Sinonasal Tract Angiosarcoma: A Clinicopathologic and Immunophenotypic Study of 10 Cases with a Review of the Literature

Abstract

Sinonasal tract angiosarcoma is a rare tumor, frequently presenting in middle-aged patients as a large mass usually involving the nasal cavity with characteristic histomorphologic and immunophenotypic features. Sinonasal tract angiosarcoma will often have a poor prognosis making appropriate separation from other conditions important.

Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions

“…Most importantly, LCHs are an intravascular benign process that does not have intervening stroma seen in JNA and is not an extravascular extension of malignant endothelial cells, leaving their normal pericytic confines and losing SMA, as observed in angiosarcoma [75].…”

Rare angiosarcoma of inferior turbinate; A case report and literature review

“…The tumour behaviour and clinical characteristics might depend on the site of origin. Epistaxis and nasal obstruction was the most frequently identified symptoms in sinonasal tract angiosarcoma (3). Patient also may present with nasal discharge, enlarging nasal mass, sinusitis, epiphora, diplopia, ptosis or headache.…”

“…The size of the primary lesion and presence of distant metastasis were the most useful determinant of treatment options. Surgical resection with radiation and/or chemotherapy is the treatment of choice in head and neck sarcomas (1,3). Radical surgery with complete resection and adjuvant radiotherapy with large doses and wide treatment field was recommended for local disease whereas cytotoxic chemotherapy was the primary treatment for metastatic angiosarcoma (1).…”

“…It is commonly seen in the skin and superficial soft tissues of the head and neck (2,3). Despite this fact, sinonasal angiosarcoma is extremely rare and accounts for less than 0.1% of all sinonasal tract malignancy (3).…”

“…Despite this fact, sinonasal angiosarcoma is extremely rare and accounts for less than 0.1% of all sinonasal tract malignancy (3). Epistaxis and nasal obstruction was the most frequently identified symptoms in sinonasal tract angiosarcoma (3) and surgical resection with radiation and/or chemotherapy is the treatment of choice (1,3).…”