47.6%, respectively.…”

Empirical comparison of routinely collected electronic health record data for head and neck cancer‐specific survival in machine‐learnt prognostic models

“…The OIS dataset contained routinely collected data for government reporting, extracted using structured query language. The research dataset contained manually curated data extracted from unstructured clinical documents and has been use in several publications 1–3,16–18 …”

“…The research dataset contained manually curated data extracted from unstructured clinical documents and has been use in several publications. 1 , 2 , 3 , 16 , 17 , 18 …”

“…The research dataset contained manually curated data extracted from unstructured clinical documents and has been use in several publications. [1][2][3][16][17][18] Death data were sourced from the National Death Index (NDI) in February 2018 via probabilistic record linkage (EO2017/5/392), the NSW Registry of Births, Death and Marriages, hospital notifications, and the Ryerson Index (death notices and obituaries in Australian newspapers). NDI cause of death data were not available for patients registered as deceased in the 2 years prior to linkage (2016-2017).…”

Treatment Outcomes of Maxillary Sinus Squamous Cell Carcinoma at a Dedicated Cancer Institute: A Retrospective Study

“…Another challenge is the presence of nonspecific and vague symptoms, which can be mistaken for allergic, inflammatory, and infective causes. This is the reason for delayed diagnosis and hence an advanced stage in maxillary sinus malignancies [ 1 , 2 , 10 ]-most of the maxillary sinus malignancies present at stages III and IV. Common symptoms are blood-stained discharge, non-healing lesion, facial swelling, difficulty opening the mouth, and unilateral nasal obstruction.…”