Sinus Arrest Associated With Ticagrelor Therapy: A Case Report and Review of Literature

Zulfiqar, Shaheer; Saleem, Maryam; Jilani, Mohammad Hashim; Siddiqui, Fayez; Arif, Imran; Waqar, Fahad

doi:10.1097/mjt.0000000000001385

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2023

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“…There are many cases in which sinus pauses occur in a non-diseased heart such as in well-conditioned athletes with increased vagal tone, the elderly population, and, most commonly, during sleep in the general population. Sinus pauses can also be the sequelae of other underlying disorders such as fibrosis of the SA node, myocardial ischemia, and metabolic abnormalities such as hypothermia or hyperkalemia [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

A Case of Ticagrelor-Induced Sinus Pause

Pavlatos,

Shah,

Khan

et al. 2023

Cureus

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Ticagrelor is an oral antiplatelet agent commonly used following percutaneous coronary intervention (PCI). There have been many reports describing bradyarrhythmias in the setting of ticagrelor use, most notably sinus pauses. This process is thought to be related to ticagrelor's inhibition of human equilibrative nucleoside transporter (hENT1), which reduces cellular uptake of adenosine. We present a case of a 58-yearold male who experienced prolonged sinus pauses 38 hours after starting ticagrelor following ST-elevation myocardial infarction with subsequent PCI and stent placement.

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Section: Introductionmentioning

confidence: 99%