Sinonasal Surfactant Protein A1, A2, and D Gene Expression in Cystic Fibrosis: A Preliminary Report

Abstract

Understanding the role of SPs in CRS will help develop novel treatment approaches for sinonasal pathoses.

Eosinophil-Associated Lung Diseases. A Cry for Surfactant Proteins A and D Help?

“…Indeed, early studies using liposomes, which consist of phospholipids that make up 75% of the nasal surfactant layer, have been found to be comparable to cromoglycolate therapy in the treatment of patients with AR (87). In patients with chronic rhinosinusitis associated with cystic fibrosis, expression of SP-A, SP-B, and SP-D is also increased (88,89).…”

Surfactant Protein A and D in Chronic Rhinosinusitis with Nasal Polyposis and Corticosteroid Response

“…There are previous contradictory studies revealing decreased SP-D or increased SP-A and SP-D levels in NP. 6,8 These differences may be associated with the nature, stage, and extent of inflammation and the mucosal pathology. The inflammatory response modulated fluctuations in the levels of SP-A and SP-D during the course of the NP may be one of the responsible mechanisms.…”

“…5 SPs occur in A, B, C, and D subclasses. SP-A and SP-D are the members of the collectin family, 6 which plays a role in the body's innate immune system. Surfactant has been studied intensely in relation to lower respiratory tract disease, and altered levels have been reported.…”

Current views on chronic rhinosinusitis in patients with cystic fibrosis

“…Ядра со-держали дисперсный хроматин как признак повы-шенной активности, а также четко определялась структура аппарата Гольджи. Были изучены по-вреждения экспрессии генов сурфактанта (SP-A1, SP-A2 и SP-D) при различных формах хронического риносинусита, а также МВ [12]. У пациентов с МВ выявлено статистически значимое повышение SP-A1, SP-A2 и РНК по сравнению с контрольной группой.…”