SIOP PODC: Recommendations for supportive care of children with cancer in a low‐income setting

Israëls, Trijn; Renner, Lorna; Hendricks, Marc; Hesseling, Peter; Howard, Scott C.; Molyneux, Elizabeth

doi:10.1002/pbc.24501

Cited by 82 publications

(92 citation statements)

References 61 publications

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“…The quality of supportive care affects outcome and the Paediatric Oncology in Developing Countries (PODC) group in SIOP has produced guidelines for the supportive care needed to provide safe and effective oncological services in differently staffed and funded settings (Israels et al, 2013). These include infection prevention and free nutritional support.…”

Section: Challenges Of Cancer Care In Lmicsmentioning

confidence: 99%

“…SIOP, GFAOP and the International Network of Cancer Treatment and Research (INCTR) have been involved in developing suitable protocols for treatment of BL in LMICs. SIOP has developed supportive care guidelines for such settings (Israels et al, 2013). In Malawi the use of rituximab in BL is being investigated to try to improve survival without the increased toxicities of intense regimens (Molyneux E.M., unpublished observations).…”

Section: Treatmentmentioning

confidence: 99%

“…Presentation with advanced bulky disease due to lack of knowledge -both of the general public and health providers -makes for a high risk of complications during initial treatment, including tumour lysis syndrome. Malnutrition increases the likelihood of infections, neutropenia and treatment delays (Israels et al, 2013). Poor geographical access in countries with few centres competent to manage childhood cancers affects the time to presentation, treatment completion and follow-up.…”

Section: Specific Challengesmentioning

confidence: 99%

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Haematological cancers in African children: progress and challenges

et al. 2017

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SummaryCancer is increasingly important in low and middle-income settings where infectious diseases are declining. Childhood cancers treated in well-resourced centres have excellent outcomes with more than 80% survival. This success is not reflected in low-income settings where challenges involve every step on the care pathway. Access to diagnosis, delayed presentation, advanced disease, co-morbidities and underlying malnutrition make treatment difficult. Treatments are costly for impoverished families. Yet, the common haematological malignancies (Burkitt lymphoma, Hodgkin lymphoma, non Hodgkin lymphoma) are relatively easy to diagnose and, when managed with simple chemotherapy protocols, give limited but good results. As funding becomes available for cancer research we must ensure that the care and cure of these children is top of the agenda. There is already evidence of improved outcomes in middle-income countries. For others there is a long journey ahead.

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Section: Challenges Of Cancer Care In Lmicsmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Section: Specific Challengesmentioning

confidence: 99%

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Haematological cancers in African children: progress and challenges

et al. 2017

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“…Treatment of febrile neutropenia which is an oncological emergency with early and efficient therapy decreases morbidity and mortality significantly (1). Differences between countries, regions and centers may be observed in terms of the microorganisms which are involved in the etiology of febrile neutropenia (2).…”

Section: Introductionmentioning

confidence: 99%

Febrile neutropenia in children with acute lymphoblastic leukemia: single center experience

et al. 2016

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Aim: An important life-threatening complication of intensive chemotherapy administered in children with leukemia is febrile neutropenia. The objective of this study was to evaluate the clinical features and consequences of febrile neutropenia attacks in children who were treated for acute lymphoblastic leukemia. Material and Methods:Nighty-six children who received chemotherapy for acute lymphoblastic leukemia in our center between January 1995 and December 2010 were included in the study. The data related to demographic characteristics, treatment features, relapse and febrile neutropenia incidences, risk factors, culture results and prognosis were retrospectively evaluated from the patients' files.Results: A total of two hundred-ninety nine febrile neutropenia attacks observed in the patients during initial treatment and relapse treatment were evaluated. When the incidence of febrile neutropenia was evaluated by years, it was observed that the patients treated after year 2000 had statistically significantly more febrile neutopenia attacks compared to the patients treated before year 2000. When the incidences of febrile neutropenia during initial treatment and during relapse treatment were compared, it was observed that more febrile neutropenia attacks occured during relapse treatment. Fifty-nine percent of all febrile neutropenia attacks were fever of unknown origin. Eighty microorganisms grew in cultures during febrile neutropenia throughout treatment in 75 patients; 86% were bacterial infections (50% gram positive and 50% gram negative), 8% were viral infections and 6% were fungal infections. Coagulase negative staphylococcus (n=17) was the most frequent gram positive pathogen; E. Coli (n=17) was the most commonly grown gram negative pathogen. Conclusions:In this study, it was found that an increase in the incidence of febrile neutropenia occured in years. Increments in treatment intensities increase the incidence of febrile neutropenia while improving survival. Evaluation of febrile neutropenia results by hematology-oncology units in years will be directive in early and successful treatment. (Turk Pediatri Ars 2016; 51: 79-86)

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“…Using the graduated intensity philosophy first proposed for the treatment of acute lymphoblastic leukemia, [39] the Adapted Treatment Regimens WG has produced pragmatic guidelines for the management of individual childhood cancers depending on the supportive care facilities available. [19][20][21][22][23][24][25] These guidelines were developed by physicians from LMIC and HIC. Several others including those on the management of children with Hodgkin lymphoma, osteosarcoma, acute myeloid leukemia, and an algorithm for nutritional assessment and intervention are in advanced stages of development.…”

Section: Development Of Adapted Treatment Guidelinesmentioning

confidence: 99%

Improving Care for Children With Cancer in Low- and Middle-Income Countries-A SIOP PODC Initiative

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Challinor

Howard

et al. 2015

Pediatr Blood Cancer

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The Paediatric Oncology in Developing Countries (PODC) committee of International Society of Paediatric Oncology (SIOP) has 10 working groups that provide a forum for individuals to engage, network, and implement improvements in the care of children with cancer in low-and middle-income countries. The development of adapted guidelines (medulloblastoma, retinoblastoma, Wilms tumor, neuroblastoma, retinoblastoma, Burkitt lymphoma, supportive care), advocacy and awareness (on hospital detention and essential drugs), education and training, and global mapping (nutritional practice, abandonment rates, and twinning collaborations) have been the initial areas of focus, and the impact of some of these activities is evident, for example, in the SIOP Africa PODC Collaborative Wilms tumor project.

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SIOP PODC: Recommendations for supportive care of children with cancer in a low‐income setting

Cited by 82 publications

References 61 publications

Haematological cancers in African children: progress and challenges

Haematological cancers in African children: progress and challenges

Febrile neutropenia in children with acute lymphoblastic leukemia: single center experience

Improving Care for Children With Cancer in Low- and Middle-Income Countries-A SIOP PODC Initiative

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