Sirolimus-induced lymphoedema

Motse, Kagiso; Mashabane, Mduduzi

doi:10.7196/samj.2016.v106i9.10636

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…Such modulation of these key pathways may deoptimize endothelial barrier repair during CHIKV infection leading to increased edema. Cell cycle arrest may also play a role in promoting edema (both for butyrate Figure 6E and high fiber diet Figure 4C), as edema is a well-known side-effect of rapamycin (173, 174), a drug that also induces G1 arrest.…”

Section: Discussionmentioning

confidence: 99%

Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate

et al. 2019

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Chikungunya virus (CHIKV) is a mosquito transmitted alphavirus associated with a robust systemic infection and an acute inflammatory rheumatic disease. A high fiber diet has been widely promoted for its ability to ameliorate inflammatory diseases. Fiber is fermented in the gut into short chain fatty acids such as acetate, propionate, and butyrate, which enter the circulation providing systemic anti-inflammatory activities. Herein we show that mice fed a high fiber diet show a clear exacerbation of CHIKV arthropathy, with increased edema and neutrophil infiltrates. RNA-Seq analyses illustrated that a high fiber diet, in this setting, promoted a range of pro-neutrophil responses including Th17/IL-17. Gene Set Enrichment Analyses demonstrated significant similarities with mouse models of inflammatory psoriasis and significant depression of macrophage resolution phase signatures in the CHIKV arthritic lesions from mice fed a high fiber diet. Supplementation of the drinking water with butyrate also increased edema after CHIKV infection. However, the mechanisms involved were different, with modulation of AP-1 and NF-κB responses identified, potentially implicating deoptimization of endothelial barrier repair. Thus, neither fiber nor short chain fatty acids provided benefits in this acute infectious disease setting, which is characterized by widespread viral cytopathic effects and a need for tissue repair.

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Section: Discussionmentioning

confidence: 99%

Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate

et al. 2019

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“…The patient was treated with lymphaticovenular anastomosis. Lastly, Motse et al reported a case of lymphedema associated with the use of immunosuppressant sirolimus after liver transplantation (13).…”

Section: Discussionmentioning

confidence: 99%

Role of Decongestive Therapy For Lymphedema In A Patient After Liver Transplantation: A Case Report

Leblebicier

Bakçepınar

Cihan

2022

Osmangazi̇ Journal of Medicine

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Lymphedema is defined as the abnormal accumulation of protein-rich fluid in the interstitial space as a result of deterioration in lymphatic system functions. In our case, we describe a patient that developed lymphedema symptoms in his right upper extremity following liver transplantation. After the lymphedema diagnosis, the patient underwent complex decongestive therapy, which included 30 sessions of manual lymphatic drainage (30 minutes a day) and 30 sessions of multilayer bandaging (five days a week). There was an improvement in both the shoulder joint range of motion and circumferences measurements of the hand and arm after treatment.Based on this case, we recommend manual lymph drainage as a preventative in the early period after organ transplants affecting the lymphatic system.

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Sirolimus-coated, poly(l-lactic acid)-modified polypropylene mesh with minimal intra-peritoneal adhesion formation in a rat model

Zhang

et al. 2018

Hernia

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Sirolimus-induced lymphoedema

Cited by 8 publications

References 11 publications

Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate

Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate

Role of Decongestive Therapy For Lymphedema In A Patient After Liver Transplantation: A Case Report

Sirolimus-coated, poly(l-lactic acid)-modified polypropylene mesh with minimal intra-peritoneal adhesion formation in a rat model

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