Sinonasal Mucosal Melanoma: A Population-based Comparison of the EUROCARE and SEER Registries

Temmermand, David; Kılıç, Suat; Mikhael, Mina; Butler, Jennifer; Unsal, Aykut A.

doi:10.1055/s-0041-1740099

Cited by 7 publications

(2 citation statements)

References 26 publications

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“…Although its incidence is increasing, SNMM is one of the most common malignant head and neck tumours [ 11 ]. Treatment of SNMM is highly challenging due to the high rate of local recurrence and distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a nomogram for predicting overall survival in patients with sinonasal mucosal melanoma

Zhu,

Wang,

Zha

et al. 2024

BMC Cancer

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Background Sinonasal mucosal melanoma (SNMM) is a relatively rare malignant tumour with a poor prognosis. This study was designed to identify prognostic factors and establish a nomogram model to predict the overall survival (OS) of patients with SNMM. Methods A total of 459 patients with SNMM were selected from the Surveillance, Epidemiology, and End Results (SEER) database as the training cohort. Univariate and multivariate Cox regression analyses were used to screen for independent factors associated with patient prognosis and develop the nomogram model. In addition, external validation was performed to evaluate the effectiveness of the nomogram with a cohort of 34 patients with SNMM from Peking Union Medical College Hospital. Results The median OS in the cohort from the SEER database was 28 months. The 1-year, 3-year and 5-year OS rates were 69.8%, 40.4%, and 30.0%, respectively. Multivariate Cox regression analysis indicated that age, T stage, N stage, surgery and radiotherapy were independent variables associated with OS. The areas under the receiver operating characteristic curves (AUCs) of the nomograms for predicting 1-, 3- and 5-year OS were 0.78, 0.71 and 0.71, respectively, in the training cohort. In the validation cohort, the area under the curve (AUC) of the nomogram for predicting 1-, 3- and 5-year OS were 0.90, 0.75 and 0.78, respectively. Patients were classified into low- and high-risk groups based on the total score of the nomogram. Patients in the low-risk group had a significantly better survival prognosis than patients in the high-risk group in both the training cohort (P < 0.0001) and the validation cohort (P = 0.0016). Conclusion We established and validated a novel nomogram model to predict the OS of SNMM patients stratified by age, T stage, N stage, surgery and radiotherapy. This predictive tool is of potential importance in the realms of patient counselling and clinical decision-making.

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Section: Discussionmentioning

confidence: 99%

Development and validation of a nomogram for predicting overall survival in patients with sinonasal mucosal melanoma

Zhu,

Wang,

Zha

et al. 2024

BMC Cancer

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“…In the region of the head and neck, sinonasal melanoma (SNMM) remains the most common subtype. 1 Because of late diagnosis at an advanced stage due to nonspecific symptoms, the five-year survival rate is no more than 30% in SNNM patients due to its high recurrence and metastatic potential. 2 Although multiple therapeutic modalities have been implemented clinically, the outcomes of SNMM patients remain ominous.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of Tumor-infiltrating Lymphocytes and Anti-programmed Death-ligand 1 Therapy in Sinonasal Mucosal Melanoma: A 10-year Experience at a Single Institution

Tarabay,

Ren,

Ifegu

et al. 2023

J Clin Transl Pathol

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Background and objectives: Sinonasal mucosal melanoma (SNMM) is a rare aggressive malignancy that presents with dismal outcomes and a high metastatic propensity. The prognostic factors as well as therapeutic regimens remain largely unknown due to the rarity of SNMM. This study aimed to assess the characteristics of SNMM patients associated with a better prognosis. Methods: We performed an observational cross-sectional study to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) and anti-programmed death-ligand 1 (PD-L1) therapy in 12 SNNM patients who were diagnosed at our institution and treated with anti-PD-L1 from 2011 to 2021. Results: Of the 12 cases, 5 (41.7%) patients displayed brisk TIL activity, while 7 patients (58.3%) had nonbrisk TIL activity. The BRAF V600E mutation was not identified in any of the 12 cases by mutational analysis. The expression of PD-L1 was identified in 5 out of 10 SNMM cases (50%). Through analyzing the correlation between TILs and prognosis in 12 SNMM patients, we found that brisk TILs might be associated with a better prognosis compared with non-brisk TILs (p = 0.036). Conclusions: Our results imply that awareness of the presence of brisk TILs and PD-L1 expression will provide guidance to clinicians for the treatment of SNMM.

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Sinonasal mucosal melanoma in The Netherlands between 2001 and 2021: a clinical and epidemiological overview of 320 cases

Scheurleer,

van de Velde,

Devriese

et al. 2024

Eur Arch Otorhinolaryngol

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Purpose Sinonasal mucosal melanoma (SNMM) is a rare malignancy, characterised by high (local) recurrence rates and poor survival. Comprehensive understanding of tumour etiology is currently lacking, which complicates adequate tumour treatment. Besides examining trends in incidence, this study aims to assess the association between clinical characteristics, treatment practices and patient outcomes, with the objective of establishing a baseline from which SNMM management can be enhanced. Methods All newly diagnosed SNMM cases in The Netherlands between 2001 and 2021 were included using data from The Netherlands Cancer Registry (NCR). Results A total of 320 patients were included. The annual incidence rate for the overall population was stable over the inclusion period with an annual percentage change (APC) of only − 0.01%. The 5-year overall survival (OS) and relative survival (RS) were 24.5 and 32.4%, respectively. Relative survival did not increase over time. The addition of adjuvant radiotherapy to surgery was not associated with a higher OS and RS compared to surgery alone. Conclusion Sinonasal mucosal melanoma is a rare disease with stable incidence rates in the Netherlands between 2001 and 2021. There has been no improvement in survival over the course of the inclusion period. The study reaffirms that adjuvant radiotherapy does not seem to improve patient outcomes. Given the generally poor outcomes for SNMM patients, novel therapeutic options ought to be considered in order to improve care.

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Sinonasal Mucosal Melanoma: A Population-based Comparison of the EUROCARE and SEER Registries

Cited by 7 publications

References 26 publications

Development and validation of a nomogram for predicting overall survival in patients with sinonasal mucosal melanoma

Development and validation of a nomogram for predicting overall survival in patients with sinonasal mucosal melanoma

Prognostic Significance of Tumor-infiltrating Lymphocytes and Anti-programmed Death-ligand 1 Therapy in Sinonasal Mucosal Melanoma: A 10-year Experience at a Single Institution

Sinonasal mucosal melanoma in The Netherlands between 2001 and 2021: a clinical and epidemiological overview of 320 cases

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