Sinonasal malignancies: A population‐based analysis of site‐specific incidence and survival

Dutta, Rahul; Dubal, Pariket M.; Svider, Peter F.; Liu, James K.; Baredes, Soly; Eloy, Jean Anderson

doi:10.1002/lary.25465

Cited by 149 publications

(158 citation statements)

References 26 publications

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“…They arise from the sinonasal surface epithelium and are most commonly squamous cell carcinoma (SCCA) (50%–60%) . They occur in the nasal cavity most frequently and least frequently in the frontal sinus . Risk factors include age, race, alcohol and tobacco use, environmental exposures, and human papillomavirus infection .…”

Section: Introductionmentioning

confidence: 99%

“…Risk factors include age, race, alcohol and tobacco use, environmental exposures, and human papillomavirus infection . These cancers affect white patients more commonly and occur twice as frequently in men rather than women . Presentation is usually at late, symptomatic stages, contributing to high mortality rates (5‐year survival of 30%–40%) .…”

Section: Introductionmentioning

confidence: 99%

“…The gold standard for treatment involves surgical resection with adjuvant radiotherapy. If total resection is limited by proximity to the orbit and skull base, chemotherapy is often used . Prior studies have shown, however, that outcomes in head and neck cancers as a whole are effected not only by treatment, but also by other factors such as age, race, socioeconomic status (SES), alcohol and tobacco use, stage of disease, and anatomic site of origin …”

Section: Introductionmentioning

confidence: 99%

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Education and insurance status: Impact on treatment and survival of sinonasal cancer patients

2019

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Objectives/Hypothesis To understand the impact of education and insurance as social determinants of health on sinonasal cancer treatment and outcomes. Study Design Retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. Methods Demographics, tumor characteristics, location, stage at diagnosis, treatment, and survival data for 1,365 patients diagnosed with sinonasal cancers were extracted from the SEER database. All statistical analyses were performed using SAS 9.5. The Fine and Grey method was used to assess covariate impacts. Results Medicaid patients were more likely to live in counties with lower educational levels (8.32% vs. 6.46% below ninth grade education, P < .0001) and lower median household incomes ($56,316 vs. $60,284, P = .0004). Medicaid patients presented with later (T3‐T4) stage disease compared to other insurances (P = .0007) and larger tumor size (P = .011). Medicaid patients were less likely to have surgery recommended (P = .0017) or receive surgery as part of their treatment (P = .0033). Analysis of histology‐specific 5‐year survival rates were lower for Medicaid patients with squamous cell carcinoma (SCCA) (P = .016). Conclusions This is the first and largest study to examine how education and insurance status may impact treatment and outcomes in sinonasal cancers. It is the first using this method of examining other covariates and informing associated risk. Patients with Medicaid and less education present with larger sinonasal cancers. They are less likely to have surgery recommended or receive surgery. For SCCA, the most common histology, Medicaid patients have significantly worse survival. Further emphasis on education and improving health literacy is needed in the at‐risk Medicaid populations. Level of Evidence NA Laryngoscope, 130:649–658, 2020

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Education and insurance status: Impact on treatment and survival of sinonasal cancer patients

2019

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“…Most sinuses are anatomically concealed and the first tumor symptoms are often unspecific. Depending on the site of incidence, sinonasal tumor diagnosis is, therefore, often delayed resulting in poor prognosis …”

Section: Introductionmentioning

confidence: 99%

Prognostic survival value of retropharyngeal lymph node involvement in sinonasal tumors: A retrospective, descriptive, and exploratory study

et al. 2017

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“…However, risk factors for development of sinonasal carcinoma are controversial, and unlike oropharyngeal cancer, tobacco smoking is not considered a prominent etiologic agent in the development of sinonasal tract malignancy. On the whole, sinonasal carcinoma appears to have an increased prevalence in Caucasians, confers a relatively low 5‐year disease‐specific survival (53.7%), and most commonly presents as squamous cell carcinoma (41.9%) . Interestingly, in HPV‐related carcinoma with ACC‐like features, the microcystic spaces, vague tumor spindling, and biphasic tumor cells more closely resemble salivary gland carcinoma than conventional HPV‐related squamous cell carcinoma …”

Section: Discussionmentioning

confidence: 99%

Case report: HPV‐related carcinoma with adenoid cystic‐like features of the sinonasal tract

2018

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Human papillomavirus-related carcinoma with adenoid cystic-like features is a newly described histologic variant of sinonasal tract carcinoma. The implications of this sinonasal malignancy is still being evaluated. There are a limited number of cases reported in the literature, and thus we seek to further characterize this patient population and review the histologic features of this malignancy with the following two cases. The behavior of this entity is as yet uncertain. Laryngoscope, 128:1515-1517, 2018.

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Sinonasal malignancies: A population‐based analysis of site‐specific incidence and survival

Abstract: 4.

Cited by 149 publications

References 26 publications

Education and insurance status: Impact on treatment and survival of sinonasal cancer patients

Education and insurance status: Impact on treatment and survival of sinonasal cancer patients

Prognostic survival value of retropharyngeal lymph node involvement in sinonasal tumors: A retrospective, descriptive, and exploratory study

Case report: HPV‐related carcinoma with adenoid cystic‐like features of the sinonasal tract

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