SiRNA Delivery Vehicles

Salem, Aliasger K.; Behlke, Mark A.

doi:10.1002/9780470923733.ch6

RNA Interference 2010

DOI: 10.1002/9780470923733.ch6

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SiRNA Delivery Vehicles

Aliasger K. Salem

Mark A. Behlke

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2015

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References 184 publications

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“…It allows finely modulated target gene expression and hence regulates protein expression of the target tissue (3). This finding has great therapeutic potential for numerous diseases and injuries by enhancing regeneration capacity (4,5). Several small-RNA delivery methods have been applied recently to the treatment of genetic diseases and cancers (6,7), but thus far, few applications have been attempted that involve tissue engineering and regenerative medicine strategies to repair traumatic injury (3,8,9).…”

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confidence: 99%

Combination of small RNAs for skeletal muscle regeneration

et al. 2015

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Selectively controlling the expression of the target genes through RNA interference (RNAi) has significant therapeutic potential for injuries or diseases of tissues. We used this strategy to accelerate and enhance skeletal muscle regeneration for the treatment of muscular atrophy. In this study, we used myostatin small interfering (si)RNA (siGDF-8), a major inhibitory factor in the development and postnatal regeneration of skeletal muscle and muscle-specific microRNAs (miR-1 and -206) to further accelerate muscle regeneration. This combination of 3 small RNAs significantly improved the gene expression of myogenic regulatory factors in vitro, suggesting myogenic activation. Moreover, cell proliferation and myotube formation improved without compromising each other, which indicates the myogenic potential of this combination of small RNAs. The recovery of chemically injured tibialis anterior muscles in rats was significantly accelerated, both functionally and structurally. This novel combination of siRNA and miRNAs has promising therapeutic potential to improve in situ skeletal muscle regeneration.-Kim, N., Yoo, J. J., Atala, A., Lee, S. J. Combination of small RNAs for skeletal muscle regeneration. FASEB J. 30, 1198-1206 (2016). www.fasebj.org

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Combination of small RNAs for skeletal muscle regeneration

et al. 2015

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SiRNA Delivery Vehicles

Cited by 1 publication

References 184 publications

Combination of small RNAs for skeletal muscle regeneration

Combination of small RNAs for skeletal muscle regeneration

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