Sinonasal papillomas: A single centre experience on 137 cases with emphasis on malignant transformation and EGFR/KRAS status in “carcinoma ex papilloma”

Maisch, Saskia; Müller, Sarina; Traxdorf, Maximilian; Weyerer, Veronika; Stoehr, Robert; Iro, Heinrich; Hartmann, Arndt; Agaimy, Abbas

doi:10.1016/j.anndiagpath.2020.151504

Cited by 26 publications

(21 citation statements)

References 33 publications

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“…Our cell line also demonstrates a normal short arm of chromosome 7, which contains the epidermal growth factor receptor (EGFR) gene. Mutations to the EGFR gene, specifically within exon 20, have repeatedly been observed in IP 8,9 . In the future, sequencing of IP‐SCC specimens could definitively establish whether EGFR and wild‐type p53 commonly occur.…”

Section: Discussionmentioning

confidence: 98%

“…Mutations to the EGFR gene, specifically within exon 20, have repeatedly been observed in IP. 8,9 In the future, sequencing of IP-SCC specimens could definitively establish whether EGFR and wild-type p53 commonly occur. These 2 intriguing qualities may prove useful for precision medicine treatments for this rare cancer (eg, normal p53 should provide radiosensitization).…”

Section: Discussionmentioning

confidence: 99%

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Establishment and characterization of an inverted papilloma–associated sinonasal squamous cell carcinoma cell line

Swenson

Miller

Wuertz

et al. 2020

Int Forum Allergy Rhinol

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Establishment and characterization of an inverted papilloma–associated sinonasal squamous cell carcinoma cell line

Swenson

Miller

Wuertz

et al. 2020

Int Forum Allergy Rhinol

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“…Moreover, the histologic criteria of malignant transformation have not yet been well defined. Even the current WHO classification has not included "carcinoma ex sinonasal papilloma" among its topics, which might negatively affect the precise diagnosis of such a category [28]. It should also be noted that the IHC profile of this group is yet to be established, despite several IHC studies conducted in this context [27,[29][30][31][32][33][34][35][36][37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

IMP3 Immunohistochemical Expression in Inverted Papilloma and Inverted Papilloma-Associated Sinonasal Squamous Cell Carcinoma

Hakim

Raboh

Shash

2021

Analytical Cellular Pathology

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Sinonasal inverted papilloma (IP) has a propensity for malignant transformation. Although the IP-associated squamous cell carcinoma (SCC) is rare, it has a poor prognosis. To the best of our knowledge, this is the first study to assess IMP3 immunohistochemical (IHC) expression in sinonasal tumors and to compare it to the Ki-67 IHC expression and to other established clinicopathological parameters. A retrospective study was conducted on three groups which consisted of 72 cases of sinonasal IP, 20 age-matched samples of normal respiratory epithelium, and 15 cases of sinonasal SCC associated with IP, which were obtained from the archives of the Pathology Lab of Ain Shams University Specialized and Ain Shams University Hospitals during the period from January 2012 to December 2019. An IHC study was performed to evaluate IMP3 and Ki-67 expression in the three groups, with correlation of IMP3 expression to established clinicopathological parameters of sinonasal SCC on top of IP. Both IMP3 and Ki-67 showed a sharp rise in expression in the sinonasal SCC group. In addition, there were statistically significant differences in expression values between the 3 groups ( P = 0.001 ). Receiver Operating Characteristic (ROC) analysis revealed that IMP3 and Ki-67 could be used to discriminate sinonasal SCC from control and IP lesions, with sensitivity and specificity of 100% and 81.5% for IMP3, respectively, and 100% and 62.5% for Ki-67, respectively. Spearman’s rho revealed that both IMP3 and Ki-67 were significantly related to the lymph node and tumor stages but not to the tumor grade. ROC analysis was performed to select cut-off scores for progression and survival for IMP3, and accordingly, Kaplan-Meier analysis showed correlation between IMP3 and overall survival, local recurrence-free survival, and metastasis-free survival in sinonasal SCC cases at the selected cut-off values. Based on our results, IMP3 could serve as a promising diagnostic, prognostic, and therapeutic marker for IP-associated sinonasal SCC.

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“…Tumour DNA isolation from formalin‐fixed paraffin‐embedded (FFPE) tumour tissue, amplicon‐based massive parallel sequencing with the TST15 panel (Illumina, San Diego, CA, USA) and HRAS hotspot (codons 12, 13, and 61) mutation analysis were performed as described previously 10,11 …”

Section: Methodsmentioning

confidence: 99%

Papillary‐cystic neoplasms of the middle ear are distinct from endolymphatic sac tumours

et al. 2020

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Aims Papillary neoplasms of the middle and inner ear are rare and poorly characterised. The current World Health Organization classification divides them into two major subtypes: aggressive papillary tumours (APTs) and endolymphatic sac tumours (ELSTs). The aim of this article is to present two papillary neoplasms of the middle ear that do not fit into either the classic APT category or the classic ELST category, and compare them with three ELSTs. Methods and results The patients were a 48‐year‐old female and a 59‐year‐old male without a history of other neoplasms. Histology showed papillary‐cystic growth of predominantly oncocytic (Case 1) or mucinous (Case 2) cells surrounded by a p63‐positive basal layer. The overall histology was reminiscent of oncocytic sinonasal papilloma (Case 1) and pancreatobiliary or salivary intraductal papillary mucinous neoplasms (Case 2). Ovarian‐type stroma, invasion and malignant features were absent. Immunohistochemistry revealed expression of cytokeratin (CK) 7, but not carbonic anhydrase IX (CAIX) or paired box gene 8 (PAX8) (except for very focal PAX8 expression in Case 1). The TST15 gene panel and HRAS sequencing revealed no pathogenic mutations in BRAF, KRAS, EGFR, AKT1, or HRAS. The TruSight RNA fusion panel revealed an MKRN1–BRAF fusion in Case 1. No fusion was detected in Case 2. The three ELSTs showed classic features of the entity, expressed CK7, epithelial membrane antigen, PAX8, and CAIX, and lacked a basal cell layer. Conclusion These novel cases suggest that papillary tumours of the ear represent a heterogeneous spectrum of distinct neoplasms unified by a prominent papillary‐cystic pattern rather than a single entity. Future studies should clarify whether the MKRN1–BRAF fusion is a defining recurrent driver event, especially in those cases reported as sinonasal‐type middle ear papillomas.

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Sinonasal papillomas: A single centre experience on 137 cases with emphasis on malignant transformation and EGFR/KRAS status in “carcinoma ex papilloma”

Cited by 26 publications

References 33 publications

Establishment and characterization of an inverted papilloma–associated sinonasal squamous cell carcinoma cell line

Establishment and characterization of an inverted papilloma–associated sinonasal squamous cell carcinoma cell line

IMP3 Immunohistochemical Expression in Inverted Papilloma and Inverted Papilloma-Associated Sinonasal Squamous Cell Carcinoma

Papillary‐cystic neoplasms of the middle ear are distinct from endolymphatic sac tumours

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